INT5285

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.39
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
leukocyte 2
T cells 2
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 11 99.84 Very High Very High Very High
cytokine 14 54.80 Quite High
Arthritis 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 13 100.00 Very High Very High Very High
Pneumonia 6 100.00 Very High Very High Very High
Disease Susceptibility 2 100.00 Very High Very High Very High
Low Back Pain 10 99.84 Very High Very High Very High
Chlamydia Infection 88 98.28 Very High Very High Very High
Cancer 59 97.96 Very High Very High Very High
Esophageal Cancer 1 90.56 High High
Epstein-barr Virus 18 88.32 High High
Targeted Disruption 4 80.72 Quite High
Skin Cancer 2 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Role of enteric Klebsiella pneumonia infection and HLA-B27 in ankylosing spondylitis].
Regulation ([Role) of Gene_expression (infection) of HLA-B27 associated with spinal inflammation, pneumonia and infection
1) Confidence 0.41 Published 1992 Journal Zhonghua Nei Ke Za Zhi Section Title Doc Link 1298592 Disease Relevance 1.63 Pain Relevance 0.59
Generation of antigen-specific CD8+ T cell lines after MACS sorting of HLA-B27 tetramer-positive T cells
Regulation (specific) of Gene_expression (lines) of HLA-B27 tetramer in T cells
2) Confidence 0.36 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.39 Pain Relevance 0.03
In contrast, when HLA-B*2702 is expressed with beta2m of human origin, disease susceptibility is not affected.
Neg (not) Regulation (affected) of Gene_expression (expressed) of HLA-B associated with disease susceptibility
3) Confidence 0.34 Published 1997 Journal Immunogenetics Section Abstract Doc Link 9148786 Disease Relevance 0.82 Pain Relevance 0.07
As for CTA, DNA methylation participates in regulation of the expression of the three classes of human leukocyte antigen class I antigens: HLA-A; HLA-B, and HLA-C, which are CpG-rich at their gene promoters.
Regulation (regulation) of Gene_expression (expression) of HLA-B in leukocyte
4) Confidence 0.09 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.56 Pain Relevance 0

General Comments

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