INT52695

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1993
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 8.72
Pain Relevance 5.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
macrophage 1
RAW 264 1
bone marrow 1
brain 1
forebrain 1
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 36 100.00 Very High Very High Very High
COX2 27 100.00 Very High Very High Very High
aspirin 5 100.00 Very High Very High Very High
Nicotine 4 100.00 Very High Very High Very High
Limbic system 1 99.08 Very High Very High Very High
Neuropathic pain 5 99.04 Very High Very High Very High
cytokine 5 98.90 Very High Very High Very High
Inflammation 83 98.78 Very High Very High Very High
ischemia 7 97.68 Very High Very High Very High
Pain 5 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 11 99.92 Very High Very High Very High
Osteoporosis 3 99.84 Very High Very High Very High
INFLAMMATION 105 99.74 Very High Very High Very High
Chronic Periodontitis 15 99.20 Very High Very High Very High
Adhesions 4 99.10 Very High Very High Very High
Neuropathic Pain 5 99.04 Very High Very High Very High
Esophageal Cancer 3 99.00 Very High Very High Very High
Targeted Disruption 21 98.96 Very High Very High Very High
Cerebrovascular Disease 1 98.96 Very High Very High Very High
Toxicity 1 98.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only a few experimental studies have demonstrated the effectiveness of some cyclooxygenase-2 (COX-2) inhibitors for neuropathic pain in diabetic animals.
Regulation (effectiveness) of cyclooxygenase-2 associated with diabetes mellitus and neuropathic pain
1) Confidence 0.42 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19498273 Disease Relevance 0.65 Pain Relevance 0.53
In this study, we examined a dose-dependent effect of a cyclooxygenase-2 (COX-2) inhibitor, celecoxib against transgenic adenocarcinoma of the mouse prostate.
Spec (examined) Regulation (effect) of cyclooxygenase-2 associated with adenocarcinoma and targeted disruption
2) Confidence 0.28 Published 2006 Journal Prostate Section Abstract Doc Link 16175586 Disease Relevance 0.39 Pain Relevance 0.24
Although the first of these isozymes, PGH synthase-1 (PGHS-1), has long been thought to be the primary and sole site of action of nonsteroidal antiinflammatory drugs (NSAIDs), it is now known that the second isozyme, PGH synthase-2 (PGHS-2), is also sensitive to NSAIDs.
Regulation (sensitive) of PGH synthase-2 associated with inflammation and cinod
3) Confidence 0.26 Published 1993 Journal Am. J. Med. Section Abstract Doc Link 8357002 Disease Relevance 0.17 Pain Relevance 0.28
Although the first of these isozymes, PGH synthase-1 (PGHS-1), has long been thought to be the primary and sole site of action of nonsteroidal antiinflammatory drugs (NSAIDs), it is now known that the second isozyme, PGH synthase-2 (PGHS-2), is also sensitive to NSAIDs.
Regulation (sensitive) of PGHS-2 associated with inflammation and cinod
4) Confidence 0.26 Published 1993 Journal Am. J. Med. Section Abstract Doc Link 8357002 Disease Relevance 0.17 Pain Relevance 0.28
Because the mouse is a useful model for age-related decline in nAChR expression in the basal forebrain and limbic system, we used immunohistochemistry to examine the influence of long-term (12-month) oral administration of nicotine and/or the cyclooxygenase-2 (COX-2) preferring non-steroidal anti-inflammatory drug (NSAID) NS398 on nAChR alpha4, alpha5, alpha7, and beta4 expression in the C57BL/6 mouse.
Regulation (influence) of cyclooxygenase-2 in forebrain associated with inflammation, nicotine, cinod and limbic system
5) Confidence 0.26 Published 2005 Journal J. Neurobiol. Section Abstract Doc Link 15551346 Disease Relevance 0.36 Pain Relevance 0.47
However, recent studies raise concern about potential cardiovascular toxicity associated with the use of NSAIDs that specifically target the enzyme cyclooxygenase 2.
Regulation (target) of cyclooxygenase 2 associated with toxicity, cinod and cox2
6) Confidence 0.23 Published 2006 Journal Nat. Rev. Cancer Section Abstract Doc Link 16491072 Disease Relevance 0.43 Pain Relevance 0.45
Roles of cyclooxygenase-2 and prostacyclin/IP receptors in mucosal defense against ischemia/reperfusion injury in mouse stomach.
Regulation (Roles) of cyclooxygenase-2 in stomach associated with reperfusion injury, ischemia and cox2
7) Confidence 0.21 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16236816 Disease Relevance 0.47 Pain Relevance 0.38
Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain.
Regulation (dependent) of cyclooxygenase 2 in brain associated with pressure and volume under development and cox2
8) Confidence 0.20 Published 2004 Journal Radiat. Res. Section Title Doc Link 14731075 Disease Relevance 0.76 Pain Relevance 0.49
The mean change in expression level of Cox1 (Ptgs1) and Cox2 (Ptgs2), and a selection of Cox2-dependent genes involved in inflammation (intracellular adhesion molecule 1, Icam1; Transforming growth factor b1,Tgfb1), gastric function (Gastrin, Gast), barrier function (Aquaporin 5, Aqp5; Tight junction protein 1, Tjp1) and proliferation/carcinogenesis (Ornithine decarboxylase, Odc1) was determined for individual mice at all time points by real-time PCR (Additional File 1, Table S4).
