INT52756

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.31
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sptan1) plasma membrane (Sptan1) cytoskeleton (Sptan1)
protein complex (Sptan1) cytoplasm (Sptan1)
Anatomy Link Frequency
plasma 1
Sptan1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 17 99.96 Very High Very High Very High
agonist 9 99.82 Very High Very High Very High
Dopamine 10 98.30 Very High Very High Very High
Morphine 13 97.20 Very High Very High Very High
opioid receptor 8 91.76 High High
MU agonist 5 90.40 High High
antagonist 4 88.08 High High
Substantia nigra 1 79.28 Quite High
dopamine receptor 3 75.00 Quite High
alcohol 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 10 99.20 Very High Very High Very High
Apoptosis 165 87.04 High High
Poisoning 1 64.48 Quite High
Cv Unclassified Under Development 5 62.12 Quite High
Stress 11 51.44 Quite High
Toxicity 4 50.00 Quite Low
Death 31 46.48 Quite Low
Cancer 3 30.28 Quite Low
Disease 17 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, DT-II and DPDPE inhibit A2a adenosine-stimulated adenylyl cyclase (antagonized by NTB and BNTX, respectively), whereas DAMGO did not inhibit A2a adenosine-stimulated adenylyl cyclase activity.
Negative_regulation (inhibit) of A2a associated with adenocard
1) Confidence 0.42 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7790855 Disease Relevance 0 Pain Relevance 0.94
Since dopamine D2 receptors and the mRNA for preproenkephalin also decreased there appears to be a loss of A2A-D2 receptor-bearing striatopallidal cells.
Negative_regulation (loss) of A2A associated with dopamine
2) Confidence 0.42 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593882 Disease Relevance 0 Pain Relevance 0.30
In contrast, the delta 2 agonist, DT-II, inhibited both D1 and A2a activated enzyme in all strains except DBA/2J, where DT-II did not inhibit D1-activated adenylyl cyclase.
Negative_regulation (inhibited) of A2a associated with agonist and sprains and strains
3) Confidence 0.41 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738226 Disease Relevance 0.33 Pain Relevance 0.79
In all tested mouse strains, the delta 1 selective agonist, DPDPE, inhibited the A2a-activated adenylyl cyclase but not the D1-activated enzyme.
Negative_regulation (inhibited) of A2a associated with agonist and sprains and strains
4) Confidence 0.41 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738226 Disease Relevance 0.32 Pain Relevance 0.76
In protocol 2, after the sodium cromoglycate, while control group of rats (n=8) recevied a dextrose solution, treatment groups of rats were administered DPCPX (20 microg/kg/min, n=8) or CSC (24 microg/kg/min, n=8) infusion to block adenosine A1 and A2a receptors for 20 minutes before amitriptyline infusion.
Negative_regulation (block) of A2a
5) Confidence 0.41 Published 2004 Journal J. Toxicol. Clin. Toxicol. Section Body Doc Link 15641640 Disease Relevance 0.19 Pain Relevance 0
The decrease in the abundance of non-erythroid alpha II-spectrin in the synaptic plasma-membrane fraction was also observed, which was hypothetically associated with the breakdown of the protein due to the upregulation of the proteolytic enzyme caspase-3 upon chronic morphine exposure.
Negative_regulation (decrease) of non-erythroid alpha II-spectrin in plasma associated with morphine
6) Confidence 0.31 Published 2005 Journal J Mass Spectrom Section Abstract Doc Link 15706614 Disease Relevance 0 Pain Relevance 0.40
The other possibility of AQP inactivation could be via the cytoskeleton associated anchor protein fodrin.
Negative_regulation (inactivation) of fodrin
7) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.48 Pain Relevance 0

General Comments

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