INT52905

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 1
Speculated 7
Reported most in Body
Documents 84
Total Number 96
Disease Relevance 45.68
Pain Relevance 12.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T-cell 24
lymphocytes 9
spleen 6
macrophages 4
blood 3
Cd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 762 99.98 Very High Very High Very High
Neuritis 5 99.98 Very High Very High Very High
dorsal root ganglion 588 99.76 Very High Very High Very High
Morphine 19 99.62 Very High Very High Very High
Multiple sclerosis 28 99.26 Very High Very High Very High
Inflammation 269 99.00 Very High Very High Very High
Angina 16 98.92 Very High Very High Very High
substance P 31 98.66 Very High Very High Very High
ischemia 117 98.62 Very High Very High Very High
qutenza 114 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 328 100.00 Very High Very High Very High
Necrosis 23 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 5 99.98 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1187 99.76 Very High Very High Very High
Ganglion Cysts 588 99.76 Very High Very High Very High
Pleurisy 103 99.62 Very High Very High Very High
Hypersensitivity 70 99.46 Very High Very High Very High
Diabetes Mellitus 169 99.36 Very High Very High Very High
Multiple Sclerosis 114 99.26 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 930 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Twenty hours later the rats were sacrificed and the proportion of the four major thymocyte populations defined by expression of CD4 and CD8 molecules was analyzed.
Gene_expression (expression) of CD4 in thymocyte
1) Confidence 0.78 Published 1996 Journal Alcohol Section Abstract Doc Link 8949946 Disease Relevance 0 Pain Relevance 0.06
The number of splenic lymphocytes also decreased, whereas the percentage of lymphocytes expressing the CD4+ marker (T helper/inducer cells) modestly increased.
Gene_expression (expressing) of CD4 in lymphocytes
2) Confidence 0.78 Published 1996 Journal Anesthesiology Section Body Doc Link 8712452 Disease Relevance 0 Pain Relevance 0
However, no significant differences in systemic CD4/CD8 ratio or peritoneal or systemic CD25 expression were found between the different operative groups.
Gene_expression (expression) of CD4
3) Confidence 0.77 Published 2001 Journal Int J Colorectal Dis Section Abstract Doc Link 11515680 Disease Relevance 0.24 Pain Relevance 0.09
We investigated CD25, CD4, CD8 expression and CD4/CD8 ratio of systemic and peritoneal T lymphocytes in a rat model.
Spec (investigated) Gene_expression (expression) of CD4 in T lymphocytes
4) Confidence 0.77 Published 2001 Journal Int J Colorectal Dis Section Abstract Doc Link 11515680 Disease Relevance 0.27 Pain Relevance 0.08
Phenotypic expression of cell surface markers of T lymphocyte subsets (CD3+, CD3+ CD4+, CD3+ CD8+, and CD4+ / CD8+ ) and NK cell ( CD161+) in the spleen were analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expression) of CD4 in spleen
5) Confidence 0.72 Published 2005 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 15898424 Disease Relevance 0.06 Pain Relevance 0
Phenotypic expression of cell surface markers of T lymphocyte subsets (CD3+, CD3+ CD4+, CD3+ CD8+, and CD4+ / CD8+ ) and NK cell ( CD161+) in the spleen were analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expression) of CD4 in spleen
6) Confidence 0.72 Published 2005 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 15898424 Disease Relevance 0.06 Pain Relevance 0
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray (PAG), on splenic natural killer (NK) cell and lymphocyte functions, interleukin-2 (IL-2) production, expression of T cell (CD3), T helper cell (CD4), T suppressor cell (CD8), and NK cell (NKR-P1) surface markers, and expression of IL-2 (CD25) and transferrin (CD71) receptors.
