INT52732

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 169
Total Number 173
Disease Relevance 138.47
Pain Relevance 40.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
plasma 7
erythrocyte 7
blood 7
white blood cell 3
spine 2
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2664 100.00 Very High Very High Very High
cytokine 630 100.00 Very High Very High Very High
Pain 312 100.00 Very High Very High Very High
Angina 177 100.00 Very High Very High Very High
Inflammatory marker 147 100.00 Very High Very High Very High
Inflammatory response 117 100.00 Very High Very High Very High
abatacept 750 99.98 Very High Very High Very High
beta blocker 10 99.98 Very High Very High Very High
dexamethasone 102 99.84 Very High Very High Very High
Serotonin 42 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2922 100.00 Very High Very High Very High
Disease 1786 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 576 100.00 Very High Very High Very High
Weight Loss 269 100.00 Very High Very High Very High
Pain 267 100.00 Very High Very High Very High
Body Weight 217 100.00 Very High Very High Very High
Cv General 3 Under Development 140 100.00 Very High Very High Very High
Urological Neuroanatomy 123 100.00 Very High Very High Very High
Thyroiditis 77 100.00 Very High Very High Very High
Carcinoma 103 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this subgroup of patients, statin therapy is associated with significantly reduced intimal CRP.
Negative_regulation (reduced) of CRP
1) Confidence 0.59 Published 2002 Journal Z Kardiol Section Abstract Doc Link 12442194 Disease Relevance 0.77 Pain Relevance 0.13
But one has to keep in mind that CRP levels can be reduced with smoking cessation [15] and weight loss[16,17].
Negative_regulation (reduced) of CRP associated with weight loss and nicotine addiction
2) Confidence 0.59 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2921363 Disease Relevance 1.15 Pain Relevance 0.07
After changing the antibiotics to ceftriaxon and metronidazole, acute cholangitis being suspected, the fever subsided immediately and the CRP level decreased.
Negative_regulation (decreased) of CRP associated with cholangitis and fever
3) Confidence 0.58 Published 2007 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 17520506 Disease Relevance 0.78 Pain Relevance 0.09
Confirmation of this result was obtained in a primary prevention cohort by implementation of lovastatin therapy in the course of the Air Force/Texas Coronary Prevention Study (AFCAPS/Tex-CAPS), as well as by administration of cerivastatin to patients with primary hypercholesterolemia—both drug regimens resulted in a significant reduction of plasma CRP levels (

Ridker and others, 2001b

).

Negative_regulation (reduction) of CRP in plasma associated with hyperlipidemia
4) Confidence 0.57 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688374 Disease Relevance 0.29 Pain Relevance 0.06
They can not be uniformly interpreted across tumor entities as demonstrated in our example of HRPC in comparison to other tumors, when inflammation seems to be quite differently integrated in the tumors’ pathophysiology: PSA decline was paralleled but not preceded by a CRP decline in HRPC, whereas in other tumor types including RCCC decrease of CRP or ECOG performance improvement preceded tumor response.
Negative_regulation (decrease) of CRP associated with inflammation, cancer, carcinoma and dexamethasone
5) Confidence 0.57 Published 2008 Journal Cancer Microenviron Section Body Doc Link PMC2654356 Disease Relevance 2.09 Pain Relevance 0.21
In HRPC, a CRP decrease was always paralleled by PSA response, whereas CRP response and/or ECOG improvement preceded objective responses by months (3.1 months to 8.6 months) in all other trials with the exception of individual patients with vascular sarcomas [8].
Negative_regulation (decrease) of CRP associated with sarcoma and reprotox - general 1
6) Confidence 0.57 Published 2008 Journal Cancer Microenviron Section Body Doc Link PMC2654356 Disease Relevance 2.38 Pain Relevance 0.34
Several randomized trials have shown that pravastatin 40 mg daily reduced CRP concentrations significantly [12,13,43], but there is no dose-response information for this response.
Negative_regulation (reduced) of CRP
7) Confidence 0.55 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.25 Pain Relevance 0.14
Studies that have examined the effects of statins on cytokine production ex vivo have done so after several weeks of treatment [12] and thus have not separated out direct antiinflammatory effects from those due to the reduction in lipids and CRP [31].
Negative_regulation (reduction) of CRP associated with inflammation and cytokine
8) Confidence 0.55 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.41 Pain Relevance 0.24
TNFalpha antagonist therapy induces a significant decrease in MMP-3 levels, together with decreases in conventional variables (ESR, CRP, and BASDAI).
Negative_regulation (decreases) of CRP
9) Confidence 0.52 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0 Pain Relevance 0
Thus, the use of insulin or OHAs could have artificially lowered hs-CRP levels in subjects with diabetes, making a difference between the groups difficult to detect.
Negative_regulation (lowered) of hs-CRP associated with diabetes mellitus
10) Confidence 0.51 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.35 Pain Relevance 0.09
decreases in hs-CRP were observed in patients with higher baseline
Negative_regulation (decreases) of hs-CRP
11) Confidence 0.50 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 2.19 Pain Relevance 0.03
Within the placebo cohort (Table 3), the majority of patients (n = 10) did not exhibit any meaningful CRP reduction (<20%); however, CRP was reduced by more than 50% in three patients, but this was not associated with an ACR20 response.
Negative_regulation (reduced) of CRP
12) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 0 Pain Relevance 0.03
In the current study, CRP reduction was found to be necessary for achievment of clinical response, as expected, but it was not sufficient to explain or even predict clinical response, because CRP reduction was also observed in the absence of clinical response.
Negative_regulation (reduction) of CRP
13) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 0.29 Pain Relevance 0.09
Similarly, CRP was also reduced upon treatment in the other active treatment cohorts (data not shown).
Negative_regulation (reduced) of CRP
14) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 0 Pain Relevance 0.04
As demonstrated in Table 3 for the 10 mg/kg cohort, a reduction in CRP at day 43 was required to achieve a ACR20 or higher response; however, eight subjects had a more than 50% reduction in CRP but had no detectable clinical response based on ACR20 criteria.
Negative_regulation (reduction) of CRP
15) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 0 Pain Relevance 0.04
The study provides evidence of a treatment effect by demonstrating that 50% of patients achieved an ACR20 response up to day 43 in the highest tested dose of 10 mg/kg intravenous, along with a robust reduction in serum CRP.
Negative_regulation (reduction) of CRP
16) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 0.25 Pain Relevance 0.24
As demonstrated in Table 3 for the 10 mg/kg cohort, a reduction in CRP at day 43 was required to achieve a ACR20 or higher response; however, eight subjects had a more than 50% reduction in CRP but had no detectable clinical response based on ACR20 criteria.
Negative_regulation (reduction) of CRP
17) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 0 Pain Relevance 0.04
CT scan carried out two weeks after surgery showed a marked reduction in the size of the collection and a decrease in the CRP level to 16 mg/L at the same time.
Negative_regulation (decrease) of CRP
18) Confidence 0.45 Published 2010 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC2828987 Disease Relevance 0.91 Pain Relevance 0.10
However, adjustment for BMI (which had the most potent attenuating effect) is unlikely to represent an overadjustment, since weight gain is associated with an increase in CRP, and weight loss with a CRP reduction [49]–[51].
Negative_regulation (reduction) of CRP associated with weight loss and weight gain
19) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.79 Pain Relevance 0.04
But data on CRP levels in saliva of HT and SAT patients are lacking in literature.
Negative_regulation (lacking) of CRP in saliva associated with thyroiditis
20) Confidence 0.43 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2989710 Disease Relevance 1.49 Pain Relevance 0.25

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