INT52678

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 3.94
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (VSX1) cellular_component (VSX1)
Anatomy Link Frequency
Hairs 2
striatum 1
epidermis 1
keratinocyte 1
tooth 1
VSX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn 2 99.48 Very High Very High Very High
cocaine 30 99.46 Very High Very High Very High
Opioid 15 99.00 Very High Very High Very High
Intracerebroventricular 12 97.88 Very High Very High Very High
Inflammation 14 97.68 Very High Very High Very High
Dynorphin 2 92.20 High High
antagonist 1 90.96 High High
electroacupuncture 2 86.56 High High
Analgesic 1 84.80 Quite High
spinal dorsal horn 1 83.88 Quite High
Disease Link Frequency Relevance Heat
Injury 6 99.24 Very High Very High Very High
Rheumatoid Arthritis 3 98.44 Very High Very High Very High
Systemic Lupus Erythematosus 3 98.16 Very High Very High Very High
INFLAMMATION 12 97.68 Very High Very High Very High
Rupture 8 96.68 Very High Very High Very High
Hypersensitivity 1 91.68 High High
Bullous Skin Disease 6 89.20 High High
Pressure And Volume Under Development 22 86.96 High High
Disease 62 84.88 Quite High
Necrosis 28 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that repeated, high dose cocaine administration induces an increased PPD but not PPE genomic response and that the expression of c-fos and zif/268 is dissociable from that of PPD.
Neg (not) Positive_regulation (increased) of PPD associated with cocaine
1) Confidence 0.42 Published 1994 Journal Synapse Section Abstract Doc Link 7825122 Disease Relevance 0 Pain Relevance 0.49
Image analysis of film autoradiograms demonstrated that 1 h after a single injection of cocaine, the expression of c-fos and zif/268, but not PPD or PPE in the dorsal striatum and cortex, was enhanced in a dose-dependent manner as compared to that in saline controls.
Positive_regulation (enhanced) of PPD in cortex associated with cocaine
2) Confidence 0.39 Published 1994 Journal Synapse Section Abstract Doc Link 7825122 Disease Relevance 0 Pain Relevance 0.55
Likewise, a mutation in the TCF8 gene, which causes PPCD type 3, has been found in one of 74 Chinese patients with FECD [121] and a mutation in the SLC4A11 gene have been detected in 4 individuals with late-onset FECD [109].


Positive_regulation (causes) of PPCD
3) Confidence 0.33 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.14 Pain Relevance 0
A single novel mutation in the TCF8 gene, which causes PPCD type 3, was only found in one of 74 Chinese patients with FECD [121].
Positive_regulation (causes) of PPCD
4) Confidence 0.33 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.53 Pain Relevance 0.04
In Turkey which is a country with a relatively high incidence of TB, in spite of a higher frequency of PPD positivity in AS patients compared to RA and SLE patients, TNF-blockers did not result in any TB with suitable prophylaxis.
Positive_regulation (frequency) of PPD associated with rheumatoid arthritis and systemic lupus erythematosus
5) Confidence 0.28 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18682953 Disease Relevance 1.02 Pain Relevance 0.18
PPD and vertical relative attachment levels (RAL-V) were measured to the nearest 0.5 mm using a straight periodontal probe (PCPUNC 15, Hu Friedy, Chicago, IL) at six sites per tooth.
Positive_regulation (measured) of PPD in tooth
6) Confidence 0.28 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.49 Pain Relevance 0
Image analysis of film autoradiograms demonstrated that 1 h after a single injection of cocaine, the expression of c-fos and zif/268, but not PPD or PPE in the dorsal striatum and cortex, was enhanced in a dose-dependent manner as compared to that in saline controls.
Positive_regulation (enhanced) of PPD in striatum associated with cocaine
7) Confidence 0.13 Published 1994 Journal Synapse Section Abstract Doc Link 7825122 Disease Relevance 0 Pain Relevance 0.55
In normal rats, 100 Hz, but not 2 Hz EAS triggered the nuclear export and membrane translocation of DREAM concomitantly with the upregulation of PPD mRNA in the dorsal horn.
Positive_regulation (upregulation) of PPD in dorsal horn associated with dorsal horn
8) Confidence 0.10 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18404375 Disease Relevance 0.26 Pain Relevance 0.55
The objective of this study was to determine whether transmission electron microscopy could be used to detect changes in the epidermis in induced PPD even before lesions were detectable by light microscopy.


Positive_regulation (induced) of PPD in epidermis
9) Confidence 0.05 Published 2008 Journal Clinics Section Body Doc Link PMC2664235 Disease Relevance 0.52 Pain Relevance 0
Two hours after PPD induction, granular degeneration of the keratin filaments and of the desmosomal plaques were observed in addition to the previously detected free desmosomes and vacuolization.
Positive_regulation (induction) of PPD in filaments
10) Confidence 0.05 Published 2008 Journal Clinics Section Body Doc Link PMC2664235 Disease Relevance 0.31 Pain Relevance 0
Hairs from the dorsum of four adult rats (Rattus norvegicus) were manually removed 72 hours before the experimental induction of PPD in order to avoid trauma artifacts.
Positive_regulation (induction) of PPD in Hairs associated with injury
11) Confidence 0.05 Published 2008 Journal Clinics Section Body Doc Link PMC2664235 Disease Relevance 0.49 Pain Relevance 0
Immediately after PPD induction, the skin showed keratinocyte cytoplasmatic vacuolization (Fig. 1a), and membrane ruptures were also visible near the sites of vacuolization.
Positive_regulation (induction) of PPD in keratinocyte associated with rupture
12) Confidence 0.05 Published 2008 Journal Clinics Section Body Doc Link PMC2664235 Disease Relevance 0.18 Pain Relevance 0
The sustained induction of striatal PPE and PPD mRNA indicates that pro-opioid gene transcription is not desensitized following 72 h of continuous adenylate cyclase activation.
Positive_regulation (induction) of PPD associated with opioid
13) Confidence 0.02 Published 1995 Journal Synapse Section Abstract Doc Link 7784955 Disease Relevance 0 Pain Relevance 0.44
To show that the data presented could be replicated in the same subject, we show runs taken when stimulating the opposite visual field (Figs. 6, 7).


Positive_regulation (stimulating) of visual field
14) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0
Continuous ICV infusion of 1, 9-dideoxyforskolin, a forskolin analog which does not activate adenylate cyclase, did not induce striatal PPE and PPD mRNA.
Neg (not) Positive_regulation (induce) of PPD associated with intracerebroventricular
15) Confidence 0.02 Published 1995 Journal Synapse Section Abstract Doc Link 7784955 Disease Relevance 0 Pain Relevance 0.40
Quantitative in situ hybridization histochemistry demonstrated that continuous activation of the adenylate cyclase/cAMP second messenger cascade results in a significant induction of striatal PPE and PPD mRNA at 6, 24, and 72 h.
Positive_regulation (induction) of PPD
16) Confidence 0.01 Published 1995 Journal Synapse Section Abstract Doc Link 7784955 Disease Relevance 0 Pain Relevance 0.44

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