INT52689

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Context Info
Confidence 0.60
First Reported 1995
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 27
Total Number 32
Disease Relevance 12.76
Pain Relevance 10.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
brain 2
plasma 1
aorta 1
immune system 1
MC3T3-E1 1
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 62 100.00 Very High Very High Very High
cINOD 40 100.00 Very High Very High Very High
COX2 27 100.00 Very High Very High Very High
diclofenac 8 100.00 Very High Very High Very High
cOX1 3 100.00 Very High Very High Very High
Inflammatory mediators 1 100.00 Very High Very High Very High
Spinal cord 29 99.82 Very High Very High Very High
Pain 21 99.74 Very High Very High Very High
Lamotrigine 1 99.66 Very High Very High Very High
Antinociceptive 3 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 76 100.00 Very High Very High Very High
Ulcers 53 100.00 Very High Very High Very High
Fever 1 100.00 Very High Very High Very High
Cancer 7 99.92 Very High Very High Very High
Necrosis 3 99.68 Very High Very High Very High
Sepsis 2 99.54 Very High Very High Very High
Osteoporosis 4 99.08 Very High Very High Very High
Malignant Neoplastic Disease 1 98.76 Very High Very High Very High
Rheumatoid Arthritis 3 98.72 Very High Very High Very High
Dysmenorrhea 1 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bone cells contain both inducible and constitutive prostaglandin G/H synthase (PGHS-2 and PGHS-1) and these are differentially regulated.
Regulation (regulated) of PGHS-2
1) Confidence 0.60 Published 1997 Journal J. Bone Miner. Res. Section Abstract Doc Link 9258749 Disease Relevance 0.33 Pain Relevance 0.43
We examined regulation of messenger RNA levels for the inducible and constitutive prostaglandin G/H synthases, PGHS-2 and PGHS-1, in murine osteoblastic MC3T3-E1 cells, which express both PGHS-1 and PGHS-2, and in rat osteoblastic Py1a cells, which express only PGHS-2.
Spec (examined) Regulation (regulation) of PGHS-2 in MC3T3-E1 associated with osteoporosis
2) Confidence 0.56 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.27 Pain Relevance 0.05
Regulation of the inducible isoform, cyclooxygenase 2, is thought to play a key role in the brain's response to acute inflammatory stimuli.
Regulation (Regulation) of cyclooxygenase 2 in brain associated with cox2 and inflammatory stimuli
3) Confidence 0.55 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9130663 Disease Relevance 0.10 Pain Relevance 0.32
Tocolytic effect of the cyclooxygenase-2 inhibitor, meloxicam: studies on uterine contractions in the rat.
Regulation (effect) of cyclooxygenase-2 in uterine associated with dismenorea
4) Confidence 0.45 Published 1998 Journal J. Pharm. Pharmacol. Section Title Doc Link 9680081 Disease Relevance 0.19 Pain Relevance 0.14
AIM: To determine the effect of indometacin, celecoxib, a cyclooxygenase-2-specific inhibitor, and nabumetone, a pro-drug, on ulcer healing rates in the rat.
Spec (determine) Regulation (effect) of cyclooxygenase-2-specific
5) Confidence 0.45 Published 2001 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 11736732 Disease Relevance 0 Pain Relevance 0
The aim of this study was to investigate the effect of a selective cyclooxygenase-2 inhibitor (meloxicam) on bone healing in calvarial defects in rats.
Spec (investigate) Regulation (effect) of cyclooxygenase-2
6) Confidence 0.44 Published 2005 Journal Brazilian oral research Section Abstract Doc Link 16491262 Disease Relevance 0.10 Pain Relevance 0.18
Effects of a cyclooxygenase-2 inhibitor (rofecoxib) on bone healing.
Regulation (Effects) of cyclooxygenase-2
7) Confidence 0.40 Published 2006 Journal Am J. Orthop. Section Title Doc Link 16584081 Disease Relevance 0.09 Pain Relevance 0.09
INTRODUCTION: The purpose of this study was to compare the effects of a conventional nonsteroidal anti-inflammatory drug, diclofenac (Voltaren [Novartis, Barcelona, Spain]), and a specific cyclooxygenase-2 (COX-2) inhibitor, rofecoxib (Vioxx [MSD, Madrid, Spain]), on the inhibition of dental movement induced with a coil-spring orthodontic apparatus in rats.
Regulation (effects) of cyclooxygenase-2 associated with inflammation, cinod and diclofenac
8) Confidence 0.35 Published 2006 Journal Am J Orthod Dentofacial Orthop Section Abstract Doc Link 16527637 Disease Relevance 0.10 Pain Relevance 0.15
This study examined the effects of the cyclooxygenase-2 (COX-2) inhibitor, meloxicam, on responses of spinal dorsal horn neurones to synaptic inputs in vivo.
