INT52801

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Context Info
Confidence 0.62
First Reported 1995
Last Reported 2010
Negated 9
Speculated 15
Reported most in Abstract
Documents 55
Total Number 71
Disease Relevance 48.74
Pain Relevance 26.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
brain 8
TMJ 8
macrophage 6
alveolar macrophages 6
spinal 6
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 250 100.00 Very High Very High Very High
Inflammation 184 100.00 Very High Very High Very High
allodynia 33 100.00 Very High Very High Very High
tolerance 27 100.00 Very High Very High Very High
chemokine 21 100.00 Very High Very High Very High
Hyperalgesia 20 100.00 Very High Very High Very High
Spinal cord 18 100.00 Very High Very High Very High
Paracetamol 17 100.00 Very High Very High Very High
Inflammatory mediators 17 100.00 Very High Very High Very High
ketamine 16 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 216 100.00 Very High Very High Very High
Cancer 165 100.00 Very High Very High Very High
Neuropathic Pain 107 100.00 Very High Very High Very High
Necrosis 89 100.00 Very High Very High Very High
Obesity 60 100.00 Very High Very High Very High
Brain Injury 59 100.00 Very High Very High Very High
Hyperalgesia 42 100.00 Very High Very High Very High
Impaired Glucose Tolerance 27 100.00 Very High Very High Very High
Sprains And Strains 11 99.96 Very High Very High Very High
Peptic Ulcer 10 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, bismuth had no effect on the viability on testicular macrophages at 50 microM up to 8 h, therefore, we studied the secretion of tumor necrosis factor alpha (TNF-alpha) after 4 h of exposure to 50 microM bismuth and found no influence on the production of TNF-alpha.
Neg (no) Regulation (influence) of Gene_expression (production) of TNF-alpha in macrophages associated with necrosis and cancer
1) Confidence 0.62 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15856528 Disease Relevance 0.29 Pain Relevance 0
In sham or naive animals, no consistent changes in expression of TNF-alpha mRNA were observed in any of the six brain areas at any times (less than 5%).
Neg (no) Regulation (changes) of Gene_expression (expression) of TNF-alpha mRNA in brain
2) Confidence 0.62 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8965649 Disease Relevance 1.02 Pain Relevance 0.37
Moreover, the effects of NE and yohimbine on TNF-alpha production was further examined using an isolated perfused liver preparation.
Regulation (effects) of Gene_expression (production) of TNF-alpha in liver
3) Confidence 0.62 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.31 Pain Relevance 0.29
OBJECTIVE: To observe the effect of electroacupuncture (EA) on the expression of spinal glial fibrillary acidic protein (GFAP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in chronic constriction injury (CCI) rats.
Regulation (effect) of Gene_expression (expression) of tumor necrosis factor-alpha in spinal associated with necrosis, cancer, eae, injury and electroacupuncture
4) Confidence 0.61 Published 2010 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 20458900 Disease Relevance 0.52 Pain Relevance 0.21
Thus, we aimed to assess the effects of a rich fish oil dietetic intervention on glucose tolerance, serum insulin and adiponectin, and adipose tissue gene expression of adiponectin and TNF-?
Regulation (effects) of Gene_expression (expression) of TNF in adipose tissue associated with obesity, tolerance and impaired glucose tolerance
5) Confidence 0.60 Published 2008 Journal Lipids Health Dis Section Abstract Doc Link PMC2613381 Disease Relevance 0.88 Pain Relevance 0.08
This investigation examined if the expression of TNF-alpha and its receptors was altered in TMJ tissues during inflammation.
Regulation (altered) of Gene_expression (expression) of TNF-alpha associated with inflammation
6) Confidence 0.56 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 14514761 Disease Relevance 0.52 Pain Relevance 0.23
TNFalpha is known to increase NO production, but the effect of NO on the production of TNFalpha has not yet been fully elucidated.
Regulation (effect) of Gene_expression (production) of TNFalpha
7) Confidence 0.55 Published 2001 Journal Shock Section Abstract Doc Link 11303732 Disease Relevance 0.52 Pain Relevance 0.21
Kainic acid up-regulated the expression of the inflammatory cytokines IL-1beta and TNF-alpha, the neurotrophic factor IGF-1, and the transcription factor NF-kappaB.
Regulation (regulated) of Gene_expression (expression) of TNF-alpha associated with inflammation and cytokine
8) Confidence 0.47 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.70 Pain Relevance 0.53
In the present study, we demonstrate the effects of SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea), a novel orally active inhibitor of TNF-alpha production, in animal models, and its mechanism of action on TNF-alpha production.
Regulation (action) of Gene_expression (production) of TNF-alpha
9) Confidence 0.46 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18508045 Disease Relevance 0.34 Pain Relevance 0.30
We used primary rat hepatocyte and Kupffer cell cultures to test the direct action of subtoxic and toxic concentrations of acetaminophen on TNF-alpha expression and release.
