INT52713

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Context Info
Confidence 0.36
First Reported 1995
Last Reported 2009
Negated 1
Speculated 3
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.23
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
neuronal 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 163 100.00 Very High Very High Very High
Morphine 1 90.96 High High
agonist 177 90.56 High High
opiate 1 90.20 High High
antagonist 3 88.44 High High
Calcium channel 1 66.80 Quite High
nMDA receptor 4 50.00 Quite Low
Neuronal excitability 2 43.36 Quite Low
long-term potentiation 1 37.08 Quite Low
cINOD 2 26.40 Quite Low
Disease Link Frequency Relevance Heat
Infection 29 99.78 Very High Very High Very High
Virus Diseases 89 99.58 Very High Very High Very High
Cervical Cancer 2 97.04 Very High Very High Very High
Neuroblastoma 1 75.00 Quite High
Cognitive Disorder 3 70.48 Quite High
Attention Deficit Hyperactivity Disorder 1 69.96 Quite High
Congenital Anomalies 2 60.32 Quite High
Borna Disease 4 50.00 Quite Low
Cancer 32 48.36 Quite Low
Reprotox - General 1 4 38.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also determined the effect of the protein kinase C (PKC) inhibitors chelerythrine (5 x 10(-5) M), calphostin C (3 x 10(-6) M) and Ro 31-8220 (10(-7) M), and the effect of PKC activation with phorbolester (10(-6) M).
Regulation (effect) of Negative_regulation (inhibitors) of PKC
1) Confidence 0.36 Published 2006 Journal Br J Anaesth Section Body Doc Link 16299047 Disease Relevance 0 Pain Relevance 0
The question remains open of whether the impairment of neuronal activity due to BDV infection is solely dependent on PKC inhibition.
Regulation (dependent) of Negative_regulation (inhibition) of PKC in neuronal associated with virus diseases, kinase c and infection
2) Confidence 0.29 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 1.06 Pain Relevance 0.21
PKC inhibition with Ro 31 8220 did not affect carbachol-stimulated cAMP formation.
Neg (not) Regulation (affect) of Negative_regulation (inhibition) of PKC associated with kinase c
3) Confidence 0.27 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7786304 Disease Relevance 0.07 Pain Relevance 0.35
In an attempt to understand the mechanism underlying the observed biphasic effect of 25OH-C, we investigated the effect of PKC inhibition on this action of 25OH-C.
Spec (investigated) Regulation (effect) of Spec (investigated) Negative_regulation (inhibition) of PKC associated with kinase c
4) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.17
Consistent with this, the results of the present study also suggest the involvement of PKC inhibition in the down-regulation of hTERT gene transcription and PKC activation in the upregulation of hTERT gene transcription.
Regulation (involvement) of Negative_regulation (inhibition) of PKC associated with kinase c
5) Confidence 0.12 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.10 Pain Relevance 0.49
undergoes almost complete and more sustained desensitization that is also partially sensitive to GF 109203X/PKC inhibition.
Spec (partially) Regulation (sensitive) of Negative_regulation (inhibition) of PKC
6) Confidence 0.12 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
, the effects of the PKA and PKC inhibitors H-89 and GF 109203X, respectively, on U46619-induced [Ca2+]i mobilization were investigated.
Spec (investigated) Regulation (effects) of Negative_regulation (inhibitors) of PKC
7) Confidence 0.12 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11

General Comments

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