INT52775

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 6.87
Pain Relevance 11.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Anatomy Link Frequency
neurons 4
Visceral 1
spinal cord 1
nerve 1
neuroendocrine cells 1
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 338 100.00 Very High Very High Very High
nud 41 99.82 Very High Very High Very High
dorsal root ganglion 127 99.60 Very High Very High Very High
Spinal cord 136 99.36 Very High Very High Very High
antagonist 35 99.34 Very High Very High Very High
substance P 17 99.12 Very High Very High Very High
Neuropeptide 1 99.12 Very High Very High Very High
c fibre 176 99.04 Very High Very High Very High
analgesia 59 98.00 Very High Very High Very High
depression 22 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dyspepsia 41 99.82 Very High Very High Very High
Ganglion Cysts 140 99.60 Very High Very High Very High
Nociception 131 98.36 Very High Very High Very High
Nervous System Injury 98 98.36 Very High Very High Very High
Depression 16 97.48 Very High Very High Very High
Targeted Disruption 2 93.72 High High
INFLAMMATION 160 93.16 High High
Pain 109 86.84 High High
Hypoalagesia 8 81.36 Quite High
Neuropathic Pain 50 77.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The naturally occurring diterpene resiniferatoxin (RTX) is an ultrapotent analogue of capsaicin.
Positive_regulation (occurring) of RTX associated with qutenza
1) Confidence 0.42 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7790875 Disease Relevance 0 Pain Relevance 0.31
A high concentration of resiniferatoxin inhibits ion channel function in clonal neuroendocrine cells.
Positive_regulation (concentration) of resiniferatoxin in neuroendocrine cells associated with qutenza
2) Confidence 0.20 Published 2008 Journal Anesth. Analg. Section Title Doc Link 18635503 Disease Relevance 0.09 Pain Relevance 0.33
The actions of RTX are manifested in both A?
Positive_regulation (actions) of RTX
3) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.15 Pain Relevance 0.48
In the present study, we have demonstrated that the ultrapotent capsaicin analog resiniferatoxin (RTX) desensitized rat DRG neurons to the subsequent induction of 45Ca uptake by capsaicin and RTX with affinity and cooperativity similar to that found for [3H]RTX binding, contrasting with a approximately 10-fold weaker potency and lack of cooperativity to induce 45Ca uptake.
Positive_regulation (induction) of RTX in neurons associated with dorsal root ganglion, qutenza and potency
4) Confidence 0.15 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9204943 Disease Relevance 0.27 Pain Relevance 0.53
Thus, RTX produced marked and prolonged impairment of capsaicin-sensitive afferents and upregulation of the inhibitory neuropeptides GMAP and galanin in DRG neurons, which may underlie the prolonged effect of RTX.
Spec (may) Positive_regulation (underlie) of RTX in neurons associated with dorsal root ganglion, qutenza and neuropeptide
5) Confidence 0.15 Published 1997 Journal Brain Res. Section Abstract Doc Link 9106440 Disease Relevance 0.40 Pain Relevance 0.79
We observe that peripherally administered RTX temporarily eliminates behavioral responses to both A?
Positive_regulation (peripherally) of RTX
6) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.16 Pain Relevance 0.51
Consistent with the transient increase in MCP-1 following peripheral RTX, we observed that expression of the c-fos gene, measured by c-Fos protein immunostaining, was transiently increased in the spinal cord immediately after intraplantar RTX injection, consistent with our previous findings [17].
Positive_regulation (increase) of RTX in spinal cord associated with spinal cord
7) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.56 Pain Relevance 0.35
The results indicate that CAP and high concentrations of RTX are more neurotoxic to cultured rat DRG neurons while the inability of the neurons to express SP or TRPV1 after acute exposure to the lower concentration of RTX could be partially reversed after a period of incubation.
Positive_regulation (concentration) of RTX in neurons associated with dorsal root ganglion, qutenza and substance p
8) Confidence 0.11 Published 2010 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 20383340 Disease Relevance 0.44 Pain Relevance 1.27
The results indicate that CAP and high concentrations of RTX are more neurotoxic to cultured rat DRG neurons while the inability of the neurons to express SP or TRPV1 after acute exposure to the lower concentration of RTX could be partially reversed after a period of incubation.
Positive_regulation (concentrations) of RTX in neurons associated with dorsal root ganglion, qutenza and substance p
9) Confidence 0.10 Published 2010 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 20383340 Disease Relevance 0.46 Pain Relevance 1.33
Perineural RTX partially depletes TRPV1- immunopositive cells in sensory ganglia
Positive_regulation (Perineural) of RTX in ganglia
10) Confidence 0.09 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.32 Pain Relevance 0.44
Having demonstrated the unique properties of RTX at the first sensory synapse in the spinal cord and CSTN, we hypothesized that RTX-induced sustained activation of TRPV1 at the presynaptic terminal would cause analgesia by depression of synaptic transmission in the short-term and by nerve terminal ablation in the long-term.
Positive_regulation (activation) of RTX-induced in nerve associated with depression, analgesia and spinal cord
11) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.53 Pain Relevance 0.89
The selectivity of action was tested using a TRPV1 antagonist (BCTC 500 nM) that reversed the RTX-induced increase in the frequency of sEPSCs (Fig.
Positive_regulation (increase) of RTX-induced associated with antagonist
12) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0 Pain Relevance 0.55
RTX is derived from latex of the cactus Euphorbium resinifera and is the most potent of all known natural and synthetic agonists for TRPV1 [16].
Positive_regulation (derived) of RTX associated with agonist
13) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.40 Pain Relevance 0.74
In the rat skin, both ruthenium red and capsazepine (10/100 microM) reduced and abolished, respectively, capsaicin-induced iCGRP release while I-RTX (1/10 microM) was ineffective.
Positive_regulation (ineffective) of I-RTX in skin associated with qutenza
14) Confidence 0.05 Published 2004 Journal Pain Section Abstract Doc Link 15157689 Disease Relevance 0.17 Pain Relevance 0.39
Second, very high concentrations of CAP but not RTX (>10 ?
Positive_regulation (concentrations) of RTX associated with qutenza
15) Confidence 0.04 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.70
Bupivacaine but not RTX inhibits microglial proliferation after SNI
Positive_regulation (Bupivacaine) of RTX associated with nervous system injury
16) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.27 Pain Relevance 0.40
In one BR, RTX concentration was increased to 10 ?
Positive_regulation (increased) of RTX
17) Confidence 0.03 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.16 Pain Relevance 0.75
Visceral hypersensitivity present following RTX treatment
Positive_regulation (following) of RTX in Visceral associated with nud
18) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 1.33 Pain Relevance 0.71

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox