INT5283

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Context Info
Confidence 0.70
First Reported 1984
Last Reported 2010
Negated 12
Speculated 3
Reported most in Abstract
Documents 191
Total Number 194
Disease Relevance 66.77
Pain Relevance 109.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
arcuate nucleus 13
neurons 11
DRG 7
plasma 6
nerve 6
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 586 100.00 Very High Very High Very High
dorsal root ganglion 135 100.00 Very High Very High Very High
Enkephalin 115 100.00 Very High Very High Very High
agonist 95 100.00 Very High Very High Very High
Nucleus accumbens 85 100.00 Very High Very High Very High
substance P 82 100.00 Very High Very High Very High
Calcitonin gene-related peptide 75 100.00 Very High Very High Very High
Somatostatin 56 100.00 Very High Very High Very High
Dopamine 41 100.00 Very High Very High Very High
noradrenaline 28 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 161 100.00 Very High Very High Very High
Aids-related Complex 79 100.00 Very High Very High Very High
Injury 168 99.98 Very High Very High Very High
Diabetes Mellitus 105 99.98 Very High Very High Very High
Hypersensitivity 44 99.92 Very High Very High Very High
Stress 90 99.88 Very High Very High Very High
Convulsion 71 99.80 Very High Very High Very High
Nervous System Injury 134 99.76 Very High Very High Very High
Pain 86 99.76 Very High Very High Very High
Urological Neuroanatomy 28 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sciatic nerve ligation resulted in significant increase in the NPY-immunoreactive (NPY-ir) fibers in ventrolateral periaqueductal gray (VLPAG) and locus coeruleus (LC); fibers in the dorsal part of dorsal raphe nucleus (DRD) did not respond.
Positive_regulation (increase) of NPY in locus coeruleus associated with locus ceruleus, sciatic nerve, raphe and central grey
1) Confidence 0.70 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19556004 Disease Relevance 0.83 Pain Relevance 2.42
These data suggest the selective mediation of nerve injury-induced tactile hypersensitivity by upregulated NPY via large fiber input to n. gracilis.
Positive_regulation (upregulated) of NPY in nerve associated with nervous system injury and hypersensitivity
2) Confidence 0.70 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12427842 Disease Relevance 1.54 Pain Relevance 0.48
Clonidine administration increases neuropeptide Y immunoreactivity and neuropeptide Y mRNA in the rat cerebral cortex neurons.
Positive_regulation (increases) of neuropeptide Y in cerebral cortex associated with neuropeptide, cerebral cortex and clonidine
3) Confidence 0.70 Published 1997 Journal Neuropeptides Section Title Doc Link 9243515 Disease Relevance 0 Pain Relevance 0.57
Based on experiments in the pithed guinea-pig, it is suggested that the PNS-induced increase of the plasma NPY-LI level is modulated by a prejunctional alpha 2-adrenoceptor mediated inhibitory control mechanism, since the alpha 2-agonist clonidine was found to reduce and the alpha 2-antagonist yohimbine to markedly enhance the PNS-induced increase in plasma NPY-LI, whereas the alpha 1-antagonist prazosin had no effect.
Positive_regulation (increase) of NPY in plasma associated with antagonist, agonist and clonidine
4) Confidence 0.70 Published 1989 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2557726 Disease Relevance 0 Pain Relevance 0.45
Negative energy balance, such as food deprivation, increases NPY mRNA in hypothalamic arcuate nucleus (ARC).
Positive_regulation (increases) of NPY in ARC associated with aids-related complex
5) Confidence 0.69 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8760232 Disease Relevance 0.25 Pain Relevance 0.18
Anterior open bite as a clinical sign of joint destruction was found to be associated with high levels of NPY and IL-1beta in the synovial fluid.
Positive_regulation (levels) of NPY in synovial fluid
6) Confidence 0.69 Published 1998 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 9461143 Disease Relevance 0.21 Pain Relevance 0
In association with this augmentation of LH response, NAL infusion significantly increased NPY concentrations selectively in the median eminence, medial preoptic area, and arcuate nucleus.
Positive_regulation (increased) of NPY in arcuate nucleus associated with narcan and urological neuroanatomy
7) Confidence 0.69 Published 1990 Journal Endocrinology Section Abstract Doc Link 2404749 Disease Relevance 0.19 Pain Relevance 0.58
NPY mRNA increase was correlated to increased cell proliferation in the subgranular zone of dentate gyrus.
