INT528

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Context Info
Confidence 0.78
First Reported 1970
Last Reported 2010
Negated 12
Speculated 14
Reported most in Abstract
Documents 693
Total Number 707
Disease Relevance 217.18
Pain Relevance 192.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 103
pituitary 60
lactotrophs 23
blood 15
thyroid 13
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1097 100.00 Very High Very High Very High
Serotonin 370 100.00 Very High Very High Very High
depression 293 100.00 Very High Very High Very High
anesthesia 241 100.00 Very High Very High Very High
Enkephalin 200 100.00 Very High Very High Very High
headache 194 100.00 Very High Very High Very High
Pain 166 100.00 Very High Very High Very High
noradrenaline 62 100.00 Very High Very High Very High
tetrodotoxin 43 100.00 Very High Very High Very High
Hippocampus 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 3187 100.00 Very High Very High Very High
Cancer 1910 100.00 Very High Very High Very High
Pituitary Cancer 832 100.00 Very High Very High Very High
Prolactinoma 518 100.00 Very High Very High Very High
Galactorrhea 460 100.00 Very High Very High Very High
Depression 424 100.00 Very High Very High Very High
Adenoma 371 100.00 Very High Very High Very High
Reprotox - General 2 321 100.00 Very High Very High Very High
Headache 207 100.00 Very High Very High Very High
Pain 143 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single injection of morphine also resulted 4 hr later in an attenuation of the PRL response to a second injection of morphine (7.5 mg/kg); however, the increase in serum PRL concentration produced by alpha-methyltyrosine (250 mg/kg) was unaltered by prior morphine administration.
Gene_expression (produced) of PRL associated with morphine
1) Confidence 0.78 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3950867 Disease Relevance 0.17 Pain Relevance 1.34
Serum PRL levels before, during, and after major gynecologic surgery were measured in 20 women randomly assigned to one of four pretreatment regimens: (1) dexamethasone, (2) promethazine, (3) both agents, and (4) neither agent.
Gene_expression (levels) of PRL associated with dexamethasone
2) Confidence 0.78 Published 1978 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 707580 Disease Relevance 0.09 Pain Relevance 0.16
However, morphine+naloxone administration increased mean serum prolactin levels and the absolute amplitudes of prolactin pulses in pituitary-grafted rats.
Gene_expression (levels) of prolactin in pituitary associated with narcan and morphine
3) Confidence 0.78 Published 1994 Journal Vet Hum Toxicol Section Abstract Doc Link 7900271 Disease Relevance 0.07 Pain Relevance 0.73
Training the animals to be handled prevented the increase in plasma prolactin levels produced by decapitation; training had no influence on the decapitation-induced rises in plasma CA concentrations.
Gene_expression (produced) of prolactin in plasma associated with catecholamine and decapitation
4) Confidence 0.78 Published 1981 Journal J Pharmacol Methods Section Abstract Doc Link 7311568 Disease Relevance 0.20 Pain Relevance 0.36
It is known that prolactin (PRL) is produced within the brain and numerous central actions of the hormone have been reported.
Gene_expression (produced) of PRL in brain
5) Confidence 0.78 Published 2001 Journal Physiol. Behav. Section Abstract Doc Link 11564459 Disease Relevance 0 Pain Relevance 0.08
It is known that prolactin (PRL) is produced within the brain and numerous central actions of the hormone have been reported.
Gene_expression (produced) of prolactin in brain
6) Confidence 0.78 Published 2001 Journal Physiol. Behav. Section Abstract Doc Link 11564459 Disease Relevance 0 Pain Relevance 0.08
These experiments demonstrated a dramatic (40-fold) upregulation of prolactin (PRL) expression in TG by 17-beta-estradiol (E2).
Gene_expression (expression) of prolactin
7) Confidence 0.78 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16885226 Disease Relevance 0.18 Pain Relevance 0.17
PRL expression was restricted to TG neurons and was highly overlapped with transient potential receptor vanilloid type 1 (TRPV1) (approximately 90%) in TG.
Gene_expression (expression) of PRL in neurons
8) Confidence 0.78 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16885226 Disease Relevance 0.17 Pain Relevance 0.17
These experiments demonstrated a dramatic (40-fold) upregulation of prolactin (PRL) expression in TG by 17-beta-estradiol (E2).
