INT5286

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2011
Negated 3
Speculated 3
Reported most in Body
Documents 46
Total Number 49
Disease Relevance 21.06
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ANTXR2) endoplasmic reticulum (ANTXR2) plasma membrane (ANTXR2)
Anatomy Link Frequency
retina 2
chondrocytes 1
Notch 1
embryos 1
spinal cords 1
ANTXR2 (Homo sapiens)
ANTXR2 - L154D (1)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 53 99.84 Very High Very High Very High
dorsal root ganglion 5 98.92 Very High Very High Very High
trigeminal ganglion 2 98.64 Very High Very High Very High
headache 6 97.84 Very High Very High Very High
abdominal pain 4 95.88 Very High Very High Very High
Sciatic nerve 1 93.04 High High
qutenza 16 90.56 High High
tetrodotoxin 9 89.92 High High
Neuropathic pain 2 89.44 High High
Nerve growth factor 60 87.92 High High
Disease Link Frequency Relevance Heat
Hypertension 1246 100.00 Very High Very High Very High
Targeted Disruption 373 100.00 Very High Very High Very High
Papillomavirus Infection 143 100.00 Very High Very High Very High
Head Trauma 6 100.00 Very High Very High Very High
Poisoning 302 99.80 Very High Very High Very High
Pressure And Volume Under Development 148 99.42 Very High Very High Very High
Ganglion Cysts 153 98.64 Very High Very High Very High
Headache 13 97.84 Very High Very High Very High
Appetite Loss 2 96.68 Very High Very High Very High
Cardiovascular Disease 106 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the trigeminal ganglion of mouse embryos, GFRalpha1 and GFRalpha2 mRNAs can be detected by ISH preceding ret expression (Luukko et al. 1997).
Gene_expression (expression) of ISH in embryos associated with ganglion cysts and trigeminal ganglion
1) Confidence 0.75 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.10 Pain Relevance 0.43
Clrn1 ISH was clearly detectable at P7 in the INL (Figure 2G).
Gene_expression (detectable) of ISH
2) Confidence 0.75 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.53 Pain Relevance 0
At P60, GFRalpha3 expression is undetectable by ISH (Nishino et al. 1999).
Gene_expression (undetectable) of ISH
3) Confidence 0.65 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.31 Pain Relevance 0
Additionally, staining of P7 mouse retina shows co-labeling of Clrn1 ISH with a Glast antibody (Figure S2).
Gene_expression (labeling) of ISH in retina
4) Confidence 0.65 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0 Pain Relevance 0
We also double-labeled P7 retinal sections for Clrn1 ISH and Sox9 immunohistochemistry (Figure 3G–3J).
Gene_expression (sections) of ISH
5) Confidence 0.65 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0 Pain Relevance 0
ISH with a Clrn1 riboprobe on adult human retina did not generate a significant signal (data not shown).
Gene_expression (riboprobe) of ISH in retina
6) Confidence 0.65 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.39 Pain Relevance 0
However, these data were consistent with the Kiss1 ISH analysis that only demonstrated a difference in Kiss1 expression in the AVPV of WT and hpg females but no difference between WT and hpg males at pubertal ages.


Gene_expression (analysis) of ISH
7) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.22 Pain Relevance 0
To examine the expression patterns of exogenous human G0S2 in various transgenic mouse tissues, we first performed ISH analysis.
Spec (examine) Gene_expression (expression) of ISH associated with targeted disruption
8) Confidence 0.65 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.00 Pain Relevance 0
Interestingly, PLD4 ISH signals in the cerebellar white matter closely matched IHC signals for Iba1 (a microglial marker) [29] (as shown in the rightmost panels of Fig. 5A–C).
Gene_expression (signals) of ISH in cerebellar white matter
9) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0 Pain Relevance 0.04
In this study we used in situ hybridization histochemistry (ISH) to determine synthesis of CGRP mRNA in lumbar L4 dorsal root ganglion (DRG) cells during NGF-induced regeneration.
Spec (determine) Gene_expression (synthesis) of ISH in DRG associated with ganglion cysts, dorsal root ganglion and calcitonin gene-related peptide
10) Confidence 0.65 Published 1999 Journal Neurosci. Res. Section Abstract Doc Link 10605941 Disease Relevance 0.36 Pain Relevance 0.86
PA receptor–deficient CHO-R1.1 cells and CHO-R1.1 cells that were engineered to stably express recombinant receptor-EGFP fusion proteins, CMG2489-EGFP or ATR/TEM8 sv2-EGFP, have been described previously [22,34].
Gene_expression (express) of CMG2
11) Confidence 0.58 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0 Pain Relevance 0
Left cerebellar haematoma and ISH were found in cranial MRI and cranial computed tomography Cranial MR angiogram was normal.
Gene_expression (found) of ISH in Cranial associated with head trauma
12) Confidence 0.58 Published 2005 Journal J Headache Pain Section Abstract Doc Link 16362191 Disease Relevance 0.98 Pain Relevance 0.29
T-2 toxin was found in the mouldy rice and the highest content was 420 ppb.
Gene_expression (found) of T-2 toxin
13) Confidence 0.54 Published 1992 Journal Zhonghua Yu Fang Yi Xue Za Zhi Section Abstract Doc Link 1298606 Disease Relevance 0.72 Pain Relevance 0.10
T-2 toxin was found in these moldy rice and the highest level was 420 ppb.
Gene_expression (found) of T-2 toxin
14) Confidence 0.47 Published 1993 Journal Biomed. Environ. Sci. Section Abstract Doc Link 8476534 Disease Relevance 0.64 Pain Relevance 0.09
Pathophysiology of ISH and its Cardiac Sequel
Gene_expression (Pathophysiology) of ISH associated with hypertension
15) Confidence 0.33 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.36 Pain Relevance 0
Pathophysiology of ISH and the Perioperative Period
Gene_expression (Pathophysiology) of ISH associated with hypertension
16) Confidence 0.33 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 0.95 Pain Relevance 0
Definition and Classification of ISH:
Gene_expression (Definition) of ISH associated with hypertension
17) Confidence 0.33 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.27 Pain Relevance 0
Perioperative ISH as a Cardiac Risk Factor in Low-Risk Patients
Gene_expression (Perioperative) of ISH associated with hypertension
18) Confidence 0.33 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 0.92 Pain Relevance 0.20
Prevalence of the Perioperative ISH
Gene_expression (Prevalence) of ISH associated with hypertension
19) Confidence 0.33 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.18 Pain Relevance 0.03
Nevertheless, it seems appropriate to defer elective surgery where possible in patients with stage 2 ISH (SBP ?
Gene_expression (stage) of ISH associated with hypertension
20) Confidence 0.33 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.45 Pain Relevance 0.25

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