INT52806

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.95

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nucleoplasm (RYBP) small molecule metabolic process (CYP2E1) oxidoreductase activity (CYP2E1)
endoplasmic reticulum (CYP2E1) nucleus (RYBP) intracellular (RYBP)
CYP2E1 (Homo sapiens)
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 2 97.16 Very High Very High Very High
Hepatocellular Cancer 2 96.60 Very High Very High Very High
Necrosis 1 46.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate the ability of human CYP2E1 to activate APAP to reactive metabolites which form covalent protein adducts and cause toxicity to a hepatoma cell line.
CYP2E1 Positive_regulation (activate) of APAP associated with toxicity, paracetamol and hepatocellular cancer
1) Confidence 0.43 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791125 Disease Relevance 0.24 Pain Relevance 0.95

General Comments

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