INT52814

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.69
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
muscle 1
pituitary 1
amygdala 1
hippocampus 1
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 24 100.00 Very High Very High Very High
narcan 7 99.70 Very High Very High Very High
Morphine 13 99.68 Very High Very High Very High
Endogenous opioid 2 99.58 Very High Very High Very High
opiate 5 99.28 Very High Very High Very High
withdrawal 6 99.00 Very High Very High Very High
amygdala 10 98.80 Very High Very High Very High
Glutamate 132 98.60 Very High Very High Very High
sSRI 13 98.60 Very High Very High Very High
fluoxetine 8 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 237 99.98 Very High Very High Very High
Targeted Disruption 1 99.78 Very High Very High Very High
Sepsis 5 99.48 Very High Very High Very High
Recurrence 2 98.40 Very High Very High Very High
Opiate Addiction 4 97.92 Very High Very High Very High
Neurodegenerative Disease 3 97.76 Very High Very High Very High
Pressure And Volume Under Development 18 97.24 Very High Very High Very High
Shock 8 96.36 Very High Very High Very High
Congenital Anomalies 2 94.20 High High
Drug Dependence 1 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we determined whether concurrent glucocorticoid receptor (GR) blockade enhances these neurochemical responses to the SSRI fluoxetine.
Spec (whether) Negative_regulation (blockade) of glucocorticoid receptor associated with ssri and fluoxetine
1) Confidence 0.57 Published 2007 Journal Biol. Psychiatry Section Abstract Doc Link 17651703 Disease Relevance 0 Pain Relevance 0.48
Role of endogenous opioid peptides in central glucocorticoid receptor (GR)-induced decreases in circulating LH in the male rat.
Negative_regulation (decreases) of glucocorticoid receptor associated with narcan and endogenous opioid
2) Confidence 0.17 Published 1995 Journal Neuropeptides Section Title Doc Link 7791961 Disease Relevance 0.05 Pain Relevance 0.43
This is further evidenced by our experiments with ADX rats and the glucocorticoid receptor antagonist, RU486.
Negative_regulation (antagonist) of glucocorticoid receptor associated with antagonist
3) Confidence 0.13 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.86 Pain Relevance 1.02
Selective down-regulation of hippocampal glucocorticoid receptors during opiate withdrawal.
Negative_regulation (regulation) of glucocorticoid associated with narcan, opiate and withdrawal
4) Confidence 0.12 Published 2003 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 14559365 Disease Relevance 0.24 Pain Relevance 1.18
Stress induced rapid increase in the circulating levels of corticosterone in all rats (both vehicle- and drug-treated), and glutamate release increase was blocked by previous administration of selective antagonist of glucocorticoid receptor (RU 486).
Negative_regulation (antagonist) of glucocorticoid receptor associated with stress, glutamate and antagonist
5) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797327 Disease Relevance 1.26 Pain Relevance 0.58
In some experiments, the rats were treated 30 min before stress with RU 486, a selective antagonist of glucocorticoid receptor (GR), or RU 28318, a selective antagonist of MR (50 mg/kg s.c.; dissolved in dimethylsulfoxide or propylene glycol, respectively).
Negative_regulation (antagonist) of glucocorticoid receptor associated with stress and antagonist
6) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.79 Pain Relevance 0.23
Repeated morphine administration down-regulates glucocorticoid, but not mineralocorticoid, receptors in the rat hippocampus.
Negative_regulation (down-regulates) of glucocorticoid in hippocampus associated with hippocampus and morphine
7) Confidence 0.11 Published 1995 Journal Psychoneuroendocrinology Section Title Doc Link 7838904 Disease Relevance 0 Pain Relevance 0.62
Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala.
Negative_regulation (impairs) of glucocorticoid in amygdala associated with stress and amygdala
8) Confidence 0.08 Published 2008 Journal J. Neurosci. Section Title Doc Link 18495894 Disease Relevance 0.65 Pain Relevance 0.46
Using transgenic mice with impaired glucocorticoid receptor function, Barden et al (2005) concluded that the behavioral effects of agomelatine are not associated with changes in hypothalamic-pituitary-adrenal axis activity.
Negative_regulation (impaired) of glucocorticoid receptor in pituitary associated with targeted disruption
9) Confidence 0.07 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655086 Disease Relevance 1.06 Pain Relevance 0.33
Similarly, the increase in muscle proteolysis induced by Ang II or sepsis is largely eliminated by inhibiting the glucocorticoid receptor [7, 54].
Negative_regulation (inhibiting) of glucocorticoid receptor in muscle associated with sepsis
10) Confidence 0.04 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.78 Pain Relevance 0.03
In adult hamsters, basal proenkephalin (Penk) gene expression in adrenals is independent of glucocorticoids and glucocorticoid receptor blockade, by RU 486, increases striatal preproenkephalin (PPenk) mRNA levels.
Negative_regulation (blockade) of glucocorticoid receptor
11) Confidence 0.03 Published 2006 Journal Brain Res. Section Abstract Doc Link 16597437 Disease Relevance 0 Pain Relevance 0.04

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