INT5284

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2009
Negated 2
Speculated 5
Reported most in Abstract
Documents 25
Total Number 30
Disease Relevance 12.91
Pain Relevance 7.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
articular 1
leukocyte 1
juvenile 1
lymphocyte 1
B65 1
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 125 100.00 Very High Very High Very High
cytokine 6 100.00 Very High Very High Very High
Arthritis 19 98.84 Very High Very High Very High
Inflammation 13 88.32 High High
cINOD 3 88.20 High High
rheumatoid arthritis 13 88.08 High High
aspirin 1 86.36 High High
imagery 3 52.88 Quite High
tolerance 3 26.96 Quite Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 75 100.00 Very High Very High Very High
Seronegative Spondarthritis 75 100.00 Very High Very High Very High
Syndrome 7 100.00 Very High Very High Very High
Pneumonia 6 100.00 Very High Very High Very High
Infection 5 100.00 Very High Very High Very High
Spondylarthropathies 4 99.98 Very High Very High Very High
Disease 114 99.96 Very High Very High Very High
Disease Susceptibility 4 99.26 Very High Very High Very High
Arthropathy 2 97.78 Very High Very High Very High
Arthritis 5 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cysteine exposure in the HLA-B27 heavy chain is also affected by residues within the 114 and 116 regions, thereby providing a potential biochemical basis for the association of HLA-B27 subtypes with AS.