Gene_expression (expression) of PRL
9) Confidence 0.78 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16885226 Disease Relevance 0.18 Pain Relevance 0.17
The difference in the stimulation-evoked release occurred in the presence of similar circulating serum PRL levels in the two groups as a result of the 3-day E2 treatment.
Gene_expression (levels) of PRL
10) Confidence 0.78 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3796794 Disease Relevance 0 Pain Relevance 0.19
In male rats treated with FEN, IDZ and CLO, a significant decrease of plasma PRL was produced, but YOH further enhanced PRL secretion.
Gene_expression (produced) of PRL in plasma associated with clonidine
11) Confidence 0.78 Published 1991 Journal Horm. Metab. Res. Section Abstract Doc Link 1678730 Disease Relevance 0.32 Pain Relevance 0.50
Serum prolactin levels of rats under continuous estrogen stimulation and 2 Br-alpha-ergocryptine (CB-154) injection.
Gene_expression (levels) of prolactin
12) Confidence 0.78 Published 1975 Journal Proc. Soc. Exp. Biol. Med. Section Title Doc Link 1153405 Disease Relevance 0 Pain Relevance 0.07
It was suggested that, while CB-154 prevents the release of prolactin, estrogen stimulates prolactin synthesis despite the block of its release.
Gene_expression (synthesis) of prolactin
13) Confidence 0.78 Published 1975 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 1153405 Disease Relevance 0 Pain Relevance 0.10
There is an age-related increase in the cell population engaged in prolactin secretion, as well as an increase in the synthesis of prolactin and of the amount of prolactin secreted from individual lactotropes. 3.
Gene_expression (synthesis) of prolactin in lactotropes
14) Confidence 0.78 Published 1992 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 1571952 Disease Relevance 0.07 Pain Relevance 0.12
The effects of naloxone infusion on plasma prolactin (PRL) levels and on the PRL response to mechanical breast emptying were investigated in a group of puerperal women, Five, 10, and 20 mg naloxone administered to women on days 2 to 3 of the puerperium produced no significant change in serum PRL.
Gene_expression (levels) of PRL in plasma associated with narcan
15) Confidence 0.78 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6685061 Disease Relevance 0 Pain Relevance 0.24
To investigate this hypothesis, we measured luteinizing hormone, follicle-stimulating hormone, and PRL levels in eumenorrheic and amenorrheic athletes during thyrotropin-releasing hormone and gonadotropin-releasing hormone tests at baseline, after naloxone infusions, after exercise to exhaustion, and after similar exercise during naloxone infusions.
Gene_expression (levels) of PRL in follicle associated with narcan
16) Confidence 0.78 Published 1991 Journal Fertil. Steril. Section Abstract Doc Link 1900478 Disease Relevance 0.17 Pain Relevance 0.36
Second, serum PRL levels during the estrous cycle describe a daily rhythm of PRL release with maximum serum concentrations each day occurring in the afternoon and the highest of these occurring on proestrus (day 4 of cycle).
Gene_expression (levels) of PRL
17) Confidence 0.78 Published 1984 Journal Am. J. Physiol. Section Abstract Doc Link 6540053 Disease Relevance 0 Pain Relevance 0.10
The effects of naloxone infusion on plasma prolactin (PRL) levels and on the PRL response to mechanical breast emptying were investigated in a group of puerperal women, Five, 10, and 20 mg naloxone administered to women on days 2 to 3 of the puerperium produced no significant change in serum PRL.
Gene_expression (levels) of prolactin in plasma associated with narcan
18) Confidence 0.78 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6685061 Disease Relevance 0 Pain Relevance 0.24
Mifepristone increased prolactin mRNA and protein expression.
Gene_expression (expression) of prolactin
19) Confidence 0.77 Published 2009 Journal Neuroendocrinology Section Body Doc Link 18832805 Disease Relevance 0 Pain Relevance 0
The present study explores ultrastructural changes in lactotropes after mifepristone and naloxone administration, correlating them with the expression of pituitary prolactin.
Gene_expression (expression) of prolactin in pituitary associated with narcan
20) Confidence 0.77 Published 2009 Journal Neuroendocrinology Section Abstract Doc Link 18832805 Disease Relevance 0 Pain Relevance 0.27

General Comments

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