Positive_regulation (increase) of NPY in dentate gyrus
8) Confidence 0.69 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16034445 Disease Relevance 0.60 Pain Relevance 0.99
Running increased NPY mRNA in dentate gyrus and the CA4 region in FSL, but not in FRL rats.
Neg (not) Positive_regulation (increased) of NPY in dentate gyrus
9) Confidence 0.69 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16034445 Disease Relevance 0.53 Pain Relevance 0.92
Drinking of saccharin in turn elevated the mRNA levels of orexin and NPY, but not MCH.
Positive_regulation (elevated) of NPY
10) Confidence 0.68 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 17010451 Disease Relevance 0.08 Pain Relevance 0.50
We have reported previously that blockade of EOP influence by the opioid receptor antagonist, naloxone (NAL), stimulated NPY accumulation in the median eminence (ME) in association with increased LH release in estradiol-17 beta-primed ovariectomized rats.
Positive_regulation (accumulation) of NPY in median eminence associated with antagonist, narcan and opioid receptor
11) Confidence 0.68 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0 Pain Relevance 0.54
Robust but transient increases of neuropeptide Y, neurokinin B, and Met-enkephalin mRNA levels were revealed in the granule cell layer of the dentate gyrus and increased neuropeptide Y and neurokinin B immunoreactivities were found in mossy fibers.
Positive_regulation (increases) of neuropeptide Y in granule cell associated with neuropeptide and enkephalin
12) Confidence 0.67 Published 1998 Journal Synapse Section Abstract Doc Link 9661251 Disease Relevance 0.36 Pain Relevance 0.69
Pretreatment with capsaicin did not affect the increased level of NPY-LI in the ankle joint of arthritic rats.
Neg (not) Positive_regulation (increased) of NPY in ankle joint associated with qutenza and arthritis
13) Confidence 0.67 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7566511 Disease Relevance 0.79 Pain Relevance 0.76
Pre-treatment of rats with thiopental prior to kainic acid prevented seizures, the decline in catecholamines and the elevation of enkephalin and neuropeptide Y mRNAs but not that of chromogranin B.
Positive_regulation (elevation) of neuropeptide Y associated with convulsion, catecholamine, neuropeptide and enkephalin
14) Confidence 0.67 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9427505 Disease Relevance 0.31 Pain Relevance 0.52
This treatment increased mRNA steady-state levels of enkephalin, neuropeptide Y and chromogranin B 2-6-fold.
Positive_regulation (increased) of neuropeptide Y associated with neuropeptide and enkephalin
15) Confidence 0.67 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9427505 Disease Relevance 0.24 Pain Relevance 0.50
These results indicate that stimulation of the NPY receptors and alpha-adrenoceptors in the nTS region may cause inhibition of the adenylate cyclase.
Positive_regulation (stimulation) of NPY
16) Confidence 0.67 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3035437 Disease Relevance 0 Pain Relevance 0.31
In the FSL rats, NPY mRNA expression levels were significantly decreased in the nucleus accumbens and CA regions, but increased in the arcuate nucleus and anterior cingulate cortex.
Positive_regulation (increased) of NPY in anterior associated with nucleus accumbens and anterior cingulate cortex
17) Confidence 0.66 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.38 Pain Relevance 0.65
Following the nerve cut, RNA blot analysis demonstrated a dramatic induction of NPY, VIP, and GAL mRNA levels from the undetectable constitutive level of expression.
Positive_regulation (induction) of NPY in nerve
18) Confidence 0.66 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7685398 Disease Relevance 0.07 Pain Relevance 0.71
Anticonvulsant treatment with thiopental, after a brief period of generalized seizures, prevented the increase in NPY mRNA in granule cells but not in interneurons.
Positive_regulation (increase) of NPY in interneurons associated with convulsion and anticonvulsant
19) Confidence 0.66 Published 1994 Journal Hippocampus Section Abstract Doc Link 7874238 Disease Relevance 0.51 Pain Relevance 0.19
In the granule cell layer only a transient but pronounced increase in NPY mRNA was observed 12-24 h after injection.
Positive_regulation (increase) of NPY in granule cell
20) Confidence 0.66 Published 1994 Journal Hippocampus Section Abstract Doc Link 7874238 Disease Relevance 0.52 Pain Relevance 0.16

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