INT52785

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 0.33
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (G2e3) Golgi apparatus (G2e3) intracellular (G2e3)
cytoplasm (G2e3)
Anatomy Link Frequency
plasma 1
blood 1
outflow 1
G2e3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 41 98.82 Very High Very High Very High
tolerance 4 96.92 Very High Very High Very High
antinociception 7 95.44 Very High Very High Very High
Antinociceptive 3 87.60 High High
Intracerebroventricular 1 75.00 Quite High
opioid receptor 1 72.84 Quite High
Bile 3 56.96 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 6 72.20 Quite High
Gallstones 4 71.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our data also indicate that chloramphenicol inhibited the biliary secretion of M3G.
Localization (secretion) of M3G
1) Confidence 0.66 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10640523 Disease Relevance 0 Pain Relevance 1.62
The concentration of morphine, normorphine and morphine-3-glucuronide (M3G) in outflow perfusate, and the biliary excretion of M3G and normorphine glucuronide, all reached steady-state levels within 15-20 min after commencing perfusion.
Localization (excretion) of M3G in outflow associated with morphine
2) Confidence 0.47 Published 1995 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 7791033 Disease Relevance 0 Pain Relevance 0.64
The urinary excretion of M3G was similar in the two groups (10.1 +/- 6.8% vs 10.9 +/- 4.9%).
Localization (excretion) of M3G
3) Confidence 0.22 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487213 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: In STZ-diabetic rats, the distribution volume of morphine increased, the glucuronidation rate and M3G transportation into the blood were enhanced, and the excretion of M3G was decreased, leading to an increase in the plasma M3G concentration.


Localization (excretion) of M3G in blood
4) Confidence 0.22 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487213 Disease Relevance 0.05 Pain Relevance 0
The concentration of M3G in plasma was higher in STZ-diabetic than control rats, and the biliary excretion of M3G was lower in the STZ-diabetic rats (7.4 +/- 2.3% vs 13.3 +/- 2.0%).
Localization (excretion) of M3G in plasma
5) Confidence 0.19 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487213 Disease Relevance 0.07 Pain Relevance 0
The urinary excretion of M3G was increased significantly after BDL.
Localization (excretion) of M3G
6) Confidence 0.19 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703370 Disease Relevance 0.07 Pain Relevance 0
However, M3G disposition 1 day after BDL was similar to that in the untreated control group because urinary excretion of M3G increased.


Localization (excretion) of M3G
7) Confidence 0.17 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703370 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox