INT52876

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Context Info
Confidence 0.77
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 6.87
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 1
neuronal 1
cranial 1
brain 1
H3 (Mus musculus)
Pain Link Frequency Relevance Heat
anticonvulsant 1 99.78 Very High Very High Very High
antagonist 5 98.84 Very High Very High Very High
trigeminal ganglion 198 98.72 Very High Very High Very High
Pain 7 95.16 Very High Very High Very High
Neurotransmitter 11 94.24 High High
Potency 34 83.72 Quite High
noradrenaline 1 82.24 Quite High
monoamine 3 77.88 Quite High
metalloproteinase 6 70.36 Quite High
Neurobehavioral 1 70.24 Quite High
Disease Link Frequency Relevance Heat
Bacterial Respiratory Disease 330 100.00 Very High Very High Very High
Cold Sores 267 99.56 Very High Very High Very High
Ganglion Cysts 210 98.72 Very High Very High Very High
Cognitive Disorder 1 96.04 Very High Very High Very High
Pain 7 95.16 Very High Very High Very High
Sprains And Strains 159 95.12 Very High Very High Very High
Rhinitis 1 94.92 High High
Cancer 82 94.72 High High
Obesity 2 94.00 High High
Cervical Cancer 5 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity.
Gene_expression (expressed) of H3 in neuronal associated with pain, rhinitis, cognitive disorder, antagonist and obesity
1) Confidence 0.77 Published 2004 Journal Mini Rev Med Chem Section Abstract Doc Link 15544558 Disease Relevance 0.38 Pain Relevance 0.22
Normally, H3 acetylation is associated with the regulatory sequences in the promoters of actively transcribed genes.
Gene_expression (acetylation) of H3
2) Confidence 0.31 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.50 Pain Relevance 0.18
The Msc gene is also normally silent, but it exhibits increased expression at both cranial and spinal levels in Brn3a null mice, and is accordingly H3 acetylated in both the DRG and TG.
Gene_expression (silent) of H3 in spinal associated with trigeminal ganglion
3) Confidence 0.27 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.68 Pain Relevance 0.16
No differences in histone H3 and H4 acetylation levels were, however, observed in relation to p53 status between the two cell lines.
Gene_expression (levels) of H3
4) Confidence 0.22 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.09 Pain Relevance 0
The increases in protein and acetylation levels of H3 and H4 in SAHA treated TM10 and TM2H cell lines were indicated by the strong staining with the acetylation specific antibodies of H3 and H4, while the acetylated slow migrated isoforms showed smearing due to the increases in their protein level (Fig. 5B).
Gene_expression (levels) of H3
5) Confidence 0.20 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0.04
[Possible roles of brain histamine H3 receptors and the pharmacology of its ligands].
Gene_expression (roles) of H3 in brain
6) Confidence 0.10 Published 1995 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Title Doc Link 7796325 Disease Relevance 0.41 Pain Relevance 0.33
The Msc gene is also normally silent, but it exhibits increased expression at both cranial and spinal levels in Brn3a null mice, and is accordingly H3 acetylated in both the DRG and TG.
Gene_expression (silent) of H3 in cranial associated with trigeminal ganglion
7) Confidence 0.09 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.68 Pain Relevance 0.16
We recently demonstrated, within the context of a phase I study, that magnesium valproate when used at only slightly higher doses than those utilized as anticonvulsant, not only produces H3 and H4 histone hyperacetylation in PBMN cells, but also leads to hyperacetylation of H3 and H4 hyperacetylation and HDAC activity inhibition in primary tumors of patients with cervical cancer [104].
Gene_expression (produces) of H3 associated with cervical cancer, cancer and anticonvulsant
8) Confidence 0.08 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.54 Pain Relevance 0.05
The neutral carboxylic acids Asp83 and Glu122 participate in the H1/H2/H7 and H3/H5 microdomains, respectively, and serve as valuable site-specific reporter groups for infrared spectroscopy.
Gene_expression (microdomains) of H3
9) Confidence 0.06 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0
With H3, synthetic H3–like peptides are antibacterial [121] and H3 is present in mucus extruded from the hagfish Myxine glutinous [122].
Gene_expression (present) of H3 associated with bacterial respiratory disease
10) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866484 Disease Relevance 0.19 Pain Relevance 0.03
With H3, synthetic H3–like peptides are antibacterial [121] and H3 is present in mucus extruded from the hagfish Myxine glutinous [122].
Gene_expression (synthetic) of H3 associated with bacterial respiratory disease
11) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866484 Disease Relevance 0.19 Pain Relevance 0.04
There are several types of histone of which H2A, H2B, H3 and H4 are the core histones that form the nucleosome, and H1 and H5 are the linker histones.
Gene_expression (types) of H3
12) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866484 Disease Relevance 0.34 Pain Relevance 0
With H3, synthetic H3–like peptides are antibacterial [121] and H3 is present in mucus extruded from the hagfish Myxine glutinous [122].
Gene_expression (present) of H3 associated with bacterial respiratory disease
13) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866484 Disease Relevance 0.20 Pain Relevance 0.04
Previously, we showed that both the ICP0 and ICP4 promoter regions of HSV-1 become transiently enriched in the permissive histone mark acetyl H3 K9,K14 when sodium butyrate (NaB) is used as reactivation stimuli in mice latent with the efficiently reactivating 17Syn+strain of HSV-1 [19], [22], [30].
Gene_expression (enriched) of H3 associated with cold sores and sprains and strains
14) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.76 Pain Relevance 0.04
The H3 K4me2 enrichment and RNA abundance of the LAT 5?
Gene_expression (enrichment) of H3
15) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 1.05 Pain Relevance 0
With H3, synthetic H3–like peptides are antibacterial [121] and H3 is present in mucus extruded from the hagfish Myxine glutinous [122].
Gene_expression (present) of H3 associated with bacterial respiratory disease
16) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866484 Disease Relevance 0.20 Pain Relevance 0.03
With H3, synthetic H3–like peptides are antibacterial [121] and H3 is present in mucus extruded from the hagfish Myxine glutinous [122].
Gene_expression (synthetic) of H3 associated with bacterial respiratory disease
17) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866484 Disease Relevance 0.19 Pain Relevance 0.04
exon region of HSV-1 maintains a significantly enriched H3 K4me2 chromatin profile relative to the IE regions during latency in the rabbit TG
Gene_expression (regions) of H3 associated with cold sores
18) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.47 Pain Relevance 0

General Comments

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