INT52696

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 48
Total Number 50
Disease Relevance 27.65
Pain Relevance 14.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
macrophages 7
brain 3
RAW 264 3
platelet 2
fibroblasts 2
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 400 100.00 Very High Very High Very High
cINOD 90 100.00 Very High Very High Very High
COX2 71 100.00 Very High Very High Very High
Pain 32 100.00 Very High Very High Very High
cva 8 99.92 Very High Very High Very High
qutenza 22 99.84 Very High Very High Very High
cytokine 117 99.32 Very High Very High Very High
Inflammatory response 54 99.28 Very High Very High Very High
Analgesic 22 99.20 Very High Very High Very High
carpal tunnel syndrome 10 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 523 100.00 Very High Very High Very High
Death 115 99.92 Very High Very High Very High
Myocardial Infarction 22 99.92 Very High Very High Very High
Pressure And Volume Under Development 17 99.92 Very High Very High Very High
Cv General 4 Under Development 3 99.92 Very High Very High Very High
Cancer 231 99.84 Very High Very High Very High
Disease 219 99.84 Very High Very High Very High
Osteoporosis 3 99.84 Very High Very High Very High
Apoptosis 205 99.60 Very High Very High Very High
Necrosis 24 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of cyclooxygenase-2 causes an enhancement of writhing response in mice.
Positive_regulation (Induction) of cyclooxygenase-2 associated with cox2
1) Confidence 0.70 Published 1998 Journal Eur. J. Pharmacol. Section Title Doc Link 9718266 Disease Relevance 0 Pain Relevance 0.25
This was accompanied by alterations in the microbiota and an upregulation of cyclooxygenase-2 which could be reversed by treatment with anti-inflammatory agents or selected probiotics.
Positive_regulation (upregulation) of cyclooxygenase-2
2) Confidence 0.69 Published 2009 Journal Dig Dis Section Body Doc Link 20203502 Disease Relevance 0.07 Pain Relevance 0
PGHS-2 is not expressed in stomach but is increased by inflammatory cytokines in cells such as macrophages.
Neg (not) Positive_regulation (increased) of PGHS-2 in macrophages associated with inflammation and cytokine
3) Confidence 0.67 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.33 Pain Relevance 0.51
PGH synthase-2 is undetectable in most cells but can be induced in fibroblasts, endothelial cells, ovarian follicles, and macrophages by various mitogens, cytokines, and tumor promoters.
Positive_regulation (induced) of PGH synthase-2 in macrophages associated with cancer and cytokine
4) Confidence 0.67 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.32 Pain Relevance 0.31
E. splendens (5-100 microg/mL) significantly inhibited PGE2 production by pre-induced cyclooxygenase-2 of lipopolysaccharide-treated RAW 264.7 cells, suggesting that cyclooxygenase-2 inhibition might be one of the cellular mechanisms of anti-inflammation.
Positive_regulation (induced) of cyclooxygenase-2 in RAW 264 associated with inflammation
5) Confidence 0.61 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 12723937 Disease Relevance 0.90 Pain Relevance 0.46
Cyclooxygenase 2 is induced during inflammation following brain insult and participates in inflammation-mediated neurotoxicity.
Positive_regulation (induced) of Cyclooxygenase 2 in brain associated with drug induced neurotoxicity, inflammation and cox2
6) Confidence 0.57 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.59 Pain Relevance 0.45
In particular, radiation-induced neuroinflammation is associated with an elevation in cyclooxygenase 2 (COX2), one of two isoforms of the obligate enzyme in prostanoid synthesis and the principal target of non-steroid anti-inflammatory drugs.
Positive_regulation (elevation) of cyclooxygenase 2 associated with inflammation, cinod and cox2
7) Confidence 0.52 Published 2004 Journal Radiat. Res. Section Abstract Doc Link 14731075 Disease Relevance 0.76 Pain Relevance 0.48
However, LJ was unable to suppress induction of cyclooxygenase-2 in the stimulated macrophage cells.
Positive_regulation (induction) of cyclooxygenase-2 in macrophage
8) Confidence 0.48 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18498715 Disease Relevance 0.16 Pain Relevance 0.24
PGHS1 and PGHS2 coexist in the vasculature and in macrophages, and are upregulated together in inflammatory tissues such as rheumatoid synovia and atherosclerotic plaque.
