INT52813

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Context Info
Confidence 0.62
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.16
Pain Relevance 5.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
trigeminal ganglion 4
endothelial cell 2
colon 2
neurons 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 157 100.00 Very High Very High Very High
trigeminal ganglion 32 100.00 Very High Very High Very High
Neuropeptide 13 100.00 Very High Very High Very High
Clonidine 9 100.00 Very High Very High Very High
Somatostatin 5 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
vanilloid receptor subtype 1 8 99.74 Very High Very High Very High
Inflammation 6 99.36 Very High Very High Very High
qutenza 14 99.26 Very High Very High Very High
Pain 52 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 32 100.00 Very High Very High Very High
Congenital Anomalies 4 99.92 Very High Very High Very High
Neurogenic Inflammation 2 99.80 Very High Very High Very High
Natriuresis 1 99.72 Very High Very High Very High
Gallstones 5 99.36 Very High Very High Very High
Pain 49 99.00 Very High Very High Very High
Inflammatory Bowel Disease 7 98.16 Very High Very High Very High
Stress 3 94.16 High High
Galactorrhea 124 91.92 High High
INFLAMMATION 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied the release of CGRP in normal human gallbladders and in those containing gallstones to test the hypothesis that abnormalities of regulation of CGRP release participate in gallstone formation.
Regulation (regulation) of Localization (release) of CGRP associated with congenital anomalies, gallstones and calcitonin gene-related peptide
1) Confidence 0.62 Published 1995 Journal J. Surg. Res. Section Abstract Doc Link 7791341 Disease Relevance 0.53 Pain Relevance 0.33
Around 10% of the VR1 receptor-ir is expressed on neurons that contain CGRP-ir (ten among 74) in the human TG, indicating that capsaicin may act through the VR1 receptor to modulate the release of CGRP and in turn to modulate pain.
Regulation (modulate) of Localization (release) of CGRP in neurons associated with pain, vanilloid receptor subtype 1, qutenza, trigeminal ganglion and calcitonin gene-related peptide
2) Confidence 0.51 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12270633 Disease Relevance 0.68 Pain Relevance 1.94
We conclude that 1) patients with UC show an increased mucosal expression of mRNA for ghrelin in the colonic mucosa which could trigger protective response in inflamed colon; and 2) exogenous ghrelin accelerates healing of colonic lesions in animal model of ulcerative colitis via increased release of NO and PGE(2) due to an increase in iNOS and COX-2 expression and stimulation of sensory neuropeptides such as CGRP released from sensory afferent endings.
Regulation (stimulation) of Localization (released) of CGRP in colon associated with inflammatory bowel disease and neuropeptide
3) Confidence 0.44 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 19617644 Disease Relevance 0.51 Pain Relevance 0.17
Familiar hemiplegic migraine patients seem to be less sensitive to GTN and CGRP provocation compared with common types of migraine.
Regulation (sensitive) of Localization (provocation) of CGRP
4) Confidence 0.44 Published 2010 Journal Curr. Opin. Neurol. Section Body Doc Link 20173638 Disease Relevance 0.07 Pain Relevance 0
It was proposed that elevated RAMP1 expression could sensitize the trigeminal ganglion of individuals to CGRP actions such as CGRP release and neurogenic inflammation [47].
Regulation (sensitize) of Localization (release) of CGRP in trigeminal ganglion associated with ganglion cysts, inflammation, trigeminal ganglion, neurogenic inflammation and calcitonin gene-related peptide
5) Confidence 0.42 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.51 Pain Relevance 0.99
It was proposed that elevated RAMP1 expression could sensitize the trigeminal ganglion of individuals to CGRP actions such as CGRP release and neurogenic inflammation [47].
Regulation (sensitize) of Localization (release) of CGRP in trigeminal ganglion associated with ganglion cysts, inflammation, trigeminal ganglion, neurogenic inflammation and calcitonin gene-related peptide
6) Confidence 0.42 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.51 Pain Relevance 0.99
The effect of clonidine on endothelial cell-derived CGRP synthesis and secretion was attenuated in the presence of yohimbine.
Regulation (effect) of Localization (secretion) of CGRP in endothelial cell associated with calcitonin gene-related peptide and clonidine
7) Confidence 0.27 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.21
A number of other neurotrasmitters and neuropeptides can also modulate prolactin secretion, among which galanin, endothelin, TGFbeta1, angiotensin, somatostatin, substance P, neurotensin, calcitonin, EGF, natriuretic atrial peptide, bombesin, colecistokinine, acetylcholine, vasopressin (Figure 1).
Regulation (modulate) of Localization (secretion) of calcitonin associated with natriuresis, somatostatin, neuropeptide and substance p
8) Confidence 0.21 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.34 Pain Relevance 0.27

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