INT52911

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 14
Disease Relevance 2.24
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tyms) methyltransferase activity (Tyms) aging (Tyms)
mRNA binding (Tyms) nucleolus (Tyms) nucleus (Tyms)
Anatomy Link Frequency
dorsal 1
brain 1
lamina 1
synapses 1
dorsal horns 1
Tyms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 20 99.84 Very High Very High Very High
Glutamate 10 99.70 Very High Very High Very High
opioid receptor 8 99.20 Very High Very High Very High
primary afferent fibers 25 99.12 Very High Very High Very High
dorsal rhizotomy 5 97.80 Very High Very High Very High
Potency 2 93.28 High High
unmyelinated 10 85.04 High High
Morphine 4 80.00 Quite High
Enkephalin 6 74.16 Quite High
Opioid 4 48.88 Quite Low
Disease Link Frequency Relevance Heat
Nociception 15 98.96 Very High Very High Very High
Colon Cancer 7 96.00 Very High Very High Very High
Congenital Anomalies 10 95.00 High High
Hematological Disease 10 89.68 High High
Trematode Infection 1 80.00 Quite High
Cholangiocarcinoma 5 78.48 Quite High
Disease 6 71.68 Quite High
Disorder Of Lipid Metabolism 5 50.32 Quite High
Lower Respiratory Tract Infection 5 41.44 Quite Low
Body Weight 25 14.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bromodeoxyuridine-immunoreactive (S-phase) cells and mRNA expression levels of thymidylate synthase and thymidine kinase in the prostate cells were markedly affected by the low-zinc diet.


Gene_expression (levels) of thymidylate synthase
1) Confidence 0.42 Published 2008 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2397411 Disease Relevance 0.16 Pain Relevance 0
The mRNA expression levels of prostatic thymidylate synthase (p < 0.05) and thymidine kinase (p < 0.01) were markedly reduced to 50% of the normal control by the low-zinc diet (Fig. 2).


Gene_expression (expression) of prostatic thymidylate synthase
2) Confidence 0.42 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.12 Pain Relevance 0
Bromodeoxyuridine-immunoreactive (S-phase) cells and mRNA expression levels of thymidylate synthase and thymidine kinase in the prostate cells were markedly affected by the low-zinc diet.


Gene_expression (expression) of thymidylate synthase
3) Confidence 0.42 Published 2008 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2397411 Disease Relevance 0.16 Pain Relevance 0
Down regulation by a low-zinc diet in gene expression of rat prostatic thymidylate synthase and thymidine kinase

Background

Gene_expression (expression) of prostatic thymidylate synthase
4) Confidence 0.37 Published 2008 Journal Nutr Metab (Lond) Section Title Doc Link PMC2397411 Disease Relevance 0.17 Pain Relevance 0
The levels of bromodeoxyuridine incorporated into the prostatic DNA and the mRNA expression levels of prostate thymidylate synthase and thymidine kinase were examined.


Spec (examined) Gene_expression (expression) of thymidylate synthase
5) Confidence 0.37 Published 2008 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2397411 Disease Relevance 0.18 Pain Relevance 0
Membranes were prepared from COS-7 cells transiently expressing TS11 bound [3H]diprenorphine with high affinity (KD = 0.23 +/- 0.04 nM).
Gene_expression (expressing) of TS11
6) Confidence 0.05 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7798908 Disease Relevance 0 Pain Relevance 0.40
We have cloned and expressed a rat brain cDNA, TS11, that encodes a mu-opioid receptor based on pharmacological, physiological, and anatomical criteria.
Gene_expression (expressed) of TS11 in brain associated with opioid receptor
7) Confidence 0.04 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7798908 Disease Relevance 0 Pain Relevance 0.31
For instance, patients overexpressing epidermal growth factor receptor and p53 with thymidylate synthase have a worse prognosis.
Gene_expression (overexpressing) of thymidylate synthase
8) Confidence 0.02 Published 2002 Journal Semin. Oncol. Section Abstract Doc Link 12422306 Disease Relevance 0.42 Pain Relevance 0
The dual immunofluorescence histochemistry indicated expression of VGluTs in substance P (SP)-containing axon terminals in lamina I and the outer part of lamina II.
Gene_expression (expression) of VGluTs in lamina associated with substance p
9) Confidence 0.01 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12541308 Disease Relevance 0.15 Pain Relevance 0.45
Electron microscopy confirmed the coexpression of VGluTs and SP in axon terminals within laminae I and II; VGluTs was associated with round synaptic vesicles at the asymmetric synapses.
Gene_expression (coexpression) of VGluTs in synapses associated with substance p
10) Confidence 0.01 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12541308 Disease Relevance 0.14 Pain Relevance 0.53
We examined immunohistochemically whether the vesicular glutamate transporters (VGluTs), VGluT1 and VGluT2, might be expressed in synaptic terminals of nociceptive primary afferent fibers within laminae I and II of the medullary and spinal dorsal horns of the rat.
Gene_expression (expressed) of VGluTs in dorsal horns associated with nociception, glutamate and primary afferent fibers
11) Confidence 0.01 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12541308 Disease Relevance 0.17 Pain Relevance 0.23
Expression of VGluTs in axon terminals of primary afferent fibers terminating in laminae I and II was also confirmed immunohistochemically after unilateral dorsal rhizotomy.
Gene_expression (Expression) of VGluTs in dorsal associated with dorsal rhizotomy and primary afferent fibers
12) Confidence 0.01 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12541308 Disease Relevance 0.16 Pain Relevance 0.40
Expression of VGluTs in synaptic terminals was confirmed by dual immunofluorescence histochemistry for VGluTs and synaptophysin.
Gene_expression (Expression) of VGluTs
13) Confidence 0.01 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12541308 Disease Relevance 0.16 Pain Relevance 0.35
The expression of the TS gene tended to be increased but the fold change was not significantly different from their parental cell lines.
Gene_expression (expression) of TS gene
14) Confidence 0.00 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.24 Pain Relevance 0

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