INT52901

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.92
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLAUR) extracellular region (PLAUR) plasma membrane (PLAUR)
enzyme binding (PLAUR)
Anatomy Link Frequency
neural 1
PLAUR (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
metalloproteinase 8 99.76 Very High Very High Very High
ischemia 2 97.56 Very High Very High Very High
antagonist 29 66.88 Quite High
withdrawal 1 18.28 Low Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 8 100.00 Very High Very High Very High
Muscular Spasm 1 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 1 100.00 Very High Very High Very High
Diffuse Scleroderma 6 99.06 Very High Very High Very High
Ovarian Cancer 23 98.30 Very High Very High Very High
Cv Unclassified Under Development 2 97.56 Very High Very High Very High
Cancer 65 97.32 Very High Very High Very High
Ulcers 1 84.28 Quite High
Metastasis 13 74.88 Quite High
Apoptosis 16 55.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although each of them alone has a limited effect on the painful ischemic attack in PSS; in stepwise combination, neural blockade for release of vascular spasm and pain, prostaglandin E1 for further vasodilatation, and urokinase for thrombolysis were effective in the treatment of digital ischemia in two PSS patients.
Localization (release) of urokinase in neural associated with pain, diffuse scleroderma, ischemia, muscular spasm and increased venous pressure under development
1) Confidence 0.49 Published 1994 Journal J. Dermatol. Section Abstract Doc Link 7798434 Disease Relevance 1.09 Pain Relevance 0.45
In the ovarian carcinoma cells, co-induction of uPA system, by the concomitant stimulation of production and secretion of uPA and uPAR, and MMPs by ET-1 resulted into the highest invasive potential of tumor cells through the Matrigel.
Localization (secretion) of uPAR associated with cancer, ovarian cancer and metalloproteinase
2) Confidence 0.26 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.82 Pain Relevance 0.23

General Comments

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