INT52748

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Context Info
Confidence 0.30
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.64
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
internal 1
body 1
alp (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 7 100.00 Very High Very High Very High
Paracetamol 9 84.80 Quite High
cINOD 2 81.92 Quite High
Inflammatory response 2 78.56 Quite High
Inflammatory mediators 2 73.44 Quite High
cytokine 2 45.76 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 9 99.04 Very High Very High Very High
Body Weight 33 98.72 Very High Very High Very High
Injury 46 97.64 Very High Very High Very High
Burns 44 89.12 High High
Hepatotoxicity 6 84.68 Quite High
Death 3 81.68 Quite High
INFLAMMATION 15 81.52 Quite High
Stress 8 77.72 Quite High
Wound Healing 10 77.04 Quite High
Granuloma 12 65.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P. niruri significantly reduced the elevated glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels in the sera of toxicity induced mice, compared with the control group.
Negative_regulation (reduced) of ALP associated with toxicity and glutamate
1) Confidence 0.30 Published 2006 Journal Phytother Res Section Abstract Doc Link 16718736 Disease Relevance 0.37 Pain Relevance 0.43
Administration of aqueous stem extract (400 mg/kg body weight, orally) and aqueous leaves extract (400 mg/kg body weight, orally) along with the lead nitrate (5 mg/kg body weight, i.p. for 30 days) increased the activities of SOD and CAT and decreased the levels of AST, ALT, ALP, and ACP enzymes in mice.
Negative_regulation (decreased) of ALP in body associated with body weight
2) Confidence 0.29 Published 2010 Journal Toxicology International Section Abstract Doc Link PMC2964743 Disease Relevance 0.52 Pain Relevance 0
Pretreatment of rats with plant extract (500 mg/kg) significantly lowered (P < 0.05) the respective serum ALP; GOT and GPT levels to 192 +/- 31, 63 +/- 9 and 35 +/- 8. 5.
Negative_regulation (lowered) of ALP
3) Confidence 0.11 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.24 Pain Relevance 0.40
The administration of Calendula officinalis extract significantly decreased the serum level of marker enzymes of tissue damage like ALP, GOT and GPT indicating that Calendula extract reduce the injury of the internal organs during thermal burning.
Negative_regulation (decreased) of ALP in internal associated with injury
4) Confidence 0.05 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2533690 Disease Relevance 1.03 Pain Relevance 0.16
Serum ALP activity was significantly increased in burned animals and was found to be significantly lowered by Calendula treatment (TableĀ 4).
Negative_regulation (lowered) of ALP
5) Confidence 0.05 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2533690 Disease Relevance 0.49 Pain Relevance 0

General Comments

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