INT52912

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Context Info
Confidence 0.46
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.78
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tyms) methyltransferase activity (Tyms) aging (Tyms)
mRNA binding (Tyms) nucleolus (Tyms) nucleus (Tyms)
Anatomy Link Frequency
brain 1
synapses 1
Tyms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 4 99.12 Very High Very High Very High
opioid receptor 4 94.76 High High
Potency 1 93.76 High High
unmyelinated 2 90.80 High High
dorsal rhizotomy 1 89.04 High High
primary afferent fibers 5 84.76 Quite High
Morphine 2 80.48 Quite High
palliative 2 75.00 Quite High
Glutamate 2 75.00 Quite High
Enkephalin 3 74.64 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 16 96.48 Very High Very High Very High
Cancer 13 87.16 High High
Nociception 3 75.00 Quite High
Gastrointestinal Neoplasms 1 75.00 Quite High
Toxicity 24 5.00 Very Low Very Low Very Low
Diarrhoea 21 5.00 Very Low Very Low Very Low
Metastasis 13 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Vomiting 11 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gemcitabine acts synergistically with fluoropyrimidines to enhance the binding of thymidylate synthase and increase inhibition of DNA synthesis.
thymidylate synthase Binding (binding) of
1) Confidence 0.46 Published 2009 Journal Expert Opin Investig Drugs Section Abstract Doc Link 19678797 Disease Relevance 0.34 Pain Relevance 0.07
In conclusion, (-)-[11C]OMV exhibited appropriate brain kinetics during the time frame of 11C-labeled tracers and bound mainly to VAChTs; however, the binding to sigmal receptors was not disregarded.
VAChTs Binding (bound) of in brain
2) Confidence 0.04 Published 2006 Journal Ann Nucl Med Section Abstract Doc Link 16922470 Disease Relevance 0 Pain Relevance 0.14
Membranes were prepared from COS-7 cells transiently expressing TS11 bound [3H]diprenorphine with high affinity (KD = 0.23 +/- 0.04 nM).
TS11 Binding (bound) of
3) Confidence 0.03 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7798908 Disease Relevance 0 Pain Relevance 0.41
Of these treatments, fluoropyrimidines are the most often used and best investigated drugs [2,3]. 5-Fluorouracil (5-FU)-based chemotherapy, – usually biomodulated with folinic acid (FA) to increase its affinity for thymidylate synthase [4] -, was associated with an approximate doubling of the median survival compared to routine standard of care [5].
thymidylate synthase Binding (affinity) of
4) Confidence 0.01 Published 2004 Journal BMC Cancer Section Body Doc Link PMC497044 Disease Relevance 0.30 Pain Relevance 0
Electron microscopy confirmed the coexpression of VGluTs and SP in axon terminals within laminae I and II; VGluTs was associated with round synaptic vesicles at the asymmetric synapses.
VGluTs Binding (associated) of in synapses associated with substance p
5) Confidence 0.01 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12541308 Disease Relevance 0.14 Pain Relevance 0.54

General Comments

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