INT52800

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 142
Total Number 147
Disease Relevance 92.27
Pain Relevance 55.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
macrophages 17
liver 8
spinal cord 8
peritoneal macrophages 8
blood 8
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 394 100.00 Very High Very High Very High
cytokine 310 100.00 Very High Very High Very High
Glutamate 142 100.00 Very High Very High Very High
Inflammatory mediators 110 100.00 Very High Very High Very High
allodynia 82 100.00 Very High Very High Very High
Analgesic 64 100.00 Very High Very High Very High
Spinal cord 49 100.00 Very High Very High Very High
narcan 25 100.00 Very High Very High Very High
ketamine 40 99.98 Very High Very High Very High
Clonidine 22 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 526 100.00 Very High Very High Very High
Neuropathic Pain 214 100.00 Very High Very High Very High
Cancer 212 100.00 Very High Very High Very High
Necrosis 150 100.00 Very High Very High Very High
Pancreatitis 137 100.00 Very High Very High Very High
Diabetes Mellitus 76 100.00 Very High Very High Very High
Ulcers 17 100.00 Very High Very High Very High
Acute Necrotizing Pancreatitis 8 100.00 Very High Very High Very High
Sepsis 46 99.98 Very High Very High Very High
Sprains And Strains 13 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumor necrosis factor-alpha (TNFalpha) production, on the other hand, was decreased by 50%.
Negative_regulation (decreased) of Gene_expression (production) of Tumor necrosis factor-alpha associated with necrosis and cancer
1) Confidence 0.59 Published 2001 Journal Shock Section Abstract Doc Link 11336202 Disease Relevance 0.51 Pain Relevance 0.12
In conclusion, mild hemorrhagic shock produced increases in superoxide and PGE2 production, and decreases in TNFalpha production by Kupffer cells, changes that may be appropriate to defend against the infectious challenges that often follows trauma and hemorrhage.
Negative_regulation (decreases) of Gene_expression (production) of TNFalpha in PGE2 associated with injury, cva and hemorrhagic shock
2) Confidence 0.59 Published 2001 Journal Shock Section Abstract Doc Link 11336202 Disease Relevance 0.66 Pain Relevance 0.12
Impairment of TNF-alpha expression and secretion in primary rat liver cell cultures by acetaminophen treatment.
Negative_regulation (Impairment) of Gene_expression (expression) of TNF-alpha in liver associated with paracetamol
3) Confidence 0.59 Published 1999 Journal Toxicology Section Title Doc Link 10378475 Disease Relevance 0.29 Pain Relevance 0.43
The results suggest that inhibition of TNF-alpha expression and release in the liver is a consequence of acetaminophen exposure.
Negative_regulation (inhibition) of Gene_expression (expression) of TNF-alpha in liver associated with paracetamol
4) Confidence 0.59 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.19 Pain Relevance 0.52
Pretreatment with a proton pump inhibitor, omeprazole, produced only marginal (6-8%) reduction in the extent of mucosal damage caused by indomethacin, whereas the mucosal expression of TNF-alpha decreased by 15% and the apoptotic DNA fragmentation by 10-13%.
Negative_regulation (decreased) of Gene_expression (expression) of TNF-alpha
5) Confidence 0.59 Published 1997 Journal Scand. J. Gastroenterol. Section Body Doc Link 9246701 Disease Relevance 0.12 Pain Relevance 0
Three groups of rats were studied: vehicle controls (n=6); positive controls for infarct size reduction (ischemic preconditioning; n=6); and a group treated with the selective inhibitor of PDE-IV and TNF-alpha production, rolipram (1 mg/kg i.v. 10-min prereperfusion + 1 microg/kg per minute through 1-hr reperfusion, n=6). 4.
Negative_regulation (inhibitor) of Gene_expression (production) of TNF-alpha
6) Confidence 0.59 Published 1999 Journal Gen. Pharmacol. Section Abstract Doc Link 9888252 Disease Relevance 0.65 Pain Relevance 0.04
However, the prevention of NO overproduction by dantrolene, but not by nifedipine, was associated with an inhibition of TNF-alpha production elicited by LPS.
Negative_regulation (inhibition) of Gene_expression (production) of TNF-alpha
7) Confidence 0.59 Published 1999 Journal Chin J Physiol Section Abstract Doc Link 10707896 Disease Relevance 0.36 Pain Relevance 0
Our results suggest that glucocorticoid therapy for neuropathic pain may work via the reduced expression of TNFalpha in endoneurial mast cells.
