INT52903

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.02
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LTF) extracellular region (LTF) cytoplasm (LTF)
Anatomy Link Frequency
plasma 2
neutrophils 2
LTF (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 206 99.92 Very High Very High Very High
Action potential 12 98.98 Very High Very High Very High
qutenza 11 98.00 Very High Very High Very High
opioid receptor 42 64.72 Quite High
hyperexcitability 9 61.84 Quite High
Versed 1 41.76 Quite Low
opiate 5 41.12 Quite Low
Neuropeptide 1 25.00 Low Low
Neuronal excitability 25 15.32 Low Low
Glutamate 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 19 98.28 Very High Very High Very High
Sepsis 47 85.12 High High
Disorders Of The Lacrimal System 1 82.40 Quite High
Rhinitis 1 78.44 Quite High
Systemic Inflammatory Response Syndrome 7 58.20 Quite High
Sleep Disorders 3 39.84 Quite Low
Gram Positive Bacterium Infection 1 39.16 Quite Low
Reflex Sympathetic Dystrophy 2 28.72 Quite Low
Stress 7 24.48 Low Low
Critical Illness 4 19.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, lactoferrin, a marker of glandular secretion, was increased (p < 0.005).
Positive_regulation (increased) of Localization (secretion) of lactoferrin
1) Confidence 0.67 Published 1994 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 7798536 Disease Relevance 0.16 Pain Relevance 0.78
This may cause inefficient release of LF from the plasma proteins.
Spec (may) Positive_regulation (cause) of Localization (release) of LF in plasma
2) Confidence 0.31 Published 2010 Journal Analytical Chemistry Insights Section Body Doc Link PMC2865164 Disease Relevance 0 Pain Relevance 0
Several lines of evidence suggested that these supernumerary action potentials arose in motor axons and were responsible for the increased transmitter release underlying LTF.
Positive_regulation (increased) of Localization (release) of LTF associated with action potential
3) Confidence 0.09 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581892 Disease Relevance 0 Pain Relevance 0.33
In the present study, we have demonstrated (i) that morphine is present in human neutrophils and is colocalized with lactoferrin, an antimicrobial peptide released during infection [42] from the secondary granules of neutrophils, (ii) that LPS and IL-8 trigger the Ca2+-dependent secretion of morphine and lactoferrin in vitro, (iii) that endogenous morphine concentrations are significantly increased in the serum of patients with septic conditions, (iv) that the concentration of morphine found in sepsis inhibits IL-8 release from neutrophils and finally (v) that ?
Positive_regulation (present) of Localization (colocalized) of lactoferrin in neutrophils associated with sepsis, infection and morphine
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.86 Pain Relevance 1.00

General Comments

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