INT52691

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1995
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.00
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
foot 2
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 6 100.00 Very High Very High Very High
antagonist 1 99.62 Very High Very High Very High
Hyperalgesia 3 98.84 Very High Very High Very High
cINOD 9 98.24 Very High Very High Very High
Spinal cord 4 96.88 Very High Very High Very High
diclofenac 4 93.52 High High
Pain 6 82.80 Quite High
Kinase C 3 81.04 Quite High
Inflammation 10 80.40 Quite High
adenocard 1 78.96 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 3 98.84 Very High Very High Very High
Cancer 1 95.92 Very High Very High Very High
Necrosis 1 95.68 Very High Very High Very High
Apoptosis 6 94.72 High High
Osteoporosis 3 90.76 High High
Pressure And Volume Under Development 2 90.16 High High
Frailty 6 87.80 High High
Injury 6 85.36 High High
Pain 5 82.80 Quite High
Colon Cancer 1 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injection of lipopolysaccharide into rat induced the expression of mRNA for cyclooxygenase-2 in the subcutaneous tissue of foot pad.
Positive_regulation (induced) of Transcription (expression) of cyclooxygenase-2 in foot
1) Confidence 0.44 Published 2001 Journal Inflamm. Res. Section Body Doc Link 11409492 Disease Relevance 0 Pain Relevance 0
PGE2 (1 microM) increased the transcription rate of PGHS-2 mRNA 9-fold at 2 h in serum-free cells and also induced PGHS-2 protein.
Positive_regulation (increased) of Transcription (transcription) of PGHS-2 mRNA
2) Confidence 0.37 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.25 Pain Relevance 0.15
The expression of mRNA for cyclooxygenase-2 was hardly detected in the intact cells but was clearly enhanced when the cells were incubated with the two NSAIDs.
Positive_regulation (enhanced) of Transcription (expression) of cyclooxygenase-2 associated with cinod
3) Confidence 0.31 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9851595 Disease Relevance 0.47 Pain Relevance 0.60
The effect of resveratrol, an aryl hydrocarbon receptor (AhR) antagonist, known to inhibit inducible cyclooxygenase-2 (COX2) and its transcription were examined in a model of hyperalgesia induced by carrageenan in the rat.
Positive_regulation (inducible) of Transcription (transcription) of cyclooxygenase-2 associated with hyperalgesia, antagonist and cox2
4) Confidence 0.25 Published 2001 Journal Life Sci. Section Abstract Doc Link 11233998 Disease Relevance 0.52 Pain Relevance 0.43
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Positive_regulation (increase) of Transcription (levels) of cyclooxygenase-2 associated with necrosis, cancer and apoptosis
5) Confidence 0.16 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.76 Pain Relevance 0.72

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox