INT52749

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 12.84
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 3
bile duct 2
plasma 2
kidney 2
dentin 2
alp (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 204 99.56 Very High Very High Very High
Paracetamol 56 99.38 Very High Very High Very High
aspirin 42 98.76 Very High Very High Very High
abdominal pain 2 97.52 Very High Very High Very High
cva 30 94.64 High High
Pain 2 93.04 High High
headache 1 90.76 High High
dexamethasone 6 87.60 High High
Glutamate 2 84.00 Quite High
fibrosis 7 52.08 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 50 98.98 Very High Very High Very High
Body Weight 26 98.44 Very High Very High Very High
Diarrhoea 48 98.24 Very High Very High Very High
Abdominal Pain 2 97.52 Very High Very High Very High
Toxicity 142 97.44 Very High Very High Very High
Hypesthesia 2 97.32 Very High Very High Very High
Paralysis 1 96.80 Very High Very High Very High
Cancer 49 95.40 Very High Very High Very High
Hemorrhage 24 94.64 High High
Death 50 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High levels of ALP (HR: 1.68, 95% CI: 1.09–2.59, p = 0.019), low levels of albumin (HR: 2.17, 95% CI: 1.27–3.69, p = 0.004) and CA 19-9 ?
Gene_expression (levels) of ALP
1) Confidence 0.44 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2865167 Disease Relevance 0.75 Pain Relevance 0
Administration of aqueous stem extract (400 mg/kg body weight, orally) and aqueous leaves extract (400 mg/kg body weight, orally) along with the lead nitrate (5 mg/kg body weight, i.p. for 30 days) increased the activities of SOD and CAT and decreased the levels of AST, ALT, ALP, and ACP enzymes in mice.
Gene_expression (levels) of ALP in body associated with body weight
2) Confidence 0.40 Published 2010 Journal Toxicology International Section Abstract Doc Link PMC2964743 Disease Relevance 0.51 Pain Relevance 0
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Gene_expression (expression) of ALP in dentin
3) Confidence 0.36 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Gene_expression (levels) of ALP in dentin
4) Confidence 0.28 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04
C-PTH and ALP were significantly higher in the non-improved group.
Gene_expression (higher) of ALP
5) Confidence 0.26 Published 1996 Journal Hinyokika Kiyo Section Abstract Doc Link 8712083 Disease Relevance 0.38 Pain Relevance 0.09
Laboratory findings showed that ALP, LDH and CRP were higher than normal.
Gene_expression (higher) of ALP
6) Confidence 0.22 Published 2002 Journal Masui Section Abstract Doc Link 12428322 Disease Relevance 1.25 Pain Relevance 0.09
Serum AST, ALT and ALP levels (u/l) significantly increased [P < 0.05] following paracetamol administration.
Gene_expression (levels) of ALP associated with paracetamol
7) Confidence 0.21 Published 2007 Journal Niger J Physiol Sci Section Abstract Doc Link 18379621 Disease Relevance 0.07 Pain Relevance 0.82
Caffeination as well as administration of vitamins A and E caused significant decreases[P < 0.05] in AST and ALP levels in all test groups when co-administered with paracetamol and in ALT level except in the caffeinated paracetamol + Vitamin E group in which ALT and ALP level except in the caffeinated paracetamol + vitamin E group in which ALT and ALP levels significantly increased [P < 0.05].
Gene_expression (levels) of ALP associated with paracetamol
8) Confidence 0.21 Published 2007 Journal Niger J Physiol Sci Section Abstract Doc Link 18379621 Disease Relevance 0.07 Pain Relevance 0.98
To demonstrate the expression of the ES cell marker ALP in GF-derived iPS cell colonies, a standard ALP staining protocol was used [46].
Gene_expression (expression) of ALP
9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
The hepatotoxic dose of CCl4 (1.5 ml/kg; orally) raised serum ALP, GOT and GPT levels to 328 +/- 30, 493 +/- 102 and 357 +/- 109 IU/l (n = 10) respectively, compared to respective control values of 177 +/- 21, 106 +/- 15 and 47 +/- 12. 6.
Gene_expression (raised) of ALP
10) Confidence 0.18 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.23 Pain Relevance 0.37
Alkaline phosphatase (ALP) is present in all tissues, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta.
Gene_expression (concentrated) of ALP in bile duct associated with bile
11) Confidence 0.17 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 1.03 Pain Relevance 0.14
Alkaline phosphatase (ALP) is present in all tissues, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta.
Gene_expression (present) of ALP in bile duct associated with bile
12) Confidence 0.17 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 1.01 Pain Relevance 0.14
The underlying mechanisms of aspirin effect on bone metabolism appear to correlate with increased expression of certain osteogenic genes including Runx2, a master gene for osteogenic differentiation, ALP, and OCN (Fig. 3O).
Gene_expression (expression) of ALP associated with aspirin
13) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 0 Pain Relevance 0.46
Oral administration of paracetamol (640 mg kg-1) produced liver damage in rats as manifested by the rise in serum enzyme levels of alkaline phosphatase (ALP) and aminotransferases (AST and ALT).
Gene_expression (levels) of ALP in liver associated with paracetamol and hepatotoxicity
14) Confidence 0.08 Published 1998 Journal Pharmacol. Res. Section Abstract Doc Link 9503477 Disease Relevance 0.27 Pain Relevance 0.44
APAP exposure increased the plasma levels of ALT, ALP, LDH, TNF-alpha and NO production.
Gene_expression (levels) of ALP in plasma associated with paracetamol
15) Confidence 0.06 Published 2010 Journal Free Radic. Res. Section Abstract Doc Link 20166895 Disease Relevance 0.63 Pain Relevance 0.73
Alkaline phosphatase (ALP) is present in all tissues, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta.
Gene_expression (present) of ALP in kidney associated with bile
16) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 1.01 Pain Relevance 0.14
Alkaline phosphatase (ALP) is present in all tissues, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta.
Gene_expression (concentrated) of ALP in liver associated with bile
17) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 1.03 Pain Relevance 0.14
Alkaline phosphatase (ALP) is present in all tissues, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta.
Gene_expression (present) of ALP in liver associated with bile
18) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 1.01 Pain Relevance 0.14
Alkaline phosphatase (ALP) is present in all tissues, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta.
Gene_expression (concentrated) of ALP in kidney associated with bile
19) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 1.03 Pain Relevance 0.14
The ALP levels followed the same trends for all three groups (Figure 8).
Gene_expression (levels) of ALP
20) Confidence 0.05 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC1828073 Disease Relevance 0.33 Pain Relevance 0

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