Spec (determined) Regulation (change) of Ptgs2 associated with inflammation and adhesions
9) Confidence 0.20 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.45 Pain Relevance 0.10
Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly.
Regulation (Effect) of cyclooxygenase 2 associated with cox2 and myocardial infarction
10) Confidence 0.18 Published 2003 Journal Arch. Intern. Med. Section Title Doc Link 12588209 Disease Relevance 0.19 Pain Relevance 0.30
In a previous study, we reported a new gamma-hydroxybutenolide derivative, 4-benzo[b]thiophen-2-yl-3-bromo-5-hydroxy-5H-furan-2-one (BTH), as inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) expression in lypopolysaccharide (LPS) stimulated RAW 264.7 and TPH-1 cells, without affecting cyclooxygenase-2 (COX-2).
Neg (without) Regulation (affecting) of cyclooxygenase-2 in RAW 264
11) Confidence 0.15 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19686718 Disease Relevance 0.23 Pain Relevance 0.19
However, defeminization can occur by an increased level of estradiol [6,33,34], and perhaps masculinization by affecting cyclooxygenase-2 (COX-2) regulation to increase prostaglandin E2 (PGE2) [35].
Regulation (regulation) of cyclooxygenase-2
12) Confidence 0.15 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.09 Pain Relevance 0
The cyclooxygenase-2 (COX-2) gene plays a role in a wide variety of normal physiologic pathways and is a major target of pharmacologic intervention in a large number of pathophysiologic contexts, including pain, fever, inflammation, and cancer.
Regulation (target) of cyclooxygenase-2 associated with pain, inflammation, cancer and fever
13) Confidence 0.15 Published 2003 Journal Mol Imaging Biol Section Abstract Doc Link 14499140 Disease Relevance 0.38 Pain Relevance 0.21
New anti-inflammatory synthetic biflavonoid with C-C (6-6") linkage: differential effects on cyclooxygenase-2 and inducible nitric oxide synthase.
Regulation (effects) of cyclooxygenase-2 associated with inflammation and cox2
14) Confidence 0.14 Published 2009 Journal Arch. Pharm. Res. Section Title Doc Link 20091265 Disease Relevance 0.55 Pain Relevance 0.46
-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) is anti-inflammatory [10]; decreases cytokines, adhesion molecules, and reactive oxygen species; and regulates cyclooxygenase-2 (COX-2) activity [11].
Regulation (regulates) of cyclooxygenase-2 associated with inflammation, adhesions and cytokine
15) Confidence 0.13 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834569 Disease Relevance 0.70 Pain Relevance 0.22
The present study was designed to determine whether: (a) chronic administration of dietary celecoxib (Celebrex), a potent nonsteroidal anti-inflammatory drug, which targets the cyclooxygenase-2 (COX-2) enzyme, negatively impacts host immunity; and (b) celecoxib can be coupled with a poxvirus-based vaccine to impact tumor burden in a murine tumor model of spontaneous adenomatous polyposis coli.
Regulation (targets) of cyclooxygenase-2 associated with inflammation, cancer, familial adenomatous polyposis and cinod
16) Confidence 0.13 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15150127 Disease Relevance 0.52 Pain Relevance 0.10
SPEE significantly decreased nitrite content and induced nitric oxide synthase (iNOS) in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells, while it could not modulate cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 levels in the stimulated phages.
Neg (not) Regulation (modulate) of cyclooxygenase-2 in macrophage
17) Confidence 0.11 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19715750 Disease Relevance 0 Pain Relevance 0
The anti-inflammatory actions of the extract and the fraction may be due to an inhibitory effect on histamine and cyclooxygenase II, but not on cyclooxygenase I, because the extract and it's fraction present both anti-inflammatory and anti-ulcerogenic effects.
Neg (not) Regulation (effect) of cyclooxygenase II associated with inflammation
18) Confidence 0.10 Published 1998 Journal J Ethnopharmacol Section Abstract Doc Link 9705013 Disease Relevance 0.57 Pain Relevance 0.25
Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
Regulation (Effects) of Cyclooxygenase-2 in bone marrow associated with cox2
19) Confidence 0.08 Published 2006 Journal Arch. Pharm. Res. Section Title Doc Link 17121182 Disease Relevance 0 Pain Relevance 0.11
Effect of chronic intake of NSAIDs and cyclooxygenase 2-selective inhibitors on esophageal cancer incidence.
Regulation (Effect) of cyclooxygenase 2 associated with aspirin, cinod, cox2 and esophageal cancer
20) Confidence 0.07 Published 2004 Journal Clin. Gastroenterol. Hepatol. Section Title Doc Link 15476151 Disease Relevance 0.19 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox