INT52722

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Context Info
Confidence 0.38
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 54
Total Number 55
Disease Relevance 48.63
Pain Relevance 27.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (RETNLB) extracellular region (RETNLB) molecular_function (RETNLB)
cellular_component (RETNLB)
Anatomy Link Frequency
macrophages 5
monocytes 3
chondrocytes 2
microglia 2
leukocytes 2
RETNLB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 637 100.00 Very High Very High Very High
cytokine 286 100.00 Very High Very High Very High
Inflammatory mediators 111 100.00 Very High Very High Very High
metalloproteinase 7 100.00 Very High Very High Very High
Neuropeptide 4 100.00 Very High Very High Very High
cerebral cortex 1 99.92 Very High Very High Very High
Pain 71 99.80 Very High Very High Very High
Hyperalgesia 12 99.66 Very High Very High Very High
dexamethasone 26 99.50 Very High Very High Very High
Inflammatory response 72 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 798 100.00 Very High Very High Very High
Pressure And Volume Under Development 30 99.96 Very High Very High Very High
Pain 66 99.80 Very High Very High Very High
Hyperalgesia 15 99.66 Very High Very High Very High
Stress 81 99.46 Very High Very High Very High
Nervous System Injury 13 99.20 Very High Very High Very High
Toxicity 8 99.02 Very High Very High Very High
Injury 98 99.00 Very High Very High Very High
Hypersensitivity 22 98.92 Very High Very High Very High
Temporomandibular Joint Syndrome 39 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its utility to locate a plain abdominal radiograph transition zone (PARTZ), especially when CETZ is inconclusive, has not been previously studied.
Localization (locate) of transition zone
1) Confidence 0.38 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC1790893 Disease Relevance 0.58 Pain Relevance 0
Pro-inflammatory cytokines released by activated immune cells signal the brain by both blood-borne and neural routes, leading to alterations in neural activity.
Localization (released) of Pro-inflammatory in immune cells associated with inflammation and cytokine
2) Confidence 0.34 Published 2003 Journal Brain Behav. Immun. Section Abstract Doc Link 12615198 Disease Relevance 0.55 Pain Relevance 0.64
Involvement of the immune system could imply the subsequent release of neuropeptides, pro-inflammatory cytokines and eicosanoids, which in turn leads to a complex cross-talk of primary and secondary generated mediators of inflammation.
Localization (release) of pro-inflammatory in immune system associated with inflammation, neuropeptide and cytokine
3) Confidence 0.34 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11698031 Disease Relevance 0.65 Pain Relevance 0.51
These activated cells release pro-inflammatory cytokines.
Localization (release) of pro-inflammatory associated with inflammation and cytokine
4) Confidence 0.34 Published 2005 Journal Lakartidningen Section Abstract Doc Link 16408393 Disease Relevance 1.01 Pain Relevance 0.80
Overuse or repetitive stretching on tendons triggered the release of pro-inflammatory mediators, which can induce expression of metalloproteinases and leads to collagen degradation.
Localization (release) of pro-inflammatory in tendons associated with inflammatory mediators and metalloproteinase
5) Confidence 0.13 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2770552 Disease Relevance 1.71 Pain Relevance 0.55
It has recently become accepted that the activated immune system communicates to brain via release of pro-inflammatory cytokines.
Localization (release) of pro-inflammatory in brain associated with inflammation and cytokine
6) Confidence 0.10 Published 1995 Journal Pain Section Abstract Doc Link 8719529 Disease Relevance 0.94 Pain Relevance 0.51
Systemic immunity was assessed by determining leucocyte counts, NK cell counts and activity, lymphocyte response to mitogen stimulation, and secretion of pro-inflammatory cytokines.
Localization (secretion) of pro-inflammatory in NK cell
7) Confidence 0.03 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 15196108 Disease Relevance 0 Pain Relevance 0
SUMMARY OF BACKGROUND DATA: Degenerate human disc tissue has been shown to spontaneously secrete a number of pro-inflammatory mediators.
Localization (secrete) of pro-inflammatory
8) Confidence 0.03 Published 2003 Journal Spine Section Body Doc Link 14673370 Disease Relevance 0.09 Pain Relevance 0
Thus, while arthroscopic procedures make surgery less invasive, the inflammatory response at the joint remains and the release of pro-inflammatory cytokines in the synovial fluid is associated with an increase in the aggrecanase activities that lead to a degradation of the cartilage matrix, and also inhibit proteoglycan synthesis [11, 15, 18].
