INT5285

Context Info Confidence 0.41 First Reported 1992 Last Reported 2006 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 3.39 Pain Relevance 0.68

plasma membrane (HLA-B)

Anatomy Link Frequency leukocyte 2 T cells 2 HLA-B (Homo sapiens)

Pain Link Frequency Relevance Heat spinal inflammation 11 99.84 cytokine 14 54.80 Arthritis 8 5.00 rheumatoid arthritis 3 5.00 headache 2 5.00 palliative 1 5.00 Inflammation 1 5.00 Angina 1 5.00 anticonvulsant 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Infection 13 100.00 Pneumonia 6 100.00 Disease Susceptibility 2 100.00 Low Back Pain 10 99.84 Chlamydia Infection 88 98.28 Cancer 59 97.96 Esophageal Cancer 1 90.56 Epstein-barr Virus 18 88.32 Targeted Disruption 4 80.72 Skin Cancer 2 79.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

[Role of enteric Klebsiella pneumonia infection and HLA-B27 in ankylosing spondylitis].

Regulation ([Role) of Gene_expression (infection) of HLA-B27 associated with spinal inflammation, pneumonia and infection

1) Confidence 0.41 Published 1992 Journal Zhonghua Nei Ke Za Zhi Section Title Doc Link 1298592 Disease Relevance 1.63 Pain Relevance 0.59

Generation of antigen-specific CD8+ T cell lines after MACS sorting of HLA-B27 tetramer-positive T cells

Regulation (specific) of Gene_expression (lines) of HLA-B27 tetramer in T cells

2) Confidence 0.36 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.39 Pain Relevance 0.03

In contrast, when HLA-B*2702 is expressed with beta2m of human origin, disease susceptibility is not affected.

Neg (not) Regulation (affected) of Gene_expression (expressed) of HLA-B associated with disease susceptibility

3) Confidence 0.34 Published 1997 Journal Immunogenetics Section Abstract Doc Link 9148786 Disease Relevance 0.82 Pain Relevance 0.07

As for CTA, DNA methylation participates in regulation of the expression of the three classes of human leukocyte antigen class I antigens: HLA-A; HLA-B, and HLA-C, which are CpG-rich at their gene promoters.

Regulation (regulation) of Gene_expression (expression) of HLA-B in leukocyte

4) Confidence 0.09 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.56 Pain Relevance 0

General Comments

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