INT52694

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.72
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
lung 2
MC3T3-E1 2
PGE2 2
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 14 100.00 Very High Very High Very High
Kinase C 9 100.00 Very High Very High Very High
COX2 7 100.00 Very High Very High Very High
antagonist 1 99.78 Very High Very High Very High
cINOD 21 98.40 Very High Very High Very High
Hyperalgesia 3 97.68 Very High Very High Very High
Analgesic 1 97.40 Very High Very High Very High
cytokine 1 87.76 High High
headache 1 77.20 Quite High
aspirin 5 75.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 22 100.00 Very High Very High Very High
Diabetes Mellitus 7 100.00 Very High Very High Very High
Adhesions 2 100.00 Very High Very High Very High
Hyperalgesia 3 97.68 Very High Very High Very High
Ganglion Cysts 2 95.08 Very High Very High Very High
Injury 2 92.64 High High
Female Infertility 1 91.44 High High
Pleurisy 2 91.32 High High
Pressure And Volume Under Development 2 87.84 High High
Middle Cerebral Artery Infarction 2 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In BOHF treated animals, cyclooxygenase-2 and iNOS inductions were inhibited in ischemic hemispheres at both the mRNA and protein levels.
Negative_regulation (inhibited) of Positive_regulation (inductions) of cyclooxygenase-2
1) Confidence 0.43 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880613 Disease Relevance 0.48 Pain Relevance 0.19
The 2 h serum stimulation of PGHS-2 mRNA in MC3T3-E1 cells was inhibited 40-50% by three structurally unrelated nonsteroidal anti-inflammatory drugs (NSAIDs), suggesting that endogenous PGs also amplify PG production through induction of PGHS-2.
Negative_regulation (inhibited) of Positive_regulation (stimulation) of PGHS-2 mRNA in MC3T3-E1 associated with inflammation and cinod
2) Confidence 0.39 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.30 Pain Relevance 0.36
The induction of PGHS-2 mRNA in Py1a cells by PGs was inhibited by chelerythrine, a PKC inhibitor, and blocked by 24 h of pretreatment with PMA.
Negative_regulation (blocked) of Positive_regulation (induction) of PGHS-2 mRNA associated with kinase c
3) Confidence 0.39 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.30 Pain Relevance 0.35
The induction of PGHS-2 mRNA in Py1a cells by PGs was inhibited by chelerythrine, a PKC inhibitor, and blocked by 24 h of pretreatment with PMA.
Negative_regulation (inhibited) of Positive_regulation (induction) of PGHS-2 mRNA associated with kinase c
4) Confidence 0.39 Published 1995 Journal J. Bone Miner. Res. Section Abstract Doc Link 7785462 Disease Relevance 0.30 Pain Relevance 0.34
A 30-min. pre-treatment with K5NOSepiLMW (0.1, 0.5 and 1 mg/kg b.wt., given intrapleurally) attenuated the recruitment of leucocytes in the lung tissue and the pleural exudate, inhibited the induction of inducible nitric oxide synthase and cyclooxygenase-2 (COX-2), thereby abating the generation of nitric oxide and pro-inflammatory prostaglandins such as PgE(2) and PGF(1alpha), reduced the inflammation-induced nitroxidative lung tissue injury, as shown by tissue thiobarbituric acid-reactive substances and nitrotyrosine, and blunted the local generation of cytokines such as interleukin-1beta and tumour necrosis factor-alpha.
Negative_regulation (inhibited) of Positive_regulation (induction) of cyclooxygenase-2 in lung associated with necrosis, inflammation, cancer, injury and cytokine
5) Confidence 0.25 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 20141620 Disease Relevance 1.09 Pain Relevance 0.59
The effect of resveratrol, an aryl hydrocarbon receptor (AhR) antagonist, known to inhibit inducible cyclooxygenase-2 (COX2) and its transcription were examined in a model of hyperalgesia induced by carrageenan in the rat.
Negative_regulation (inhibit) of Positive_regulation (inducible) of cyclooxygenase-2 associated with hyperalgesia, antagonist and cox2
6) Confidence 0.22 Published 2001 Journal Life Sci. Section Abstract Doc Link 11233998 Disease Relevance 0.51 Pain Relevance 0.43
Sulfasalazine (also as a representative of the salicylates) inhibited the diabetes-induced upregulation of several inflammatory gene products, which are regulated by NF-kappaB, including vascular cell adhesion molecule, intracellular adhesion molecule-1, inducible nitric oxide synthase, and cyclooxygenase-2 in whole-retinal lysate.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of cyclooxygenase-2 associated with inflammation, diabetes mellitus and adhesions
7) Confidence 0.16 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.22 Pain Relevance 0.16
Non-steroidal anti-inflammatory drugs (NSAIDs), widely used due to their analgesic and anti-inflammatory properties, consistently inhibit ovulation in all mammalian species investigated so far, likely due to the inhibition of cyclooxygenase 2 (COX-2), the inducible isoform of COX, that is the rate-limiting enzyme in prostaglandin (PG) synthesis.
Negative_regulation (inhibition) of Positive_regulation (inducible) of cyclooxygenase 2 associated with inflammation, analgesic, cinod and cox2
8) Confidence 0.15 Published 2006 Journal Histol. Histopathol. Section Abstract Doc Link 16493584 Disease Relevance 0.44 Pain Relevance 0.63
These compounds inhibit the induction of cyclooxygenase-2 (COX-2), thus inhibiting PGE2 production.
Negative_regulation (inhibit) of Positive_regulation (induction) of cyclooxygenase-2 in PGE2
9) Confidence 0.12 Published 2008 Journal Inflamm Allergy Drug Targets Section Abstract Doc Link 18782027 Disease Relevance 0.07 Pain Relevance 0.07

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