Localization (release) of pro-inflammatory in cartilage associated with inflammatory response, inflammation and cytokine
9) Confidence 0.03 Published 2008 Journal Knee Surg Sports Traumatol Arthrosc Section Body Doc Link PMC2413121 Disease Relevance 0.92 Pain Relevance 0.53
Electromagnetic fields in vivo prevent degeneration of articular cartilage and down-regulate the synthesis and release of pro-inflammatory cytokines in the synovial fluid [2, 4, 8, 9].
Localization (release) of pro-inflammatory in synovial fluid associated with inflammation and cytokine
10) Confidence 0.03 Published 2008 Journal Knee Surg Sports Traumatol Arthrosc Section Body Doc Link PMC2413121 Disease Relevance 0.51 Pain Relevance 0.63
The extravasated blood is responsible for a cascade of reactions involving release of various vasoactive and pro-inflammatory factors (several of which are purported to induce vasospasm) from blood and vascular components in the subarachnoid space.
Localization (release) of pro-inflammatory in vascular components associated with inflammation and increased venous pressure under development
11) Confidence 0.03 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11949877 Disease Relevance 0.85 Pain Relevance 0.36
Neopterin formation by human monocyte-derived macrophages and dendritic cells is induced by the pro-inflammatory cytokine interferon-gamma, which is released by activated T-lymphocytes.
Localization (released) of pro-inflammatory in dendritic cells associated with inflammation and cytokine
12) Confidence 0.02 Published 2006 Journal Curr Vasc Pharmacol Section Abstract Doc Link 16842138 Disease Relevance 0.89 Pain Relevance 0.19
This prevents the release of pro-inflammatory mediators that produce an allergic response.
Localization (release) of pro-inflammatory associated with inflammatory mediators and hypersensitivity
13) Confidence 0.02 Published 2006 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 17319219 Disease Relevance 0.43 Pain Relevance 0.12
Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts.
Localization (secretion) of Pro-inflammatory associated with inflammation, metalloproteinase and cytokine
14) Confidence 0.02 Published 2003 Journal Pancreatology Section Title Doc Link 14526152 Disease Relevance 0.18 Pain Relevance 0.32
It has been suggested that the release of pro-inflammatory cytokines into the circulation is important in the pathogenesis of post-operative myocardial dysfunction [25-28].
Localization (release) of pro-inflammatory associated with inflammation, coronary heart disease and cytokine
15) Confidence 0.01 Published 2005 Journal Crit Care Section Body Doc Link PMC1414017 Disease Relevance 1.62 Pain Relevance 0.63
In addition to their capacity to induce pain, vasodilatation and fever, prostaglandins E (PGE) exert anti-inflammatory activities by inhibiting the release of pro-inflammatory cytokines by macrophages and T cells, and by increasing interleukin (IL)-10 production by macrophages.
Localization (release) of pro-inflammatory in T cells associated with pain, inflammation, fever, increased venous pressure under development and cytokine
16) Confidence 0.01 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.72 Pain Relevance 0.53
However, when locally deposited immune complexes activate the complement system, the cascade of biochemical events results in the release of pro-inflammatory mediators that can increase vascular permeability, draw leukocytes to the area of immune complex localization, and directly induce tissue damage.
Localization (release) of pro-inflammatory in leukocytes associated with inflammatory mediators
17) Confidence 0.01 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2877652 Disease Relevance 0.55 Pain Relevance 0.23
This activation leads to more vascular damage and tissue destruction through the release of pro-inflammatory cytokines, toxic oxygen products, and proteolytic lysosomal enzymes.
Localization (release) of pro-inflammatory associated with inflammation and cytokine
18) Confidence 0.01 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2877652 Disease Relevance 0.92 Pain Relevance 0.32
This manuscript explores the impact of two of these novel hybrid compounds and of the furazan analogues, devoid of NO-release capacity (Fig. 1c), on release of the pro-inflammatory cytokine, TNF?
Localization (release) of pro-inflammatory associated with inflammation and cytokine
19) Confidence 0.01 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.51 Pain Relevance 0.56
Our ABM predicted that the secretion of pro-inflammatory mediators would be both prolonged and elevated subsequent to spontaneous speech following an episode of phonotraumatic injury.
Localization (secretion) of pro-inflammatory associated with inflammatory mediators and injury
20) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481293 Disease Relevance 1.14 Pain Relevance 0.48

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