INT52688

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 8.31
Pain Relevance 7.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
spinal cord 2
spinal nerve 1
spinal 1
foot 1
PGE2 1
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 15 100.00 Very High Very High Very High
Inflammation 39 99.84 Very High Very High Very High
Spinal nerve ligature 2 99.50 Very High Very High Very High
antagonist 3 99.42 Very High Very High Very High
Perioperative pain 15 99.16 Very High Very High Very High
cOX1 5 99.00 Very High Very High Very High
qutenza 9 98.96 Very High Very High Very High
Hyperalgesia 3 98.84 Very High Very High Very High
diclofenac 9 97.64 Very High Very High Very High
Spinal cord 8 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Infection 95 99.84 Very High Very High Very High
INFLAMMATION 33 99.84 Very High Very High Very High
Cirrhosis 8 99.84 Very High Very High Very High
Post Operative Pain 15 99.16 Very High Very High Very High
Hyperalgesia 3 98.84 Very High Very High Very High
Urological Neuroanatomy 3 97.24 Very High Very High Very High
Granuloma 4 97.12 Very High Very High Very High
Apoptosis 11 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lesion index (LI), pathohistology index, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) mRNA detected by RT-PCR were observed after 4 days.
Transcription (observed) of cyclooxygenase-2
1) Confidence 0.69 Published 2006 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 17200026 Disease Relevance 0.07 Pain Relevance 0
Lesion index (LI), pathohistology index, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) mRNA detected by RT-PCR were observed after 4 days.
Transcription (detected) of cyclooxygenase-2
2) Confidence 0.69 Published 2006 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 17200026 Disease Relevance 0.07 Pain Relevance 0
Injection of lipopolysaccharide into rat induced the expression of mRNA for cyclooxygenase-2 in the subcutaneous tissue of foot pad.
Transcription (expression) of cyclooxygenase-2 in foot
3) Confidence 0.60 Published 2001 Journal Inflamm. Res. Section Body Doc Link 11409492 Disease Relevance 0 Pain Relevance 0
Capsaicin treatment significantly modified gastric eNOS/iNOS/COX-2 mRNA expression in cirrhotic rats.
Transcription (expression) of COX-2 associated with cirrhosis and qutenza
4) Confidence 0.52 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18555214 Disease Relevance 0.77 Pain Relevance 0.76
PGE2 (1 microM) increased the transcription rate of PGHS-2 mRNA 9-fold at 2 h in serum-free cells and also induced PGHS-2 protein.
Transcription (transcription) of PGHS-2 mRNA
5) Confidence 0.43 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.25 Pain Relevance 0.15
The expression of mRNA for cyclooxygenase-2 was hardly detected in the intact cells but was clearly enhanced when the cells were incubated with the two NSAIDs.
Transcription (expression) of cyclooxygenase-2 associated with cinod
6) Confidence 0.42 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9851595 Disease Relevance 0.47 Pain Relevance 0.56
Levels of cyclooxygenase-2 (COX-2) mRNA, but not those of COX-1, were reported to be raised significantly after peripheral inflammation in the rat spinal cord.
Transcription (Levels) of cyclooxygenase-2 in spinal cord associated with inflammation and spinal cord
7) Confidence 0.37 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16918720 Disease Relevance 0.52 Pain Relevance 0.46
Levels of cyclooxygenase-2 (COX-2) mRNA, but not those of COX-1, were reported to be raised significantly after peripheral inflammation in the rat spinal cord.
Transcription (those) of cyclooxygenase-2 in spinal cord associated with inflammation and spinal cord
8) Confidence 0.37 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16918720 Disease Relevance 0.53 Pain Relevance 0.47
The effect of resveratrol, an aryl hydrocarbon receptor (AhR) antagonist, known to inhibit inducible cyclooxygenase-2 (COX2) and its transcription were examined in a model of hyperalgesia induced by carrageenan in the rat.
Transcription (transcription) of cyclooxygenase-2 associated with hyperalgesia, antagonist and cox2
9) Confidence 0.36 Published 2001 Journal Life Sci. Section Abstract Doc Link 11233998 Disease Relevance 0.52 Pain Relevance 0.43
The effect of [3,4-di(4-methoxyphenyl)-5-isoxazolyl] acetic acid (mofezolac), a potent and highly preferential inhibitor of cyclooxygenase-1, and N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulphonamide (NS-398), a selective inhibitor of cyclooxygenase-2, on DNA fragmentation and cyclooxygenase-2 mRNA expression was weak compared to the effect of indomethacin or sodium diclofenac.
Transcription (expression) of cyclooxygenase-2 associated with diclofenac
10) Confidence 0.33 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9851595 Disease Relevance 0.45 Pain Relevance 0.66
Different patterns of spinal cyclooxygenase-1 and cyclooxygenase-2 mRNA expression in inflammatory and postoperative pain.
Transcription (expression) of cyclooxygenase-2 in spinal associated with inflammation, perioperative pain and cox1
11) Confidence 0.29 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Title Doc Link 16918720 Disease Relevance 0.74 Pain Relevance 0.90
Four hours after NSAIDs, the following parameters were assessed: histomorphometric evaluation of gastric mucosal damage; gastric mucosal levels of myeloperoxidase (MPO), malondialdehyde (MDA), reduced glutathione as an index of non-proteic sulfhydryl compounds (GSH), and prostaglandin E2 (PGE2); mucosal cyclooxygenase-1 and -2 (COX-1, COX-2) mRNA expression by reverse transcription-polymerase chain reaction (RT-PCR).
Transcription (expression) of cyclooxygenase-1 and -2 in PGE2 associated with cinod and urological neuroanatomy
12) Confidence 0.29 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 16080005 Disease Relevance 0.30 Pain Relevance 0.65
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Transcription (levels) of cyclooxygenase-2 associated with necrosis, cancer and apoptosis
13) Confidence 0.22 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.75 Pain Relevance 0.72
Moreover, spinal nerve ligation animals showed enhanced transcription of the CREB/CRE-dependent gene COX-2 (cyclooxygenase 2), which also depends strictly on Ca(V)1.2 activation.
Transcription (transcription) of cyclooxygenase 2 in spinal nerve associated with spinal nerve ligature and cox2
14) Confidence 0.20 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20089916 Disease Relevance 0.69 Pain Relevance 1.06
Our results show that local administration of WIN 55,212-2, a CB(1)/CB(2) agonist, given daily or at time of implantation significantly decreased weight and neo-angiogenesis in granuloma tissue and inhibited nuclear factor-kappa B (NF-kappaB)/DNA binding that was associated with a reduced inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and vascular endothelial growth factor (VEGF) messenger RNA (mRNA) and protein expression.
Transcription (expression) of cyclooxygenase 2 associated with necrosis, cancer, agonist, cox2 and granuloma
15) Confidence 0.12 Published 2007 Journal J. Mol. Med. Section Abstract Doc Link 17447045 Disease Relevance 0.81 Pain Relevance 0.57
Infection alters transcription of a number of genes, including increased transcript levels of cyclooxygenase-2 [42],[43].
Transcription (transcription) of cyclooxygenase-2 associated with infection
16) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0.36 Pain Relevance 0.14

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