INT52747

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Context Info
Confidence 0.30
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.54
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 2
alp (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 3 100.00 Very High Very High Very High
Paracetamol 9 84.80 Quite High
cva 5 79.12 Quite High
Bile 1 53.52 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
complementary and alternative medicine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 7 100.00 Very High Very High Very High
Injury 5 99.88 Very High Very High Very High
Toxicity 20 99.04 Very High Very High Very High
Nephrotoxicity 3 91.12 High High
Death 4 81.68 Quite High
Renal Disease 1 80.80 Quite High
Hemorrhage 4 79.12 Quite High
Diarrhoea 8 77.28 Quite High
Post-partum Hemorrhage 1 65.24 Quite High
Bone Cancer 1 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P. niruri significantly reduced the elevated glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels in the sera of toxicity induced mice, compared with the control group.
Negative_regulation (reduced) of Positive_regulation (elevated) of ALP associated with toxicity and glutamate
1) Confidence 0.30 Published 2006 Journal Phytother Res Section Abstract Doc Link 16718736 Disease Relevance 0.37 Pain Relevance 0.43
Pretreatment of rats with plant extract (500 mg/kg) significantly lowered (P < 0.05) the respective serum ALP; GOT and GPT levels to 192 +/- 31, 63 +/- 9 and 35 +/- 8. 5.
Negative_regulation (lowered) of Positive_regulation (respective) of ALP
2) Confidence 0.11 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.24 Pain Relevance 0.40
These symptoms were revealed by characteristic biochemical markers such as the increase in the serum creatinine level and the phosphorus concentration for kidney injury, the increase in ALP and GGT levels for liver damage, and the decrease in serum proteins for nutrient deficiency [29–32].
Negative_regulation (decrease) of Positive_regulation (increase) of ALP in liver associated with injury and hepatotoxicity
3) Confidence 0.10 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 0.93 Pain Relevance 0.13

General Comments

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