INT5279

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Context Info
Confidence 0.81
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.80
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ggt1) aging (Ggt1) transferase activity, transferring acyl groups (Ggt1)
Anatomy Link Frequency
liver 2
blood 1
proximal 1
bile 1
Ggt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 20 99.92 Very High Very High Very High
Paracetamol 6 99.74 Very High Very High Very High
withdrawal 8 98.84 Very High Very High Very High
alcohol 1 97.94 Very High Very High Very High
analgesia 1 97.62 Very High Very High Very High
diclofenac 8 96.20 Very High Very High Very High
anesthesia 4 92.16 High High
ketamine 1 80.64 Quite High
cINOD 6 75.00 Quite High
Angina 1 60.24 Quite High
Disease Link Frequency Relevance Heat
Nephrotoxicity 5 99.40 Very High Very High Very High
Toxicity 4 99.30 Very High Very High Very High
Renal Disease 5 97.40 Very High Very High Very High
Opiate Addiction 2 96.38 Very High Very High Very High
Disease 2 95.88 Very High Very High Very High
Cv Unclassified Under Development 1 94.56 High High
Obesity 4 94.24 High High
Pre-eclampsia 3 90.40 High High
Hypoxia 3 83.96 Quite High
Pyelonephritis 3 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Excretion of urinary gamma-glutamyl transferase (GGT) was studied in rats following p.o. application of high doses (10 mg/kg/day) of indomethacin, diclofenac sodium or piroxicam for 28 days.
Localization (Excretion) of gamma-glutamyl transferase associated with diclofenac
1) Confidence 0.81 Published 1997 Journal Arch. Immunol. Ther. Exp. (Warsz.) Section Abstract Doc Link 9090444 Disease Relevance 0.15 Pain Relevance 0.15
Excretion of urinary gamma-glutamyl transferase (GGT) was studied in rats following p.o. application of high doses (10 mg/kg/day) of indomethacin, diclofenac sodium or piroxicam for 28 days.
Localization (Excretion) of GGT associated with diclofenac
2) Confidence 0.78 Published 1997 Journal Arch. Immunol. Ther. Exp. (Warsz.) Section Abstract Doc Link 9090444 Disease Relevance 0.15 Pain Relevance 0.15
The impact of adaptation to the withdrawal syndrome was that it prevented the development of withdrawal analgesia, higher alcohol consumption after its withdrawal, withdrawal hepatic activation of lipid oxidation products and blood release of the hepatic specific enzymes fructose monophosphataldolase and gamma-glutamyl transpeptidase.
Localization (release) of gamma-glutamyl transpeptidase in blood associated with withdrawal, alcohol and analgesia
3) Confidence 0.77 Published 1992 Journal Kardiologiia Section Abstract Doc Link 1297890 Disease Relevance 0.52 Pain Relevance 0.51
In order to determine the relationship between the nephrotoxicity of acetaminophen and urinary gamma-glutamyl transferase (GGT) excretion, a single dose of 900 mg/kg acetaminophen (APAP) was administered to rats intraperitoneally.
Localization (excretion) of gamma-glutamyl transferase associated with nephrotoxicity and paracetamol
4) Confidence 0.73 Published 1997 Journal Drug Metabol Drug Interact Section Abstract Doc Link 9713578 Disease Relevance 0.17 Pain Relevance 0.53
Our objectives were to characterize the acute toxicity of DAPM in liver, particularly on secretion of biliary constituents and on biliary epithelial cell gamma-glutamyl transpeptidase (GGT) activity.
Localization (secretion) of gamma-glutamyl transpeptidase in liver associated with toxicity
5) Confidence 0.62 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1440618 Disease Relevance 0.31 Pain Relevance 0.24
The ontogeny of hepatic synthesis and biliary secretion of glutathione was characterized and correlated with hepatic gamma glutamyl transpeptidase, bile flow rate, biliary bile acids and amino acids in Sprague-Dawley rats at 18 days of gestation and postnatally at ages 7, 14, 21, 28 and 54 days.
Localization (secretion) of gamma glutamyl transpeptidase in bile associated with bile
6) Confidence 0.62 Published 1994 Journal Hepatology Section Abstract Doc Link 7910575 Disease Relevance 0 Pain Relevance 0.35
Serum gamma-glutamyltranspeptidase (GGTP) and alpha-amylase clearance were determined in a total group of 90 patients of whom 60 with renal diseases and 30 with extrarenal diseases.
Localization (clearance) of GGTP associated with renal disease and disease
7) Confidence 0.19 Published 1985 Journal Med Interne Section Abstract Doc Link 2864737 Disease Relevance 0.99 Pain Relevance 0.06
Urinary excretion of the low molecular weight protein beta 2-microglobulin and tubular enzymes--alanine aminopeptidase (AAP), gamma-glutamyl transpeptidase (gamma-GT) and alkaline phosphatase (AP)--are very sensitive parameters for proximal tubular lesions.
Localization (excretion) of gamma-glutamyl transpeptidase in proximal
8) Confidence 0.04 Published 1981 Journal Contrib Nephrol Section Abstract Doc Link 6164517 Disease Relevance 0.33 Pain Relevance 0
METHODS: We prospectively evaluated the levels of the serum concentration of liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), and total bilirubin (TBil), in 42 morbidly obese and 40 non obese patients who were scheduled for elective abdominal surgery under sevoflurane anesthesia at the Jordan University Hospital, Amman, Jordan.
Localization (aspartate aminotransferase) of gamma glutamyl transferase in liver
9) Confidence 0.04 Published 2009 Journal Middle East J Anesthesiol Section Body Doc Link 19583067 Disease Relevance 0.19 Pain Relevance 0

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