Gene_expression (expression) of CD4 in mesencephalon associated with central grey and morphine
7) Confidence 0.64 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.43 Pain Relevance 0.57
Furthermore, morphine did not alter the expression of CD3, CD4, CD8, and NKR-P1 surface markers, but significantly (p < 0.001) downregulated the expression of CD25 and CD71 receptors following in vitro activation.
Gene_expression (expression) of CD4 in CD3 associated with morphine
8) Confidence 0.64 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.39 Pain Relevance 0.71
The median CD4 count among ?
Gene_expression (count) of CD4
9) Confidence 0.63 Published 2010 Journal AIDS Res Ther Section Abstract Doc Link PMC3022663 Disease Relevance 0.69 Pain Relevance 0
We assessed CD4 count at initial presentation for HIV care among ?
Gene_expression (count) of CD4 associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.63 Published 2010 Journal AIDS Res Ther Section Abstract Doc Link PMC3022663 Disease Relevance 0.46 Pain Relevance 0
In the multivariate analyses, the estimated annual change in CD4 count from 1997 to 2007 was higher among ?
Gene_expression (count) of CD4
11) Confidence 0.63 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC3022663 Disease Relevance 0.41 Pain Relevance 0
The median CD4 count was consistently lower in the ?
Gene_expression (count) of CD4
12) Confidence 0.63 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC3022663 Disease Relevance 0.54 Pain Relevance 0
The proportion of individuals presenting with a CD4 ?
Gene_expression (presenting) of CD4
13) Confidence 0.63 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC3022663 Disease Relevance 0.77 Pain Relevance 0
The proportion of individuals at first presentation for HIV care who had a CD4 count ?
Gene_expression (count) of CD4 associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.63 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC3022663 Disease Relevance 0.48 Pain Relevance 0
CD4+ IL2R expression was higher in the blood, but not in the spleen, in LAP vs OP animals (p = 0.02).
Gene_expression (expression) of CD4 in spleen
15) Confidence 0.62 Published 1998 Journal Surg Endosc Section Body Doc Link 9502703 Disease Relevance 0 Pain Relevance 0
Concomitant administration of SP with the non-peptide Neurokinin-1 receptor (NK1R) antagonist SR140333 completely inhibited the SP-mediated augmentation of Con A-induced PBL proliferation and IL-2 production as well as of CD4+ CD25+ and CD4+ RT1B+ T cell numbers in normal and capsaicin-treated rats.
Gene_expression (production) of CD4 in T cell associated with qutenza, antagonist and substance p
16) Confidence 0.62 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378865 Disease Relevance 0 Pain Relevance 0.85
Concomitant administration of SP with the non-peptide Neurokinin-1 receptor (NK1R) antagonist SR140333 completely inhibited the SP-mediated augmentation of Con A-induced PBL proliferation and IL-2 production as well as of CD4+ CD25+ and CD4+ RT1B+ T cell numbers in normal and capsaicin-treated rats.
Gene_expression (production) of CD4 in T cell associated with qutenza, antagonist and substance p
17) Confidence 0.62 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378865 Disease Relevance 0 Pain Relevance 0.85
First, both prophylaxis and treatment were used mainly in patients with CD4 cell counts less than 200 cells per ?
Gene_expression (counts) of CD4
18) Confidence 0.61 Published 2009 Journal Lancet Section Body Doc Link PMC2670965 Disease Relevance 0.63 Pain Relevance 0
The clear disadvantages of delaying initiation of treatment until CD4 count is below 200 cells per ?
Gene_expression (count) of CD4
19) Confidence 0.61 Published 2009 Journal Lancet Section Body Doc Link PMC2670965 Disease Relevance 0.36 Pain Relevance 0
Phenotypic expressions of cell surface markers of T lymphocyte subsets (CD3+, CD3+ CD4+, CD3+ CD8+, and CD4+/ CD8+) and NK cell(CD161+) in the spleen were analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expressions) of CD4 in spleen
20) Confidence 0.60 Published 2008 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18544843 Disease Relevance 0 Pain Relevance 0

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