INT52907

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Context Info
Confidence 0.34
First Reported 1994
Last Reported 2010
Negated 6
Speculated 3
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 5.94
Pain Relevance 5.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA)
plasma membrane (HLA-DRA) lysosome (HLA-DRA)
Anatomy Link Frequency
monocyte 34
CD86 4
epithelial cells 3
macrophage 2
pituitary 2
HLA-DRA (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 12 100.00 Very High Very High Very High
Enkephalin 63 99.44 Very High Very High Very High
substance P 63 99.12 Very High Very High Very High
agonist 22 98.66 Very High Very High Very High
Inflammation 324 97.88 Very High Very High Very High
anesthesia 361 96.76 Very High Very High Very High
antagonist 84 96.00 Very High Very High Very High
cytokine 102 95.56 Very High Very High Very High
cva 63 94.88 High High
Pain 25 94.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 397 97.88 Very High Very High Very High
Duodenal Ulcer 2 97.80 Very High Very High Very High
Corneal Disease 4 97.28 Very High Very High Very High
Cv General 3 Under Development 63 94.88 High High
Pain 25 94.76 High High
Sepsis 147 93.76 High High
Stress 107 93.12 High High
Hypersensitivity 27 88.60 High High
Injury 111 87.16 High High
Infection 179 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured plasma levels of cortisol and IL-10 in AAS and CAS patients in order to investigate their possible relationship with the modulation of HLA-DR expression on both CD14 monocyte subpopulations.
Spec (investigate) Regulation (modulation) of Gene_expression (expression) of HLA-DR in monocyte
1) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.08 Pain Relevance 0.23
In agreement with our in vivo observations, we showed that hydrocortisone was able to down-regulate HLA-DR expression on both monocyte subpopulations, whereas IL-10 only acted on CD14HIGH monocytes.
Regulation (regulate) of Gene_expression (expression) of HLA-DR in monocyte
2) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.05 Pain Relevance 0.09
Hydrocortisone (HC) down-regulated HLA-DR expression on both monocyte subpopulations, and the effect of HC was inhibited by the glucocorticoid receptor antagonist RU486 (Figure 5).
Regulation (regulated) of Gene_expression (expression) of HLA-DR in monocyte associated with antagonist
3) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.08 Pain Relevance 0.25
In contrast, the expression of HLA-DR on CD14LOW cells did not change at T4, and was only reduced at POD1 (-40%) and POD2 (-51%) (Figure 3B).
Neg (not) Regulation (change) of Gene_expression (expression) of HLA-DR
4) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.07 Pain Relevance 0.46
A significantly negative correlation between IL-10 levels and the alteration of HLA-DR expression could be obtained for CD14HIGH monocytes (r = -0.465, P = 0.039, when comparing T1 and T4, and r = -0.516, P = 0.030, when comparing T1 and POD1), but not for CD14LOW monocytes.


Regulation (alteration) of Gene_expression (expression) of HLA-DR in monocytes associated with anesthesia
5) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.07 Pain Relevance 0.31
Healthy volunteers were recruited (ICaReB) in order to determine the main mediators responsible for the down-regulation of HLA-DR expression on CD14HIGH and CD14LOW monocyte subpopulations (n = 9, three males and six females; age 37 ± 5 years).
Regulation (regulation) of Gene_expression (expression) of HLA-DR in monocyte
6) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.51
However, none of the tested neuromediators (norepinephrine, acetylcholine, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, substance P, and enkephalin) alone or together had any effect on HLA-DR expression (Figure 6).
Regulation (effect) of Gene_expression (expression) of HLA-DR in pituitary associated with enkephalin and substance p
7) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.26
We therefore decided to investigate the modification of HLA-DR expression on CD14HIGH and CD14LOW cells of patients undergoing severe surgery.
Spec (investigate) Regulation (modification) of Spec (investigate) Gene_expression (expression) of HLA-DR
8) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.50 Pain Relevance 0.03
A negative correlation between the percent change in the levels of plasma cortisol and the percent change in HLA-DR expression on CD14HIGH and CD14LOW monocytes was observed when comparing values obtained at T1 and POD1 (Figure 4).
Regulation (change) of Gene_expression (expression) of HLA-DR in monocytes associated with anesthesia
9) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.06 Pain Relevance 0.29
Thus, the relationship between changes in HLA-DR expression and IL-10 levels could only be analyzed in AAS patients.
Regulation (changes) of Gene_expression (expression) of HLA-DR
10) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.37
Relationship between plasma levels of cortisol or IL-10, and the modulation of HLA-DR expression on CD14HIGH and CD14LOW monocytes
Regulation (modulation) of Gene_expression (expression) of HLA-DR in monocytes
11) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.30
Thus, we studied the capacity of several microbial products, including agonists of TLR2, TLR4 or NOD2 (Pam3CysSK4, LPS and MDP, respectively), to modulate the expression of HLA-DR on monocytes.
Regulation (modulate) of Gene_expression (expression) of HLA-DR in monocytes associated with agonist
12) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.23
The effects of local anesthetics on monocyte mCD14 and HLA-DR expression were measured by dual monoclonal antibody staining and flow cytometry.
Regulation (effects) of Gene_expression (expression) of HLA-DR in monocyte associated with local anesthetic
13) Confidence 0.34 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.30 Pain Relevance 0.89
No influence of TEB on IL-6 levels, monocyte capacity to ex vivo release TNF-alpha upon LPS stimulation or their expression of HLA-DR was found.
Neg (No) Regulation (influence) of Gene_expression (expression) of HLA-DR in monocyte
14) Confidence 0.32 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.43 Pain Relevance 0.46
[The influence of laparoscopic cholecystectomy vs laparotomy on the monocyte antigen expression (HLA-DR)].
Regulation (influence) of Gene_expression (expression) of HLA-DR in monocyte
15) Confidence 0.26 Published 1998 Journal Ann Ital Chir Section Title Doc Link 10052213 Disease Relevance 0.12 Pain Relevance 0.06
IL-10 down-regulated HLA-DR expression on CD14HIGH monocytes, but not on CD14LOW cells (Figure 5).
Regulation (regulated) of Gene_expression (expression) of HLA-DR in monocytes
16) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.23
Accordingly, we tested the capacity of IL-10 and glucocorticoids to down-regulate the expression of HLA-DR on either sub-population from healthy controls.
Regulation (regulate) of Gene_expression (expression) of HLA-DR
17) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.03
HLA-DR expression before surgery in AAS and CAS patients was not significantly different from that measured in healthy volunteers.
Neg (not) Regulation (different) of Gene_expression (expression) of HLA-DR
18) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.36 Pain Relevance 0.33
While it was already known that both mediators down-regulated the expression of HLA-DR on monocytes [21,44-46], their specific effects on monocyte subpopulation was not investigated.
Regulation (regulated) of Gene_expression (expression) of HLA-DR in monocyte
19) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.03
We show for the first time that the expression of HLA-DR on the two monocyte subpopulations was not similarly down-regulated after a stressful situation such as an abdominal aortic surgery.
Neg (not) Regulation (regulated) of Gene_expression (expression) of HLA-DR in monocyte
20) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.85 Pain Relevance 0.25

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