INT52755

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.57
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sptan1) plasma membrane (Sptan1) cytoskeleton (Sptan1)
protein complex (Sptan1) cytoplasm (Sptan1)
Anatomy Link Frequency
neurons 1
lung 1
RT4 1
Sptan1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 26 100.00 Very High Very High Very High
fibrosis 6 100.00 Very High Very High Very High
Cannabinoid 3 100.00 Very High Very High Very High
agonist 8 99.38 Very High Very High Very High
substance P 9 97.44 Very High Very High Very High
Nerve growth factor 1 95.40 Very High Very High Very High
opioid receptor 5 93.44 High High
Dopamine 4 90.88 High High
corticosteroid 1 90.88 High High
MU agonist 4 90.08 High High
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 6 100.00 Very High Very High Very High
Cough 9 99.52 Very High Very High Very High
Sprains And Strains 5 99.40 Very High Very High Very High
Frailty 1 98.58 Very High Very High Very High
Congenital Anomalies 1 60.52 Quite High
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, DT-II and DPDPE inhibit A2a adenosine-stimulated adenylyl cyclase (antagonized by NTB and BNTX, respectively), whereas DAMGO did not inhibit A2a adenosine-stimulated adenylyl cyclase activity.
Positive_regulation (stimulated) of A2a associated with adenocard
1) Confidence 0.67 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7790855 Disease Relevance 0 Pain Relevance 0.94
In contrast, the delta 2 agonist, DT-II, inhibited both D1 and A2a activated enzyme in all strains except DBA/2J, where DT-II did not inhibit D1-activated adenylyl cyclase.
Positive_regulation (activated) of A2a associated with agonist and sprains and strains
2) Confidence 0.49 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738226 Disease Relevance 0.33 Pain Relevance 0.79
Besides the well-characterized inhibitory effect of adenosine in the gastrointestinal tract mediated by A1 receptors, we recently demonstrated that endogenously generated adenosine facilitates [3H]acetylcholine release from myenteric neurons through preferential activation of prejunctional A2A receptors.
Positive_regulation (activation) of A2A in neurons associated with adenocard
3) Confidence 0.49 Published 2006 Journal Auton Neurosci Section Abstract Doc Link 16563876 Disease Relevance 0 Pain Relevance 0.41
Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors.
Positive_regulation (activation) of A2A associated with adenocard, cannabinoid and frailty
4) Confidence 0.45 Published 2007 Journal Eur. J. Neurosci. Section Title Doc Link 17672854 Disease Relevance 0.10 Pain Relevance 0.68
Reverse transcription-polymerase chain reaction of mRNA isolated from RT4-B8 cells demonstrated the presence of rat cardiac (rH1) and brain IIa alpha-subunit mRNA, as well as mRNA for the Na channel beta 1-subunit.
Positive_regulation (presence) of brain IIa alpha-subunit mRNA in RT4
5) Confidence 0.14 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8967455 Disease Relevance 0 Pain Relevance 0.10
These findings suggest functional upregulation of lung sensory neurones in IPF.
Positive_regulation (upregulation) of IPF in lung associated with fibrosis
6) Confidence 0.03 Published 2003 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 12917229 Disease Relevance 1.13 Pain Relevance 0.90

General Comments

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