INT52878

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Context Info
Confidence 0.54
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.35
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (ATP6V0A1) nucleolus (ATP6V0A1) plasma membrane (ATP6V0A1)
nucleus (ATP6V0A1) transmembrane transport (ATP6V0A1) cytoplasm (ATP6V0A1)
Anatomy Link Frequency
erythrocytes 1
nerve 1
ATP6V0A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 180 100.00 Very High Very High Very High
bradykinin 41 99.80 Very High Very High Very High
lidocaine 8 96.90 Very High Very High Very High
Clonidine 2 95.72 Very High Very High Very High
agonist 90 94.08 High High
antagonist 66 89.12 High High
isoflurane 6 86.00 High High
vagus nerve 1 83.00 Quite High
b2 receptor 3 67.92 Quite High
Inflammation 5 56.00 Quite High
Disease Link Frequency Relevance Heat
Infection 168 98.52 Very High Very High Very High
Targeted Disruption 9 98.04 Very High Very High Very High
Nociception 4 83.52 Quite High
Dengue 22 71.20 Quite High
Asthma 5 59.60 Quite High
Neurodegenerative Disease 1 58.96 Quite High
INFLAMMATION 5 56.00 Quite High
Disease 9 54.96 Quite High
Cancer 4 53.92 Quite High
Neuropathic Pain 1 36.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that whilst activation of A1 and A2 adenosine receptors and alpha2 and beta adrenergic receptors does not influence basal Ca2+ levels, stimulation of these receptors can potentiate Ca2+ signalling by cAMP dependent and independent mechanisms in human RPE cells.
Positive_regulation (activation) of A1 associated with adenocard
1) Confidence 0.54 Published 2005 Journal Exp. Eye Res. Section Abstract Doc Link 15781274 Disease Relevance 0 Pain Relevance 0.43
Monoclonal antibodies specific for the cellular proteins, CLTC (Sigma Aldrich), AP2B1 (Abcam), DNM2 (Sigma Aldrich), ARRB1 (Abnova), ATP6V0A1 (Sigma Aldrich) and ARPC1B (Santa Cruz Biotechnology) were used for Western detection.
Positive_regulation (used) of ATP6V0A1
2) Confidence 0.36 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.08 Pain Relevance 0
The data suggest that ATP-induced changes in axonal excitability and of [Ca(2+)](i) result from activation of adenosine A2, A1 and P2Y nucleotide receptors in human nerve; a contribution of P2X receptors was not found with the methods used.
Positive_regulation (activation) of A1 in nerve associated with adenocard
3) Confidence 0.31 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 12382074 Disease Relevance 0.08 Pain Relevance 0.53
These results suggest that the lidocaine-induced shape change in human erythrocytes may occur by the conformational change of spectrin in a process that may be mediated by carbonic anhydrase and activation of V-ATPase.
Positive_regulation (activation) of V-ATPase in erythrocytes associated with lidocaine
4) Confidence 0.19 Published 1995 Journal Cell Struct. Funct. Section Abstract Doc Link 7796469 Disease Relevance 0 Pain Relevance 0.49
It can be observed that at least one of the four siRNAs directed against each specific gene (CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B) can result in more than 50% inhibition of DENV infection (Figure 3G) hence indicating the specificity of these genes in mediating DENV infection.
Positive_regulation (result) of ATP6V0A1 associated with infection
5) Confidence 0.15 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.80 Pain Relevance 0
Adenosine, an ubiquitous nucleoside released from metabolically active or stressed cells, is known to act as an important regulatory molecule through activation of cell surface receptors named A1, A2A, A2B and A3, all of which belong to the G protein-coupled superfamily of receptors [1].
Positive_regulation (activation) of A1 associated with adenocard
6) Confidence 0.12 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0.28 Pain Relevance 0.13
Activation of A1 and A3 receptors induces the inhibition of the enzyme adenylate cyclase mediated by an inhibitory G protein (Gi).
Positive_regulation (Activation) of A1
7) Confidence 0.11 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.21
Interestingly, 2-aminoselenophene-3-carboxylates also proved to be allosteric enhancers of A1 receptors [21].
Positive_regulation (enhancers) of A1
8) Confidence 0.07 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.41
Using gene knockout mice, it has been shown that ischemic PostC-induced decreased in infarct volume was triggered by activation of adenosine A1 and bradykinin B2 receptors [27].
Positive_regulation (activation) of A1 associated with targeted disruption, adenocard and bradykinin
9) Confidence 0.03 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.10 Pain Relevance 0.72

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