Negative_regulation (reduced) of Gene_expression (expression) of TNFalpha in mast cells associated with neuropathic pain
8) Confidence 0.59 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18385539 Disease Relevance 1.59 Pain Relevance 1.10
The elevation of intracellular levels of cyclic AMP in leukocytes by phosphodiesterase 4 inhibitors is accompanied by significant inhibition of the production of TNF-alpha.
Negative_regulation (inhibition) of Gene_expression (production) of TNF-alpha in leukocytes
9) Confidence 0.58 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10884526 Disease Relevance 1.05 Pain Relevance 0.56
Intraperitoneal injection of thalidomide, an inhibitor of TNF-alpha synthesis, started at 2h before surgery, blocked mechanical allodynia and thermal hyperalgesia.
Negative_regulation (inhibitor) of Gene_expression (synthesis) of TNF-alpha associated with allodynia and thermal hyperalgesia
10) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16675114 Disease Relevance 1.20 Pain Relevance 0.95
The expression of TNF-alpha, determined by immunohistochemical staining, in synovial tissues obtained from articular joints injected with zymosan was also inhibited by thalidomide pretreatment.
Negative_regulation (inhibited) of Gene_expression (expression) of TNF-alpha in joints
11) Confidence 0.57 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16597438 Disease Relevance 0.69 Pain Relevance 0.22
This may be because salvia miltiorrhizae can effectively inhibit the release of endotoxin and thereby reduce the production of other inflammatory mediators such as TNF-?
Negative_regulation (reduce) of Gene_expression (production) of TNF associated with inflammatory mediators
12) Confidence 0.57 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.40 Pain Relevance 0.27
We had previously shown that tropisetron potently inhibits lipopolysaccharide-mediated production of TNF-?
Negative_regulation (inhibits) of Gene_expression (production) of TNF
13) Confidence 0.57 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2259310 Disease Relevance 0.33 Pain Relevance 0.46
CO2 insufflation was associated with a consistent fall in intraperitoneal pH and a significant reduction in TNFalpha production.
Negative_regulation (reduction) of Gene_expression (production) of TNFalpha
14) Confidence 0.57 Published 2000 Journal World J Surg Section Abstract Doc Link 11071467 Disease Relevance 0.67 Pain Relevance 0.08
The effect was not altered by thalidomide, a known inhibitor of tumor necrosis factor-alfa (TNF-alfa) synthesis.
Negative_regulation (inhibitor) of Gene_expression (synthesis) of TNF associated with necrosis and cancer
15) Confidence 0.57 Published 1997 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9401722 Disease Relevance 0.28 Pain Relevance 0.42
administration was accompanied by decreased expression of TNF-?
Negative_regulation (decreased) of Gene_expression (expression) of TNF
16) Confidence 0.57 Published 2010 Journal Crit Care Section Body Doc Link PMC2945141 Disease Relevance 1.31 Pain Relevance 0.62
In addition, production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and vascular endothelial growth factor (VEGF) production induced by SCF was significantly inhibited by treatment with SC-236.
Negative_regulation (inhibited) of Gene_expression (production) of TNF associated with necrosis and cancer
17) Confidence 0.57 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17320132 Disease Relevance 0.90 Pain Relevance 0.43
Sympathectomy reduces mechanical allodynia, tumor necrosis factor-alpha expression, and dorsal root ganglion apoptosis following nerve root crush injury.
Negative_regulation (reduces) of Gene_expression (expression) of tumor necrosis factor-alpha in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, necrosis, allodynia, cancer, injury and apoptosis
18) Confidence 0.56 Published 2008 Journal Spine Section Title Doc Link 18469688 Disease Relevance 0.60 Pain Relevance 0.29
Thalidomide was also found to be effective in animal models by inhibiting TNF-alpha production [10-13].
Negative_regulation (inhibiting) of Gene_expression (production) of TNF-alpha
19) Confidence 0.56 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935978 Disease Relevance 0.76 Pain Relevance 0.46
Treatment with CDP-choline decreased tumor necrosis factor-alpha production in the rat paw tissue after carrageenan.
Negative_regulation (decreased) of Gene_expression (production) of tumor necrosis factor-alpha in paw
20) Confidence 0.55 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19372354 Disease Relevance 0 Pain Relevance 0

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