INT52789

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Context Info
Confidence 0.30
First Reported 1993
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.90
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T cells 6
spleen 2
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 12 99.64 Very High Very High Very High
cytokine 125 93.28 High High
opiate 4 91.60 High High
antagonist 3 91.04 High High
Kinase C 4 90.12 High High
Opioid 3 75.00 Quite High
agonist 3 50.00 Quite Low
corticosteroid 2 45.20 Quite Low
Central nervous system 22 20.96 Low Low
chemokine 4 11.04 Low Low
Disease Link Frequency Relevance Heat
Communicable Diseases 3 99.88 Very High Very High Very High
Targeted Disruption 20 96.72 Very High Very High Very High
Sprains And Strains 44 95.04 Very High Very High Very High
Pneumonia 39 94.76 High High
Vibrio Infection 1 88.44 High High
Multiple Sclerosis 57 84.40 Quite High
Death 10 77.12 Quite High
Bacterial Meningitis 6 76.80 Quite High
Apoptosis 5 76.68 Quite High
Infection 59 75.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of assays of IL-2 and IFN-?
Regulation (results) of Localization (assays) of IL-2
1) Confidence 0.30 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1084244 Disease Relevance 0 Pain Relevance 0
The effect of deltorphin and DAME on secretion of the T cell growth factor, IL-2, was determined by ELISA analysis of supernatants obtained from CD4+ T cells after 48-hr culture.
Regulation (effect) of Localization (secretion) of IL-2 in T cells
2) Confidence 0.26 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791081 Disease Relevance 0 Pain Relevance 0.18
These results suggest that vitamin D3's ability to decrease the number of Treg cells may be the result of its inhibitory effect on the amount of IL-2 secreted by CD4+ T cells.


Regulation (effect) of Localization (secreted) of IL-2 in T cells
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.08 Pain Relevance 0
The plates were incubated at 37°C in 5% CO2 and 95% air, and the supernatants were collected after 48 h (in the case of IL-2 and IFN-?)
Regulation (collected) of Localization (case) of IL-2
4) Confidence 0.14 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.19 Pain Relevance 0.17
, IL-2 and IL-4 secretion (spleen>>CLN) and IL-5 expression (spleen?
Regulation (spleen) of Localization (secretion) of IL-2 in spleen
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.54 Pain Relevance 0.06
In contrast, morphine treatment had no effect on PMA/calcium ionophore (A23187)-induced increase in IL-2 secretion, suggesting a selective inhibition of IL-2R expression.
Neg (no) Regulation (effect) of Localization (secretion) of IL-2 associated with morphine
6) Confidence 0.12 Published 1993 Journal Life Sci. Section Abstract Doc Link 8098501 Disease Relevance 0 Pain Relevance 1.27
However, juglone had no significant effect on the abundance of IL-2, IFN-?
Neg (no) Regulation (effect) of Localization (abundance) of IL-2
7) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.30 Pain Relevance 0.14
has often been used as a single readout for Th1 responses, but recent studies of other infectious diseases have emphasized the importance of polyfunctional T cells co-producing IL-2, IFN-?
Regulation (emphasized) of Localization (importance) of IL-2 in T cells associated with communicable diseases
8) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.56 Pain Relevance 0
Under Th17 polarizing conditions, neutralization of IL-2 or IFN-?
Regulation (Under) of Localization (neutralization) of IL-2
9) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

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