INT52712

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 64
Total Number 66
Disease Relevance 23.11
Pain Relevance 28.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
colon 2
myocardium 1
HL-60 1
brain 1
fibroblasts 1
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 893 100.00 Very High Very High Very High
Morphine 23 99.98 Very High Very High Very High
Painful diabetic neuropathy 1 99.84 Very High Very High Very High
Nicotine 27 99.62 Very High Very High Very High
Calcium channel 3 99.60 Very High Very High Very High
Opioid 29 99.58 Very High Very High Very High
5HT 141 99.56 Very High Very High Very High
Pain 33 99.50 Very High Very High Very High
mu opioid receptor 8 99.36 Very High Very High Very High
opiate 13 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 4 99.84 Very High Very High Very High
Infection 65 99.52 Very High Very High Very High
Virus Diseases 178 99.32 Very High Very High Very High
Apoptosis 170 99.28 Very High Very High Very High
Lung Cancer 18 99.08 Very High Very High Very High
Bullous Skin Disease 608 99.00 Very High Very High Very High
Pulmonary Embolism 22 98.96 Very High Very High Very High
Sprains And Strains 7 98.80 Very High Very High Very High
Hyperglycemia 25 98.60 Very High Very High Very High
Pain 24 98.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that nicotine, like phorbol 12-myristate 13-acetate, increased total protein kinase C (PKC) activity, while morphine and sphingosine decreased PKC activity, and nicotine reversed morphine inhibition of PKC activity.
Negative_regulation (decreased) of PKC associated with kinase c, nicotine and morphine
1) Confidence 0.57 Published 1994 Journal Cell Growth Differ. Section Abstract Doc Link 7848904 Disease Relevance 0.94 Pain Relevance 1.73
We found that nicotine, like phorbol 12-myristate 13-acetate, increased total protein kinase C (PKC) activity, while morphine and sphingosine decreased PKC activity, and nicotine reversed morphine inhibition of PKC activity.
Negative_regulation (inhibition) of PKC associated with kinase c, nicotine and morphine
2) Confidence 0.57 Published 1994 Journal Cell Growth Differ. Section Abstract Doc Link 7848904 Disease Relevance 0.95 Pain Relevance 1.75
The sustained down-regulation of PKC-alpha in the brain of opiate addicts would allow the up-regulation of G alpha(i1/2) proteins aimed at compensating the postulated desensitization of the mu-opioid receptor system.
Negative_regulation (down-regulation) of PKC-alpha in brain associated with opioid receptor and opiate
3) Confidence 0.56 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9153634 Disease Relevance 0.39 Pain Relevance 0.96
The level of Ca2+-dependent PKC-alpha was decreased (25%), whereas that of the atypical PKC-zeta remained unchanged.
Negative_regulation (decreased) of PKC-alpha
4) Confidence 0.56 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9153634 Disease Relevance 0.42 Pain Relevance 0.98
A Phase Ib trial of bryostatin 1, a macrocyclic lactone and protein kinase C (PKC) activator, was conducted in patients with refractory nonhematological malignancies with the primary goal of determining whether down-regulation of peripheral blood mononuclear cell (PBMNC) PKC activity could be achieved in vivo in humans.
Negative_regulation (regulation) of PKC in blood associated with kinase c
5) Confidence 0.55 Published 1998 Journal Clin. Cancer Res. Section Abstract Doc Link 9533528 Disease Relevance 0.30 Pain Relevance 0.25
PKC activation attenuated (P < 0.05), whereas PKC inhibition potentiated (P < 0.05), both peak and sustained CCE.
Negative_regulation (inhibition) of PKC associated with kinase c
6) Confidence 0.51 Published 2008 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 18344413 Disease Relevance 0 Pain Relevance 0.70
Our observation that blockade of PKC abolishes the protection by diazoxide does not eliminate that possibility.
Negative_regulation (blockade) of PKC associated with kinase c
7) Confidence 0.50 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.30
But again, the mechanism of preconditioning the human myocardium may not be applicable to all species as suggested by the need to combine the inhibition of PKC and tyrosine kinase to abort the protection of preconditioning in pigs. [30]
Negative_regulation (inhibition) of PKC in myocardium associated with kinase c
8) Confidence 0.50 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0.12 Pain Relevance 0.45
The mechanism of action may be mediated by inhibition of PKC.


