INT52714

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 7.73
Pain Relevance 13.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
brain 2
patterning 2
neuronal 1
SH-SY5Y 1
thyroid 1
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 444 100.00 Very High Very High Very High
addiction 101 100.00 Very High Very High Very High
bradykinin 79 100.00 Very High Very High Very High
rheumatoid arthritis 30 100.00 Very High Very High Very High
long-term potentiation 7 100.00 Very High Very High Very High
Opioid 31 99.58 Very High Very High Very High
Neuronal excitability 8 99.56 Very High Very High Very High
ischemia 37 99.20 Very High Very High Very High
fluoxetine 13 99.08 Very High Very High Very High
antagonist 30 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 30 100.00 Very High Very High Very High
Virus Diseases 356 99.72 Very High Very High Very High
Cv Unclassified Under Development 35 99.20 Very High Very High Very High
Neuroblastoma 13 99.12 Very High Very High Very High
Down Syndrome 16 98.92 Very High Very High Very High
Disease 285 98.32 Very High Very High Very High
Metastasis 1 97.92 Very High Very High Very High
Stress 119 97.76 Very High Very High Very High
Cognitive Disorder 24 97.68 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 16 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The opioid receptor antagonist naloxone, the PKC inhibitor chelerythrine, and the L-type calcium channel antagonist nimodipine attenuated opioid-mediated effects on PKC and mu-receptor down-regulation, suggesting that this is a process partially regulated by Ca2+-dependent PKC isoforms.
Regulation (regulation) of PKC associated with kinase c, calcium channel, antagonist, narcan, opioid receptor and opioid
1) Confidence 0.61 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.08 Pain Relevance 1.66
When opioid exposure is lengthened to >12 h, both cytosolic and particulate PKC levels drop significantly below those of control-treated cells in a process we termed "reverse translocation."
Regulation (particulate) of PKC associated with kinase c and opioid
2) Confidence 0.45 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.09 Pain Relevance 1.54
According to our results, fluoxetine has a dual effect on T-cell proliferation by modulating the PKC and protein kinase A pathways.
Regulation (modulating) of PKC in T-cell associated with kinase c and fluoxetine
3) Confidence 0.44 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374716 Disease Relevance 0 Pain Relevance 0.71
Nevertheless, as BDV is likely to affect all PKC neuronal substrates in the infected neurons, the relative contribution of the decreased phosphorylation of each of these substrates, including SNAP-25, is difficult to appreciate.
Regulation (affect) of PKC in neuronal associated with virus diseases and kinase c
4) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.75 Pain Relevance 0.24
Modulation of neuronal excitability by SNAP-25, which is dependent on PKC, is thought to have crucial consequence for brain functioning [34].
Regulation (dependent) of PKC in brain associated with kinase c and neuronal excitability
5) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.53 Pain Relevance 0.23
The effects of PKC activation and inhibition, TK inhibition, and the intravenous anesthetics on CCE were assessed.
Regulation (effects) of PKC associated with kinase c
6) Confidence 0.39 Published 2008 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 18344413 Disease Relevance 0 Pain Relevance 0.51
However, both curcumin and rottlerin showed significant direct inhibition and so (indirect) PKC effects could not be differentiated in this model system.
Neg (not) Regulation (differentiated) of PKC associated with kinase c
7) Confidence 0.34 Published 2010 Journal Xenobiotica Section Abstract Doc Link 20196639 Disease Relevance 0 Pain Relevance 0.86
Our data unambiguously demonstrate the role of P as a decoy substrate interfering with PKC signaling pathway, a kinase which plays important roles in learning and behavior [25].
Regulation (interfering) of PKC associated with kinase c
8) Confidence 0.29 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.53 Pain Relevance 0.14
Submicromolar rises in [Ca2+]i produced via activation of phospholipase C (PLC) or Ca2+ channel opening, provide a mechanism by which Ca2+/calmodulin (CaM) or protein kinase C (PKC)-sensitive isoforms of adenylyl cyclase can be regulated.
Regulation (regulated) of PKC associated with kinase c
9) Confidence 0.27 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7786304 Disease Relevance 0.07 Pain Relevance 0.13
Effects on PBMNC PKC activity were heterogeneous.
Regulation (Effects) of PKC associated with kinase c
10) Confidence 0.25 Published 1998 Journal Clin. Cancer Res. Section Abstract Doc Link 9533528 Disease Relevance 0.55 Pain Relevance 0.32
Study 3 was designed as described in Figure 3 to elucidate the sequence of the participation of involvement of mitoKATP channels, PKC and p38MAPK in the signal transduction cascade of cardioprotection.
Regulation (involvement) of PKC associated with kinase c
11) Confidence 0.23 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0.24 Pain Relevance 0.25
To further verify the involvement of PKC in the Receptor Ck signaling pathway, the effect of PKC inhibitor was investigated in a situation where Receptor Ck activation was blocked.
Spec (investigated) Regulation (effect) of PKC associated with kinase c
12) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.35
Consistent with our previous reports, we showed by quantitative Western blot analysis that the phosphorylation of these two neuronal PKC targets was significantly impaired in neurons infected with rBDV-wt (Figure 2A and 2B).
Regulation (targets) of PKC in neurons associated with kinase c
13) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.29 Pain Relevance 0.32
We have identified a novel mechanism by which proteases that activate PAR2 sensitize TRPV1 through PKC.
Regulation (sensitize) of PKC associated with kinase c
14) Confidence 0.16 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128844 Disease Relevance 0.34 Pain Relevance 1.47
These results suggest that the effect of fluoxetine on the expression of hSERT is post-translational and has shown itself to be independent of PKC and PKA activity.
Neg (independent) Regulation (independent) of PKC associated with fluoxetine
15) Confidence 0.16 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289086 Disease Relevance 0.11 Pain Relevance 0.84
However, in SH-SY5Y neuroblastoma cells, DAMGO failed to desensitize ORL1 or alter membrane PKC-alpha or GRK levels.
Neg (failed) Regulation (alter) of PKC-alpha in SH-SY5Y associated with neuroblastoma
16) Confidence 0.14 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.70
Ca2+-regulated PKC
Regulation (regulated) of PKC
17) Confidence 0.12 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
At least 12 different PKC isoforms have been characterized so far, and these can be grouped into the following three subgroups: conventional PKCs (?
Regulation (different) of PKC
18) Confidence 0.12 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Indeed, it is shown that translocation of cPLA2 is dependent on [Ca2+]c elevation [143, 144], and PKC?
Regulation (dependent) of PKC
19) Confidence 0.12 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Lithium has been found to interfere with the production of thyroid hormones including the inhibition of the thyroid stimulating hormone (TSH)-responsive adenylate cyclase and PKC in thyroid cells [22-24].
Regulation (responsive) of PKC in thyroid
20) Confidence 0.12 Published 2008 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2531078 Disease Relevance 0.42 Pain Relevance 0

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