INT52904

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 21
Total Number 28
Disease Relevance 15.58
Pain Relevance 5.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LTF) extracellular region (LTF) cytoplasm (LTF)
Anatomy Link Frequency
feces 2
peripheral nerves 2
sympathetic 2
parasympathetic 2
dorsal 1
LTF (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 206 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
Clonidine 8 99.72 Very High Very High Very High
ganglionectomy 264 99.40 Very High Very High Very High
medulla 134 99.40 Very High Very High Very High
Inflammation 99 99.32 Very High Very High Very High
substance P 3 98.72 Very High Very High Very High
spastic colon 52 98.64 Very High Very High Very High
qutenza 11 98.00 Very High Very High Very High
Raphe 1 92.48 High High
Disease Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
Inflammatory Bowel Disease 243 99.88 Very High Very High Very High
Hypoxia 424 99.86 Very High Very High Very High
Pulmonary Alveolar Proteinosis 207 99.84 Very High Very High Very High
Obesity 31 99.84 Very High Very High Very High
INFLAMMATION 89 99.32 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

51 98.64 Very High Very High Very High
Infection 42 97.48 Very High Very High Very High
Stress 88 96.92 Very High Very High Very High
Sepsis 47 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, lactoferrin, a marker of glandular secretion, was increased (p < 0.005).
Positive_regulation (increased) of lactoferrin
1) Confidence 0.67 Published 1994 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 7798536 Disease Relevance 0.16 Pain Relevance 0.78
In contrast, clonidine (2.25 ng/mL) increased LTF in anesthetized subjects by 21%+/-16% and SBP from 91+/-7 to 106+/-19 mm Hg (P<0.0001).
Positive_regulation (increased) of LTF associated with clonidine
2) Confidence 0.41 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 11004028 Disease Relevance 0.39 Pain Relevance 0.73
Calprotectin and lactoferrin were significantly elevated in patients with Crohn's disease with CDAI>150 compared with those in remission.
Positive_regulation (elevated) of lactoferrin
3) Confidence 0.35 Published 2007 Journal Dis. Colon Rectum Section Body Doc Link 17762964 Disease Relevance 0 Pain Relevance 0
Hence, one objective of the present study was to determine whether or not exposure to short-term IH would increase LF activity in HRV spectra, and consequently increase LF/HF ratios, the latter an index of the relative contributions of sympathetic and parasympathetic modulation to HRV [16].
Spec (whether) Positive_regulation (increase) of LF in parasympathetic associated with hypoxia
4) Confidence 0.19 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.86 Pain Relevance 0.08
During IH, RSGX and SHAM animals had similar increases in LF activity of HRV spectra and similar durations of Q-Tc intervals.
Positive_regulation (increases) of LF associated with hypoxia and ganglionectomy
5) Confidence 0.19 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.60 Pain Relevance 0.13
Unilateral HTS induced unilateral dose-dependent increases in sensations of pain, blockage, and rhinorrhea, the weights of recovered lavage fluids, and concentrations of total protein, lactoferrin, mucoglycoprotein markers, and substance P.
Positive_regulation (induced) of lactoferrin associated with pain and substance p
6) Confidence 0.16 Published 1999 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10430743 Disease Relevance 0.34 Pain Relevance 0.31
Hence, one objective of the present study was to determine whether or not exposure to short-term IH would increase LF activity in HRV spectra, and consequently increase LF/HF ratios, the latter an index of the relative contributions of sympathetic and parasympathetic modulation to HRV [16].
Spec (whether) Positive_regulation (increase) of LF in parasympathetic associated with hypoxia
7) Confidence 0.16 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.78 Pain Relevance 0.08
Fos was also induced in a dorsal intermediate reticular zone of LTF.
Positive_regulation (induced) of LTF in dorsal
8) Confidence 0.15 Published 1996 Journal Brain Res. Section Abstract Doc Link 8822357 Disease Relevance 0.23 Pain Relevance 0.23
While both groups of animals showed significant increases of LF activity during hypoxia compared to baseline activity, the relative change in activity from baseline was similar in each group (see Table 3).
Positive_regulation (increases) of LF associated with hypoxia
9) Confidence 0.15 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.80 Pain Relevance 0.17
In fact our finding that LF areas of SHAM animals were significantly larger than those of RSGX animals was found to be a result of increased LF activity on a single day; despite such an occurrence LF areas of SHAM animals were not different from those of CON animals who breathed room air.