Negative_regulation (inhibition) of PKC
9) Confidence 0.47 Published 2006 Journal Br J Anaesth Section Body Doc Link 16299047 Disease Relevance 0 Pain Relevance 0
The present study provides evidence that nicotine (a) activates the mitogen-activated protein (MAP) kinase signalling pathway in lung cancer cells, specifically extracellular signal-regulated kinase (ERK2), resulting in increased expression of the bcl-2 protein and inhibition of apoptosis in these cells; and (b) blocks the inhibition of protein kinase C (PKC) and ERK2 activity in lung cancer cells by anti-cancer agents, such as therapeutic opioid drugs, and thus can adversely affect cancer therapy.
Negative_regulation (inhibition) of PKC in lung associated with kinase c, lung cancer, cancer, nicotine, apoptosis and opioid
10) Confidence 0.43 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 0.95 Pain Relevance 0.52
Therapeutic potential of PKC inhibitors in painful diabetic neuropathy.
Negative_regulation (inhibitors) of PKC associated with pain and painful diabetic neuropathy
11) Confidence 0.43 Published 2001 Journal Expert Opin Investig Drugs Section Title Doc Link 11772275 Disease Relevance 1.25 Pain Relevance 1.25
Of the three women with pulmonary embolisms and a low risk score (0 or 1), one had a protein S deficiency, one a protein C deficiency, and one an antithrombin deficiency.
Negative_regulation (deficiency) of a protein C associated with pulmonary embolism and cva
12) Confidence 0.42 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605344 Disease Relevance 0.83 Pain Relevance 0.42
Of the three women with pulmonary embolisms and a low risk score (0 or 1), one had a protein S deficiency, one a protein C deficiency, and one an antithrombin deficiency.
Negative_regulation (deficiency) of a protein C associated with pulmonary embolism and cva
13) Confidence 0.42 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605344 Disease Relevance 0.83 Pain Relevance 0.42
Comparison of 72-h with baseline values for all three patient cohorts combined revealed a trend toward PKC down-regulation (P = 0.06; signed rank test).
Negative_regulation (down-regulation) of PKC associated with kinase c
14) Confidence 0.40 Published 1998 Journal Clin. Cancer Res. Section Abstract Doc Link 9533528 Disease Relevance 0.48 Pain Relevance 0.23
Using infection with rBDV-AASS, in which PKC interference is suppressed, will be instrumental to test whether these other pathways are still affected, allowing to gain further insight on the relationship between the different BDV targets in neurons.
Negative_regulation (suppressed) of PKC in neurons associated with virus diseases, kinase c and infection
15) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.79 Pain Relevance 0.23
The question remains open of whether the impairment of neuronal activity due to BDV infection is solely dependent on PKC inhibition.
Negative_regulation (inhibition) of PKC in neuronal associated with virus diseases, kinase c and infection
16) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 1.06 Pain Relevance 0.21
However, Pain et al [18] and Miura et al [29] using chelerythrine and calphostin C to block PKC were unable to confirm this observation in the rabbit, suggesting that these differences could arise as a result of different animal species.
Negative_regulation (block) of PKC associated with pain and kinase c
17) Confidence 0.37 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0.18 Pain Relevance 0.50
Wang et al [28] showed that PKC inhibition with chelerythrine or calphostin C completely abolished the beneficial effects of diazoxide in the isolated rat heart, thus providing further support that mitoKATP channels are upstream of PKC.
Negative_regulation (inhibition) of PKC in heart associated with kinase c
18) Confidence 0.37 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0.20 Pain Relevance 0.49
PKC inhibition with Ro 31 8220 did not affect carbachol-stimulated cAMP formation.
Negative_regulation (inhibition) of PKC associated with kinase c
19) Confidence 0.35 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7786304 Disease Relevance 0.07 Pain Relevance 0.35
Inhibitors of phospholipase C and protein kinase C (PKC) suppressed PAR2-induced sensitization of TRPV1-mediated changes in [Ca2+]i and TRPV1 currents.
Negative_regulation (Inhibitors) of PKC associated with kinase c
20) Confidence 0.34 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128844 Disease Relevance 0.50 Pain Relevance 1.43

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