INT52871

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Context Info
Confidence 0.60
First Reported 1995
Last Reported 2006
Negated 1
Speculated 4
Reported most in Abstract
Documents 6
Total Number 12
Disease Relevance 3.26
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdc) lyase activity (Hdc) cellular amino acid metabolic process (Hdc)
Anatomy Link Frequency
stomach 2
gingiva 1
ear skin 1
dental pulp 1
Hdc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 10 100.00 Very High Very High Very High
dexamethasone 6 100.00 Very High Very High Very High
aspirin 3 100.00 Very High Very High Very High
Inflammation 5 99.56 Very High Very High Very High
antinociception 1 98.44 Very High Very High Very High
Morphine 12 98.24 Very High Very High Very High
Cholecystokinin 1 94.08 High High
analgesia 6 91.68 High High
Somatostatin 3 91.24 High High
Hyperalgesia 1 86.68 High High
Disease Link Frequency Relevance Heat
Stress 21 100.00 Very High Very High Very High
INFLAMMATION 5 99.56 Very High Very High Very High
Disease 10 98.88 Very High Very High Very High
Necrosis 3 92.08 High High
Cancer 3 91.72 High High
Hyperalgesia 1 86.68 High High
Cognitive Disorder 2 75.00 Quite High
Pulpitis 5 43.12 Quite Low
Mouth Disease 5 42.16 Quite Low
Periodontitis 5 41.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possible participation of histidine decarboxylase in gastric lesions is discussed on the basis of the known actions of histamine, our findings and the effect of histamine H(2) receptor antagonists on histidine decarboxylase activity.
Regulation (effect) of histidine decarboxylase associated with antagonist
1) Confidence 0.60 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12535861 Disease Relevance 0.26 Pain Relevance 0.23
To examine the potential role of the histamine-forming enzyme, histidine decarboxylase (HDC), in oral inflammation and disease, we studied HDC activity in oral tissue after induction by bacterial agents.
Spec (examine) Regulation (role) of histidine decarboxylase associated with inflammation and disease
2) Confidence 0.45 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.20 Pain Relevance 0.05
To examine the potential role of the histamine-forming enzyme, histidine decarboxylase (HDC), in oral inflammation and disease, we studied HDC activity in oral tissue after induction by bacterial agents.
Spec (examine) Regulation (role) of HDC associated with inflammation and disease
3) Confidence 0.45 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.20 Pain Relevance 0.05
To examine the contribution of the histamine-forming enzyme, histidine decarboxylase, to drug-induced gastric lesions, we compared the effects of aspirin, indomethacin and dexamethasone on histidine decarboxylase activity in mice.
Regulation (effects) of histidine decarboxylase associated with aspirin and dexamethasone
4) Confidence 0.44 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12535861 Disease Relevance 0.20 Pain Relevance 0.23
The effects of an H2 receptor antagonist, a histidine decarboxylase inhibitor and a histamine precursor on the morphine-induced place preference in mice were examined.
Spec (examined) Regulation (effects) of histidine decarboxylase associated with antagonist and morphine
5) Confidence 0.28 Published 1995 Journal Brain Res. Section Abstract Doc Link 7796129 Disease Relevance 0 Pain Relevance 0.65
By contrast, saline injection had no effect on the HDC activity in any of the four tissues, although basal levels of HDC activity in ear skin was markedly higher than basal HDC activity in the other three kinds of tissues.
Neg (no) Regulation (effect) of HDC in ear skin
6) Confidence 0.27 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.12 Pain Relevance 0.03
The possible participation of histidine decarboxylase in gastric lesions is discussed on the basis of the known actions of histamine, our findings and the effect of histamine H(2) receptor antagonists on histidine decarboxylase activity.
Spec (possible) Regulation (participation) of histidine decarboxylase associated with antagonist
7) Confidence 0.26 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12535861 Disease Relevance 0.28 Pain Relevance 0.25
Following injection of E. coli-derived lipopolysaccharide (LPS) into mice, we measured the quantitative changes in HDC activity over time in dental pulp and gingiva.
Regulation (changes) of HDC in gingiva
8) Confidence 0.24 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.18 Pain Relevance 0.05
Effect of repeated cold stress on mouse stomach histidine decarboxylase.
Regulation (Effect) of stomach histidine decarboxylase in stomach associated with stress
9) Confidence 0.24 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Title Doc Link 8750791 Disease Relevance 0.88 Pain Relevance 0.09
Following injection of E. coli-derived lipopolysaccharide (LPS) into mice, we measured the quantitative changes in HDC activity over time in dental pulp and gingiva.
Regulation (changes) of HDC in dental pulp
10) Confidence 0.08 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.18 Pain Relevance 0.05
We compared the responses of rat stomach ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) to food intake, oral treatment with antisecretagogues, NaHCO3, and hypertonic NaCl, antrectomy, intravenous infusion of gastrin-17, the selective cholecystokinin (CCK)-B/gastrin receptor antagonist L-365,260, and the somatostatin analogue RC-160.
Regulation (responses) of HDC in stomach associated with antagonist, somatostatin and cholecystokinin
11) Confidence 0.07 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8638714 Disease Relevance 0 Pain Relevance 0.14
Therefore, we studied the effect of L-histidine and histamine-receptor antagonists on antinociception and impaired retention induced by immobilization stress.
Regulation (effect) of L-histidine associated with stress, antinociception and antagonist
12) Confidence 0.01 Published 2002 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 12428429 Disease Relevance 0.77 Pain Relevance 0.71

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