Positive_regulation (increased) of LF associated with ganglionectomy
10) Confidence 0.15 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.75 Pain Relevance 0.19
This finding was due to a marked increase in LF area accompanied by a decrease of HF area of similar magnitude (Fig. 3B, top and middle graphs).
Positive_regulation (increase) of LF
11) Confidence 0.14 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.08 Pain Relevance 0.12
We confirmed our microarrays findings by Real time PCR on selected upregulated genes such as Lactoferrin Lipocalin, S100P, FCGR3A, and TLR2 (Figure 2).
Positive_regulation (upregulated) of Lactoferrin
12) Confidence 0.10 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 0.29 Pain Relevance 0.13
The study found that fecal lactoferrin was 90% specific for identifying inflammation in patients with active IBD, and elevated levels of lactoferrin were 100% specific in ruling out IBS.43
Positive_regulation (elevated) of lactoferrin associated with inflammatory bowel disease, inflammation and spastic colon
13) Confidence 0.10 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.96 Pain Relevance 0.79
The neutrophil-derived proteins, lysozyme, myeloperoxidase, calprotectin, lactoferrin, and PMN-elastase, are generally elevated in the feces of IBD patients.33–39 However, fecal lactoferrin and calprotectin are more appropriate for the differentiation of chronic IBD from IBS, and their increased levels show a positive relationship with the severity of inflammation.
Positive_regulation (elevated) of lactoferrin in feces associated with inflammatory bowel disease, inflammation and spastic colon
14) Confidence 0.10 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.05 Pain Relevance 0.20
In these genotypes, the prolonged nerve terminal depolarizations that triggered LTF were revealed by recording ejps and simultaneously recording extracellularly electrical activity within the peripheral nerves during LTF onset.
Positive_regulation (triggered) of LTF in peripheral nerves
15) Confidence 0.08 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581892 Disease Relevance 0 Pain Relevance 0.14
To confirm this suggestion, we simultaneously recorded peripheral nerve electrical activity and ejps during LTF induced by 10 Hz stimulus trains.
Positive_regulation (induced) of LTF in peripheral nerve
16) Confidence 0.08 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581892 Disease Relevance 0 Pain Relevance 0.33
In the present study, we have demonstrated (i) that morphine is present in human neutrophils and is colocalized with lactoferrin, an antimicrobial peptide released during infection [42] from the secondary granules of neutrophils, (ii) that LPS and IL-8 trigger the Ca2+-dependent secretion of morphine and lactoferrin in vitro, (iii) that endogenous morphine concentrations are significantly increased in the serum of patients with septic conditions, (iv) that the concentration of morphine found in sepsis inhibits IL-8 release from neutrophils and finally (v) that ?
Positive_regulation (increased) of lactoferrin in neutrophils associated with sepsis, infection and morphine
17) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.64 Pain Relevance 1.11
Hence, one objective of the present study was to determine whether or not exposure to short-term IH would increase LF activity in HRV spectra, and consequently increase LF/HF ratios, the latter an index of the relative contributions of sympathetic and parasympathetic modulation to HRV [16].
Spec (whether) Positive_regulation (increase) of LF in sympathetic associated with hypoxia
18) Confidence 0.07 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.86 Pain Relevance 0.08
Hence, one objective of the present study was to determine whether or not exposure to short-term IH would increase LF activity in HRV spectra, and consequently increase LF/HF ratios, the latter an index of the relative contributions of sympathetic and parasympathetic modulation to HRV [16].
Spec (whether) Positive_regulation (increase) of LF in sympathetic associated with hypoxia
19) Confidence 0.05 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.78 Pain Relevance 0.08
Whereas ANOVARM demonstrated a significant global effect of epoch on the LF nu-RRI and HF nu-RRI, the GEE model showed only a non-significant trend for an increase of the mean LF nu-RRI and a mirror decrease of the mean HF nu-RRI (p = 0.056) over the monitoring period.
Positive_regulation (increase) of LF nu-RRI
20) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0 Pain Relevance 0

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