Regulation (affected) of HLA-B27 heavy chain
1) Confidence 0.59 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18975339 Disease Relevance 0 Pain Relevance 0
We employed crystallographic and functional studies to investigate whether the exchange of arginine to citrulline affects the display of a peptide by two human major histocompatibility antigen class I subtypes, HLA-B(*)2705 and HLA-B(*)2709.
Spec (whether) Regulation (affects) of HLA-B
2) Confidence 0.45 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18650441 Disease Relevance 0.26 Pain Relevance 0.18
We employed crystallographic and functional studies to investigate whether the exchange of arginine to citrulline affects the display of a peptide by two human major histocompatibility antigen class I subtypes, HLA-B(*)2705 and HLA-B(*)2709.
Spec (whether) Regulation (affects) of HLA-B
3) Confidence 0.45 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18650441 Disease Relevance 0.27 Pain Relevance 0.18
The major purpose of the present study was to investigate the frequency of human leukocyte antigen (HLA)-B27 alleles in healthy controls and in patients with ankylosing spondylitis (AS) and other HLA-B27-related diseases in the Greek Cypriot population.
Spec (investigate) Regulation (frequency) of HLA-B27-related in leukocyte associated with spinal inflammation and disease
4) Confidence 0.44 Published 2004 Journal Hum. Immunol. Section Abstract Doc Link 15603872 Disease Relevance 0.56 Pain Relevance 0.33
We also considered the HLA B27 antigen, the serum immunoglobulin A levels, the disease activity, the existence of peripheral arthritis, the ESR, the CRP values and the intake of drugs at the time of study.
Regulation (considered) of HLA B27 associated with seronegative spondarthritis, disease and arthritis
5) Confidence 0.44 Published 1994 Journal Br. J. Rheumatol. Section Abstract Doc Link 8019793 Disease Relevance 0.65 Pain Relevance 0.20
[Role of enteric Klebsiella pneumonia infection and HLA-B27 in ankylosing spondylitis].
Regulation ([Role) of HLA-B27 associated with spinal inflammation, pneumonia and infection
6) Confidence 0.41 Published 1992 Journal Zhonghua Nei Ke Za Zhi Section Title Doc Link 1298592 Disease Relevance 1.63 Pain Relevance 0.59
The aim of this study was to determine the influence of HLA-B27 homozygosity on the clinical manifestations of AS in Korea.
Spec (determine) Regulation (influence) of HLA-B27 homozygosity associated with spinal inflammation
7) Confidence 0.39 Published 2009 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 19772787 Disease Relevance 0.55 Pain Relevance 0.46
Moreover, multiple factors along the antigen processing-loading pathway, including tapasin, contribute to shaping the HLA-B27 repertoire.
Regulation (contribute) of HLA-B27 repertoire
8) Confidence 0.39 Published 2000 Journal Curr Opin Rheumatol Section Abstract Doc Link 10910175 Disease Relevance 0.23 Pain Relevance 0.09
Differences in peptide binding did not affect the ratio of native to beta2-microglobulin-free HLA-B27 heavy chain at the cell surface.
Neg (not) Regulation (affect) of HLA-B27 heavy chain
9) Confidence 0.35 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12042320 Disease Relevance 0.14 Pain Relevance 0.23
The substitution of the HLA-ABC-m3 with the recently available HLA-B27 specific MoAb FD705 would substantially increase the value of this technique for routine HLA-B27 typing.
Regulation (value) of HLA-B27
10) Confidence 0.33 Published 1994 Journal Cytometry Section Abstract Doc Link 7924699 Disease Relevance 0 Pain Relevance 0
The present results are interpreted as an indication of a direct involvement of the HLA-B locus in the pathogenesis of AS.
Regulation (involvement) of HLA-B associated with spinal inflammation
11) Confidence 0.26 Published 1984 Journal Z Rheumatol Section Abstract Doc Link 6335328 Disease Relevance 0.43 Pain Relevance 0.43
Out of 52 Hardy-Weinberg analyses (26 analyses of controls and 26 of cases), three resulted in disequilibrium at p < 0.05, as expected by chance: HLA-B39 controls, HLA-B51 cases and HLA-B65 cases, each due to a single homozygote of a relatively rare allele.
Regulation (controls) of HLA-B39 in B65
12) Confidence 0.24 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.18 Pain Relevance 0
As to antigens of the HLA-complex class I, attention was paid in particular to the importance of HLA B 27 in ankylosing spondylitis, other spondylarthropathies and reactive arthritis; in this part the review is supplemented by results of the authors' own research.
Regulation (importance) of HLA B 27 associated with seronegative spondarthritis, spinal inflammation, spondylarthropathies and arthritis
13) Confidence 0.23 Published 1993 Journal Vnitr Lek Section Abstract Doc Link 8284907 Disease Relevance 0.61 Pain Relevance 0.19
METHODS: PBL from 55 HLA-B27+ patients with ankylosing spondylitis (AS), 28 HLA-B27+ patients with other spondylarthropathies, 7 rheumatoid arthritis patients, and 30 HLA-B27+ and 22 HLA-B27- healthy controls were tested in lymphocyte proliferation assays with 4 synthetic peptides derived from the HLA-B*2705 molecule.
Regulation (controls) of HLA-B27 in lymphocyte
14) Confidence 0.23 Published 1997 Journal Arthritis Rheum. Section Body Doc Link 9365095 Disease Relevance 0.09 Pain Relevance 0
The purpose of the present study is to investigate the frequency of HLA-B27 and its alleles in reactive arthritis (ReA) and in ankylosing spondylitis (AS) in Tunisia.
Spec (investigate) Regulation (frequency) of HLA-B27 associated with seronegative spondarthritis, spinal inflammation and arthritis
15) Confidence 0.23 Published 2009 Journal Rheumatol. Int. Section Abstract Doc Link 19152094 Disease Relevance 1.00 Pain Relevance 0.59
We subtyped HLA-B27 in 38 HLA-B27-positive Turkish patients with AS and 47 HLA-B27-positive healthy controls without AS by polymerase chain reaction with specific sequence primers (PCR-SSP).
Regulation (controls) of HLA-B27-positive associated with spinal inflammation
16) Confidence 0.22 Published 2006 Journal Rheumatol. Int. Section Abstract Doc Link 16032389 Disease Relevance 0.46 Pain Relevance 0.46
Subtyping by SSO was performed in 142 patients with HLA-B27 associated disease [ankylosing spondylitis (AS) n = 38, reactive arthritis 44, undifferentiated spondyloarthropathy (uSpA) 45, psoriatic arthritis 15] and 125 healthy HLA-B27 controls.
Regulation (controls) of HLA-B27
17) Confidence 0.20 Published 1997 Journal J. Rheumatol. Section Body Doc Link 9150078 Disease Relevance 0.08 Pain Relevance 0
Of 88 HLA-B27 positive individuals from these villages, all had HLA-B*2705, including the four patients with Reiter's syndrome and the five ankylosing spondylitis, except one Eskimo control who had HLA-B*2702.
Neg (except) Regulation (control) of HLA-B in Reiter associated with spinal inflammation and syndrome
18) Confidence 0.18 Published 1995 Journal Tissue Antigens Section Abstract Doc Link 8838347 Disease Relevance 0.20 Pain Relevance 0.10
Influence of HLA-B*5703 and HLA-B*1403 on susceptibility to spondyloarthropathies in the Zambian population.
Regulation (Influence) of HLA-B
19) Confidence 0.13 Published 2008 Journal J. Rheumatol. Section Title Doc Link 18925686 Disease Relevance 0 Pain Relevance 0.13
Our aim was to scan the effect of a panel of cytokines on the promoter of the HLA-B27 gene over serial timepoints.
Regulation (effect) of HLA-B27 gene associated with cytokine
20) Confidence 0.12 Published 2008 Journal J. Rheumatol. Section Abstract Doc Link 18381783 Disease Relevance 0.09 Pain Relevance 0.18

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