INT52690

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Context Info
Confidence 0.68
First Reported 1995
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 65
Total Number 68
Disease Relevance 39.51
Pain Relevance 30.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
spinal cord 6
brain 3
MC3T3-E1 3
PGE2 2
dorsal 2
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 177 100.00 Very High Very High Very High
Pain 93 100.00 Very High Very High Very High
COX2 86 100.00 Very High Very High Very High
Spinal cord 82 100.00 Very High Very High Very High
Dorsal horn 30 100.00 Very High Very High Very High
acular 27 100.00 Very High Very High Very High
Analgesic 15 100.00 Very High Very High Very High
cOX1 13 100.00 Very High Very High Very High
Thalamus 8 100.00 Very High Very High Very High
Locus ceruleus 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 216 100.00 Very High Very High Very High
Adhesions 3 100.00 Very High Very High Very High
Nervous System Injury 72 99.96 Very High Very High Very High
Sprains And Strains 104 99.92 Very High Very High Very High
Cancer 29 99.92 Very High Very High Very High
Diabetes Mellitus 98 99.82 Very High Very High Very High
Death 115 99.78 Very High Very High Very High
Necrosis 16 99.68 Very High Very High Very High
Neuropathic Pain 142 99.64 Very High Very High Very High
Urological Neuroanatomy 5 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, intrathecal injection of indomethacin had no effect on established allodynia two weeks after nerve injury.Collectively, our results suggest that cyclooxygenase-2 is preferentially up-regulated in the dorsal spinal cord and thalamus in response to nerve injury in rats.
Positive_regulation (up-regulated) of cyclooxygenase-2 in dorsal associated with nervous system injury, allodynia, thalamus, spinal cord and intrathecal
1) Confidence 0.68 Published 2000 Journal Neuroscience Section Abstract Doc Link 10842019 Disease Relevance 0.86 Pain Relevance 0.94
We have monitored levels of cyclooxygenase messenger RNA and prostaglandins in lumbar spinal cord in parallel with these behavioural responses (oedema, hyperalgesia and allodynia) and identified a marked increase in cyclooxygenase-2 messenger RNA (3-fold), maximal at 2-4 h after Freund's complete adjuvant, followed by a significant increase in 6-keto prostaglandin F1alpha and prostaglandin E2 which is maximal by 8 h.
Positive_regulation (increase) of cyclooxygenase-2 messenger RNA in spinal cord associated with pressure and volume under development, hyperalgesia, allodynia and spinal cord
2) Confidence 0.67 Published 1997 Journal Neuroscience Section Abstract Doc Link 9153662 Disease Relevance 1.64 Pain Relevance 1.26
The marked increase in cyclooxygenase-2 messenger RNA in the lumbar spinal cord following intraplantar Freund's complete adjuvant suggests that the cyclooxygenase enzyme and its product may have a role in the adaptive response that occurs in the lumbar spinal cord during a peripheral inflammatory reaction.
Positive_regulation (increase) of cyclooxygenase-2 messenger RNA in spinal cord associated with inflammation and spinal cord
3) Confidence 0.67 Published 1997 Journal Neuroscience Section Abstract Doc Link 9153662 Disease Relevance 1.52 Pain Relevance 1.36
The long-term exposure of rat cultured dorsal root ganglion cells to bradykinin induced the release of prostaglandin E2 by the activation of cyclooxygenase-2.
Positive_regulation (activation) of cyclooxygenase-2 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, cox2 and bradykinin
4) Confidence 0.67 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16580130 Disease Relevance 0.44 Pain Relevance 0.87
PGE2 (1 microM) increased the transcription rate of PGHS-2 mRNA 9-fold at 2 h in serum-free cells and also induced PGHS-2 protein.
Positive_regulation (induced) of PGHS-2 protein
5) Confidence 0.64 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.30 Pain Relevance 0.21
The prolonged treatment of myometrial cells with LPS or SFTPA1 upregulated PTGS2 (COX2) protein levels.
Positive_regulation (upregulated) of PTGS2 associated with cox2
6) Confidence 0.56 Published 2007 Journal Biol. Reprod. Section Abstract Doc Link 17202387 Disease Relevance 0.33 Pain Relevance 0.15
The endothelial cells but not the paraventricular hypothalamic cells displayed a concomitant induction of cyclooxygenase-2 and expressed interleukin-1 type 1 receptors, which indicates that the induction is due to peripherally released cytokines.
Positive_regulation (induction) of cyclooxygenase-2 in endothelial cells associated with cytokine
7) Confidence 0.52 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 12353217 Disease Relevance 0.61 Pain Relevance 0.27
In BOHF treated animals, cyclooxygenase-2 and iNOS inductions were inhibited in ischemic hemispheres at both the mRNA and protein levels.