Spec (examined) Regulation (effects) of cyclooxygenase-2 in dorsal horn associated with spinal dorsal horn
9) Confidence 0.31 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11356304 Disease Relevance 0 Pain Relevance 0.12
Neonatal exposure to lipopolysaccharide (LPS), an established model of immune system activation, has been shown to affect febrile and cyclooxygenase-2 (COX-2) responses to a similar exposure in adulthood.
Regulation (affect) of cyclooxygenase-2 in immune system associated with fever
10) Confidence 0.31 Published 2005 Journal Pain Section Abstract Doc Link 16297551 Disease Relevance 0.74 Pain Relevance 0.49
Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats.
Regulation (effects) of cyclooxygenase-2 in plasma associated with inflammation and cox1
11) Confidence 0.31 Published 2001 Journal Inflammation Section Title Doc Link 11321358 Disease Relevance 0.46 Pain Relevance 0.29
Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease.
Regulation (regulation) of cyclooxygenase-2 in brain associated with cox2 and disease
12) Confidence 0.29 Published 1997 Journal Exp. Neurol. Section Title Doc Link 9168834 Disease Relevance 0.54 Pain Relevance 0.11
Effects of non-steroidal anti-inflammatory drugs on prostaglandin E2 production by cyclooxygenase-2 from endogenous and exogenous arachidonic acid in rat peritoneal macrophages stimulated with lipopolysaccharide.
Regulation (Effects) of cyclooxygenase-2 in peritoneal macrophages associated with inflammation, cinod and cox1
13) Confidence 0.28 Published 1996 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 9014225 Disease Relevance 0.19 Pain Relevance 0.65
Since variants in the PTGS2 gene may modify the expression or function of its encoded enzyme to modulate the inflammatory response in the biliary tract, we examined the associations of eight PTGS2 polymorphisms (-645C-->T; Ex3 -8G-->C; IVS5 -275T-->G; IVS7 +111T-->C; Ex10 +127T-->C; Ex10 +686 --->ATTAT-->TTATA; Ex10 +837T-->C; Ex10 -90C-->T) with biliary tract cancer and stones in a population-based case-control study conducted in Shanghai, China.
Regulation (function) of PTGS2 in biliary tract associated with inflammatory response and biliary cancer
14) Confidence 0.28 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16361272 Disease Relevance 0.84 Pain Relevance 0.50
In contrast, the anticonvulsant lamotrigine (30 mg/kg), the cyclooxygenase-2 inhibitor carprofen (15 mg/kg) and the benzodiazepine diazepam (3 mg/kg) were ineffective.
Regulation (ineffective) of cyclooxygenase-2 associated with lamotrigine and anticonvulsant
15) Confidence 0.27 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15033380 Disease Relevance 0.23 Pain Relevance 1.15
We have examined the effects of the selective cyclooxygenase-2 inhibitor nimesulide and the non-selective cyclooxygenase inhibitor indomethacin on vascular responsiveness of endothelium-denuded rat aorta.
Spec (examined) Regulation (effects) of cyclooxygenase-2 in aorta
16) Confidence 0.23 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9718267 Disease Relevance 0 Pain Relevance 0.31
Effects of the selective cyclooxygenase-2 inhibitor nimesulide on vascular contractions in endothelium-denuded rat aorta.
Regulation (Effects) of cyclooxygenase-2 in endothelium associated with cox2
17) Confidence 0.23 Published 1998 Journal Eur. J. Pharmacol. Section Title Doc Link 9718267 Disease Relevance 0 Pain Relevance 0.38
The effects of cyclooxygenase 2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis-induced monoarticular arthritis in the rat.
Regulation (effects) of cyclooxygenase 2 in cartilage associated with mycobacterial infection, cox2 and arthritis
18) Confidence 0.22 Published 1998 Journal Inflammation Section Title Doc Link 9793797 Disease Relevance 0.93 Pain Relevance 0.43
Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing.
Regulation (effects) of cyclooxygenase-2
19) Confidence 0.21 Published 2007 Journal J Bone Joint Surg Am Section Title Doc Link 17332098 Disease Relevance 0.43 Pain Relevance 0.39
Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat.
Regulation (effect) of cyclooxygenase-2 associated with nociception, cox2 and diclofenac
20) Confidence 0.18 Published 1998 Journal Neurosci. Lett. Section Title Doc Link 9665655 Disease Relevance 0.51 Pain Relevance 0.80

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