Regulation (action) of Gene_expression (expression) of TNF-alpha in Kupffer cell associated with paracetamol
10) Confidence 0.45 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.25 Pain Relevance 0.47
These results, taken together, suggest that gut-derived NE upregulates TNF-alpha production in Kupffer cells through an alpha(2)-adrenergic pathway, which appears to be responsible at least in part for the increased levels of circulating TNF-alpha observed during early sepsis as well as other pathophysiologic conditions such as trauma, hemorrhagic shock, or gut ischemia/reperfusion.
Regulation (responsible) of Gene_expression (levels) of TNF-alpha in gut associated with ischemia, injury, hemorrhagic shock and sepsis
11) Confidence 0.45 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.39 Pain Relevance 0.24
These results, taken together, suggest that gut-derived NE upregulates TNF-alpha production in Kupffer cells through an alpha(2)-adrenergic pathway, which appears to be responsible at least in part for the increased levels of circulating TNF-alpha observed during early sepsis as well as other pathophysiologic conditions such as trauma, hemorrhagic shock, or gut ischemia/reperfusion.
Regulation (responsible) of Gene_expression (production) of TNF-alpha in gut associated with ischemia, injury, hemorrhagic shock and sepsis
12) Confidence 0.45 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.38 Pain Relevance 0.25
Collectively, this evidence suggests that enhanced early neuronal expression of TNF alpha after TBI contributes to subsequent neurological dysfunction.
Regulation (contributes) of Gene_expression (expression) of TNF alpha in neuronal associated with anesthesia and brain injury
13) Confidence 0.45 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10229121 Disease Relevance 1.10 Pain Relevance 0.26
In this study, we investigated the effects of dantrolene and nifedipine, two agents of reducing intracellular calcium levels, on bacterial endotoxin (lipopolysaccharide, LPS; 10 mg/kg i.v.)
Spec (investigated) Regulation (effects) of Gene_expression (production) of tumor necrosis factor-alpha
14) Confidence 0.45 Published 1999 Journal Chin J Physiol Section Abstract Doc Link 10707896 Disease Relevance 0.37 Pain Relevance 0
In this study, we investigated the effects of dantrolene and nifedipine, two agents of reducing intracellular calcium levels, on bacterial endotoxin (lipopolysaccharide, LPS; 10 mg/kg i.v.)
Spec (investigated) Regulation (effects) of Gene_expression (production) of TNF-alpha
15) Confidence 0.45 Published 1999 Journal Chin J Physiol Section Abstract Doc Link 10707896 Disease Relevance 0.37 Pain Relevance 0
[Effect of electroacupuncture on the expression of spinal glial fibrillary acidic protein, tumor necrosis factor-alpha and interleukin-1beta in chronic neuropathic pain rats].
Regulation ([Effect) of Gene_expression (expression) of tumor necrosis factor-alpha in spinal associated with necrosis, neuralgia, cancer, neuropathic pain and electroacupuncture
16) Confidence 0.45 Published 2010 Journal Zhen Ci Yan Jiu Section Title Doc Link 20458900 Disease Relevance 0.30 Pain Relevance 0.54
OBJECTIVE: To observe the effect of electroacupuncture (EA) on the expression of spinal glial fibrillary acidic protein (GFAP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in chronic constriction injury (CCI) rats.
Regulation (effect) of Gene_expression (expression) of TNF-alpha in spinal associated with necrosis, cancer, eae, injury and electroacupuncture
17) Confidence 0.45 Published 2010 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 20458900 Disease Relevance 0.52 Pain Relevance 0.21
There has been much interest in strategies which modulate tumour necrosis factor-alpha (TNF-alpha) levels and/or function in rheumatoid arthritis.
Regulation (modulate) of Gene_expression (levels) of TNF-alpha associated with necrosis, cancer and rheumatoid arthritis
18) Confidence 0.45 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10884526 Disease Relevance 0.84 Pain Relevance 0.44
Oral treatment with Catuama was not, however, effective in altering the production of the pro-inflammatory mediators IL-1beta, TNFalpha, PGE(2) or LTB(4) following i.pl. administration of LPS in the rat paw.
Regulation (altering) of Gene_expression (production) of TNFalpha in paw associated with inflammatory mediators
19) Confidence 0.45 Published 2008 Journal Phytomedicine Section Abstract Doc Link 17482443 Disease Relevance 1.27 Pain Relevance 1.05
Because acetylcholine's interaction with nicotine receptors on tissue macrophages during vagus nerve stimulation has been implicated in the modulation of LPS-stimulated tumor necrosis factor alpha (TNF-alpha) production, we hypothesized that the mechanism of anesthetic immunoprotection is mediated through the vagus nerve.
Regulation (modulation) of Gene_expression (production) of TNF-alpha in vagus nerve associated with necrosis, cancer, nicotine and vagus nerve
20) Confidence 0.45 Published 2005 Journal Surgery Section Abstract Doc Link 16269307 Disease Relevance 0.36 Pain Relevance 0.35

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