Positive_regulation (inductions) of cyclooxygenase-2
8) Confidence 0.51 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880613 Disease Relevance 0.48 Pain Relevance 0.19
Cyclooxygenase-2-immunoreactivity was induced in the blood vessels of the injected hemisphere in perivascular microglial and endothelial cells 24 h after injection.
Positive_regulation (induced) of Cyclooxygenase-2 in blood vessels
9) Confidence 0.50 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10886331 Disease Relevance 0.65 Pain Relevance 0.25
These results suggest that the inflammatory response associated with cyclooxygenase-2 induction is involved in the opposite change in ileal tryptophan hydroxylase and monoamine oxidase activities in the delayed phase after single administration of cisplatin to rats.
Positive_regulation (induction) of cyclooxygenase-2 associated with inflammatory response and monoamine
10) Confidence 0.50 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18534574 Disease Relevance 0.27 Pain Relevance 0.53
The inflammatory response was associated with the induction of cyclooxygenase-2, but not cyclooxygenase-1, in the ileal mucosa at 72 h after the cisplatin administration.
Positive_regulation (induction) of cyclooxygenase-2 associated with inflammatory response
11) Confidence 0.50 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18534574 Disease Relevance 0.36 Pain Relevance 0.36
Using western blot analysis, we found that the cyclooxygenase-2 protein levels in the dorsal spinal cord and thalamus (but not in the ventral spinal cord, cingulate cortex and locus coeruleus) increased significantly one day after nerve ligation, compared with those in the sham animals.
Positive_regulation (increased) of cyclooxygenase-2 in thalamus associated with locus ceruleus, thalamus and spinal cord
12) Confidence 0.49 Published 2000 Journal Neuroscience Section Abstract Doc Link 10842019 Disease Relevance 0.82 Pain Relevance 0.71
Cyclooxygenase-2, the inducible isoform of cyclooxygenase, is highly expressed in microglial cells activated by bacterial lipopolysaccharide and is a major regulatory factor in the synthesis of prostanoids, such as prostaglandins, prostacyclin and thromboxanes.
Positive_regulation (inducible) of Cyclooxygenase-2 in microglial cells
13) Confidence 0.48 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182946 Disease Relevance 0.23 Pain Relevance 0.11
Both forskolin, a protein kinase A activator, and phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, have previously been shown to induce PGHS-2 mRNA in MC3T3-E1 cells, but in the present study only PMA induced PGHS-2 expression in Py1a cells.
Positive_regulation (induce) of PGHS-2 mRNA in MC3T3-E1 associated with kinase c
14) Confidence 0.46 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.30 Pain Relevance 0.32
Prostaglandins E2, F2 alpha, and D2 induced PGHS-2 mRNA in both cell lines under serum-free conditions and stimulated small increases in PGHS-1 mRNA levels in MC3T3-E1 cells.
Positive_regulation (induced) of PGHS-2 mRNA in MC3T3-E1
15) Confidence 0.46 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.27 Pain Relevance 0.11
The induction of PGHS-2 mRNA in Py1a cells by PGs was inhibited by chelerythrine, a PKC inhibitor, and blocked by 24 h of pretreatment with PMA.
Positive_regulation (induction) of PGHS-2 mRNA associated with kinase c
16) Confidence 0.46 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.30 Pain Relevance 0.33
The 2 h serum stimulation of PGHS-2 mRNA in MC3T3-E1 cells was inhibited 40-50% by three structurally unrelated nonsteroidal anti-inflammatory drugs (NSAIDs), suggesting that endogenous PGs also amplify PG production through induction of PGHS-2.
Positive_regulation (stimulation) of PGHS-2 mRNA in MC3T3-E1 associated with inflammation and cinod
17) Confidence 0.46 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.30 Pain Relevance 0.36
Bone cells contain both inducible and constitutive prostaglandin G/H synthase (PGHS-2 and PGHS-1) and these are differentially regulated.
Positive_regulation (inducible) of PGHS-2
18) Confidence 0.45 Published 1997 Journal J. Bone Miner. Res. Section Abstract Doc Link 9258749 Disease Relevance 0.32 Pain Relevance 0.39
Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages.
Positive_regulation (induces) of cyclooxygenase 2 in brain associated with cox2
19) Confidence 0.45 Published 1997 Journal J. Comp. Neurol. Section Title Doc Link 9130663 Disease Relevance 0.08 Pain Relevance 0.31
In this paper, we report that intravenous lipopolysaccharide (LPS or endotoxin) induces cyclooxygenase 2-like immunoreactivity in cells closely associated with brain blood vessels and in cells in the meninges.
Positive_regulation (induces) of cyclooxygenase 2 in brain blood vessels associated with cox2
20) Confidence 0.45 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9130663 Disease Relevance 0.10 Pain Relevance 0.31

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