INT52818

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 7.65
Pain Relevance 4.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
Anatomy Link Frequency
nucleus 4
spinal cord dorsal horn 2
plasma 1
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 13 100.00 Very High Very High Very High
Dopamine 12 100.00 Very High Very High Very High
agonist 86 99.96 Very High Very High Very High
dexamethasone 17 99.70 Very High Very High Very High
Spinal cord 8 98.96 Very High Very High Very High
cINOD 2 98.84 Very High Very High Very High
Catechol-O-methyltransferase 9 98.64 Very High Very High Very High
depression 29 98.62 Very High Very High Very High
Dorsal horn 8 98.48 Very High Very High Very High
Inflammation 114 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 2 Under Development 5 100.00 Very High Very High Very High
Aids-related Complex 2 99.36 Very High Very High Very High
Disease 47 99.32 Very High Very High Very High
Stress 21 99.00 Very High Very High Very High
Depression 30 98.62 Very High Very High Very High
INFLAMMATION 128 98.60 Very High Very High Very High
Asthma 15 98.56 Very High Very High Very High
Sepsis 34 98.28 Very High Very High Very High
Death 6 98.16 Very High Very High Very High
Obesity 46 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Table 2[18], there were ten candidate genes including COMT, corticotropin releasing hormone receptor 1 (CRHR1), corticotropin releasing hormone receptor 2 (CRHR2), MAOA, MAOB, NR3C1, POMC, solute carrier family 6 member 4 (SLC6A4), tyrosine hydroxylase (TH), and TPH2 genes.
Localization (releasing) of NR3C1 associated with catechol-o-methyltransferase
1) Confidence 0.69 Published 2009 Journal J Transl Med Section Body Doc Link PMC2765429 Disease Relevance 0.49 Pain Relevance 0.13
Glucocorticoids interact with a specific cytosolic glucocorticoid receptor, which undergoes conformational changes, sheds heat shock proteins and translocates to the nucleus.
Localization (translocates) of cytosolic glucocorticoid receptor in nucleus associated with cv general 2 under development
2) Confidence 0.29 Published 2004 Journal Crit Care Section Abstract Doc Link PMC522845 Disease Relevance 0.58 Pain Relevance 0.04
The immunohistochemical data indicated a pattern of colocalization between GR and EAAC1 as well as GR and NF-kappaB within the spinal cord dorsal horn.
Localization (colocalization) of GR in spinal cord dorsal horn associated with dorsal horn and spinal cord
3) Confidence 0.29 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.67 Pain Relevance 0.66
The immunohistochemical data indicated a pattern of colocalization between GR and EAAC1 as well as GR and NF-kappaB within the spinal cord dorsal horn.
Localization (colocalization) of GR in spinal cord dorsal horn associated with dorsal horn and spinal cord
4) Confidence 0.27 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.67 Pain Relevance 0.67
A possible link between possible changes of the RAAS and the HPA system in depression was further demonstrated by the significant increase in aldosterone secretion after administration of the glucocorticoid receptor agonist dexamethasone in healthy female subjects, whereas in depressed females aldosterone showed a trend to a decrease [32].
Localization (secretion) of glucocorticoid receptor associated with depression, agonist and dexamethasone
5) Confidence 0.15 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.50 Pain Relevance 0.40
In the present report, GR0mRNA and GR0 were fitted as well as other parameters in the receptor dynamics model.
Localization (fitted) of GR0
6) Confidence 0.11 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.08
The observed decline in peripheral plasma LH following intra-ARC injection of DEX suggests that local GR may be functional target sites for glucocorticoid effects on LH.
Localization (local) of GR in plasma associated with aids-related complex and dexamethasone
7) Confidence 0.11 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7791961 Disease Relevance 0.18 Pain Relevance 0.50
Long-term treatment of the cell cultures with RU 39305, a selective antagonist of glucocorticoid receptors (GR), but not with spironolactone, a selective antagonist of mineralocorticoid receptors (MR), dose-dependently decreased K+-stimulated dopamine release.
Localization (release) of GR associated with dopamine and antagonist
8) Confidence 0.09 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10383623 Disease Relevance 0 Pain Relevance 0.86
They act by binding to the glucocorticoid receptor (GR) that, upon activation, translocates to the nucleus and either stimulates or inhibits gene expression.
Localization (translocates) of glucocorticoid receptor in nucleus
9) Confidence 0.09 Published 2004 Journal Mech. Ageing Dev. Section Abstract Doc Link 15541765 Disease Relevance 0.41 Pain Relevance 0.21
Proposed molecular mechanisms, underlying this effect, include inhibition of the intracellular NF-kappaB pathway [55] and activation of nuclear translocation of the glucocorticoid receptor [56].
Localization (translocation) of glucocorticoid receptor
10) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 1.36 Pain Relevance 0.13
Adrenalectomy or glucocorticoid receptor blockade exacerbates the disease state and results in death or disease expression in surviving animals [139,166,167].
Localization (blockade) of glucocorticoid receptor associated with disease and death
11) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 1.27 Pain Relevance 0.42
They act by binding to a specific glucocorticoid receptor (GR) that on activation translocates to the nucleus and either increases (transactivates) or decreases (transrepresses) the expression of responsive genes.
Localization (translocates) of glucocorticoid receptor in nucleus
12) Confidence 0.03 Published 2001 Journal Immunol. Cell Biol. Section Abstract Doc Link 11488985 Disease Relevance 1.00 Pain Relevance 0.34
The glucocorticoid–receptor interaction causes a receptor conformational change which leads to regulatory protein detachment, dimerization of the glucocorticoid receptor complexes and translocation to the nucleus where the drug-receptor complex binds to specific regulatory DNA sequences (glucocorticoid response elements, GRE), which modulate the expression of the adjacent genes.
Localization (translocation) of glucocorticoid receptor in nucleus
13) Confidence 0.01 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707800 Disease Relevance 0.53 Pain Relevance 0.12

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