Positive_regulation (upregulated) of PGHS2 in plaque associated with atherosclerotic plaque and inflammation
9) Confidence 0.47 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16732282 Disease Relevance 0.38 Pain Relevance 0.44
Finally, in primary cultures of rat alveolar macrophages, HN and compounds 1, 2, 6, and 7 (10(-8) M) significantly blocked lipopolysaccharide-induced cyclooxygenase-2 induction and prostaglandin E(2) secretion.
Positive_regulation (induction) of cyclooxygenase-2 in alveolar macrophages
10) Confidence 0.46 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718586 Disease Relevance 0.49 Pain Relevance 0.54
SC suppressed production of nitric oxide and induction of iNOS and cyclooxygenase-2 in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages.
Positive_regulation (induction) of cyclooxygenase-2 in macrophages
11) Confidence 0.45 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18790036 Disease Relevance 0.20 Pain Relevance 0
The prostaglandin endoperoxide H synthase isoform 2, cyclooxygenase 2 (COX-2), is induced at high levels in migratory and other responding cells by pro-inflammatory stimuli.
Positive_regulation (induced) of cyclooxygenase 2 associated with cox2 and inflammatory stimuli
12) Confidence 0.43 Published 1995 Journal Cell Section Abstract Doc Link 8521477 Disease Relevance 0.31 Pain Relevance 0.32
A possible mechanism of interaction is that nitric oxide (NO) stimulates the activity of cyclooxygenase-2 by combining with its heme component.
Positive_regulation (stimulates) of cyclooxygenase-2
13) Confidence 0.43 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178354 Disease Relevance 0.07 Pain Relevance 0.40
The prostaglandin endoperoxide H synthase isoform 2, cyclooxygenase 2 (COX-2), is induced at high levels in migratory and other responding cells by pro-inflammatory stimuli.
Positive_regulation (induced) of H synthase isoform 2 associated with cox2 and inflammatory stimuli
14) Confidence 0.40 Published 1995 Journal Cell Section Abstract Doc Link 8521477 Disease Relevance 0.31 Pain Relevance 0.32
Thus, the elevated prostaglandin level in the acute hyperplastic epidermis was very likely due to PGHS-2 induction.
Spec (likely) Positive_regulation (induction) of PGHS-2 in epidermis associated with hyperplasia
15) Confidence 0.38 Published 1995 Journal Mol. Carcinog. Section Abstract Doc Link 7818763 Disease Relevance 1.04 Pain Relevance 0.22
Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain.
Positive_regulation (dependent) of cyclooxygenase 2 in brain associated with pressure and volume under development and cox2
16) Confidence 0.38 Published 2004 Journal Radiat. Res. Section Title Doc Link 14731075 Disease Relevance 0.76 Pain Relevance 0.49
However, EVA could not suppress induction of cyclooxygenase-2 in the LPS-activated macrophages.
Positive_regulation (induction) of cyclooxygenase-2 in macrophages
17) Confidence 0.35 Published 2010 Journal Arch. Pharm. Res. Section Abstract Doc Link 20195833 Disease Relevance 0.30 Pain Relevance 0.24
Cyclooxygenase-2, one of target molecules of these drugs, is reported to be upregulated in cancer tissues.
Positive_regulation (upregulated) of Cyclooxygenase-2 associated with cancer
18) Confidence 0.32 Published 2001 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 11729471 Disease Relevance 0.55 Pain Relevance 0.04
Acute inflammation follows defined phases of induction, inflammation and resolution, and resolution occurs by an active process that requires cyclooxygenase-2 (COX-2) activity.
Positive_regulation (requires) of cyclooxygenase-2 associated with inflammation
19) Confidence 0.32 Published 2010 Journal J. Immunol. Section Abstract Doc Link 20435922 Disease Relevance 0.59 Pain Relevance 0.29
PGH synthase-2 is undetectable in most cells but can be induced in fibroblasts, endothelial cells, ovarian follicles, and macrophages by various mitogens, cytokines, and tumor promoters.
Positive_regulation (induced) of PGH synthase-2 in endothelial cells associated with cancer and cytokine
20) Confidence 0.23 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.32 Pain Relevance 0.31

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