INT52916

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Context Info
Confidence 0.54
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.40
Pain Relevance 10.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkca) mitochondrion (Prkca) aging (Prkca)
endoplasmic reticulum (Prkca) plasma membrane (Prkca) nucleus (Prkca)
Anatomy Link Frequency
frontal cortex 3
muscle 1
brain 1
PVN 1
Prkca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 54 100.00 Very High Very High Very High
agonist 26 99.56 Very High Very High Very High
Morphine 39 99.34 Very High Very High Very High
fortral 12 99.12 Very High Very High Very High
narcan 23 99.04 Very High Very High Very High
methadone 9 98.98 Very High Very High Very High
Enkephalin 6 98.74 Very High Very High Very High
opioid receptor 4 98.56 Very High Very High Very High
opiate 30 98.28 Very High Very High Very High
antagonist 5 97.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 99.78 Very High Very High Very High
Toxocariasis 5 99.20 Very High Very High Very High
Overdose 4 98.64 Very High Very High Very High
Myalgia 1 95.88 Very High Very High Very High
Temporomandibular Joint Disorders 1 94.60 High High
Hypersensitivity 5 94.52 High High
Opiate Addiction 7 93.84 High High
Attention Deficit Hyperactivity Disorder 1 67.88 Quite High
Hyperalgesia 1 41.60 Quite Low
Nociception 1 39.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute (2 h) and chronic treatment (5 days) with other mu-agonists heroin (30 mg/kg and 10 to 30 mg/kg) and methadone (30 mg/kg and 5 to 30 mg/kg) also induced similar decreases of PKC-alphabeta (acute: 25% and 23%; chronic: 28% and 18%).
Negative_regulation (decreases) of PKC-alphabeta associated with agonist and methadone
1) Confidence 0.54 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9109366 Disease Relevance 0 Pain Relevance 1.14
Chronic (5 days) treatment with pentazocine (10 to 80 mg/kg), but not spiradoline (2 to 30 mg/kg), also induced a similar decrease of PKC-alphabeta (35%).
Negative_regulation (decrease) of PKC-alphabeta associated with fortral
2) Confidence 0.54 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9109366 Disease Relevance 0 Pain Relevance 1.64
Acute (2 h) treatments with pentazocine (80 mg/kg, mixed kappa/delta-agonist and mu-antagonist), spiradoline (30 mg/kg, selective kappa-agonist) and [D-Pen2, D-Pen5] enkephalin (14 nmol i.c.v., selective delta-agonist) induced significant decreases of PKC-alphabeta (19-33%).
Negative_regulation (decreases) of PKC-alphabeta associated with fortral, antagonist, agonist and enkephalin
3) Confidence 0.54 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9109366 Disease Relevance 0 Pain Relevance 1.57
These results indicated that the decrease of brain PKC-alpha beta induced by heroin/morphine is a mu-opioid receptor-mediated effect.
Negative_regulation (decrease) of PKC-alpha beta in brain associated with kinase c, opioid receptor and morphine
4) Confidence 0.42 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7798919 Disease Relevance 0.29 Pain Relevance 1.36
The loss of PKC-alpha beta in the brain of human addicts paralleled that observed in the frontal cortex of rats after chronic treatment with morphine (10-100 mg/kg i.p. for 5 days) (PKC-alpha beta decreased by 34%, p < 0.05).
Negative_regulation (loss) of PKC-alpha beta in frontal cortex associated with kinase c, urological neuroanatomy and morphine
5) Confidence 0.42 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7798919 Disease Relevance 0.37 Pain Relevance 0.99
The loss of PKC-alpha beta in the brain of human addicts paralleled that observed in the frontal cortex of rats after chronic treatment with morphine (10-100 mg/kg i.p. for 5 days) (PKC-alpha beta decreased by 34%, p < 0.05).
Negative_regulation (decreased) of PKC-alpha beta in frontal cortex associated with kinase c, urological neuroanatomy and morphine
6) Confidence 0.31 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7798919 Disease Relevance 0.35 Pain Relevance 1.13
In the frontal cortex, a marked decrease (53%, p < 0.05) in the immunoreactivity of PKC-alpha beta was found in heroin addicts compared with matched controls.
Negative_regulation (decrease) of PKC-alpha beta in frontal cortex associated with kinase c and urological neuroanatomy
7) Confidence 0.31 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7798919 Disease Relevance 0.38 Pain Relevance 0.89
The protein levels of PKCalpha and gamma were significantly down-regulated in the PVN and NTS/VLM from the morphine-withdrawn rats.
Negative_regulation (down-regulated) of PKCalpha in PVN associated with toxocariasis and morphine
8) Confidence 0.12 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16190878 Disease Relevance 0.49 Pain Relevance 1.54
Thus, selective targeting of peripheral mGluR 5 and PKCalpha, as well as PKCepsilon, might serve as an effective therapeutic strategy in the management of chronic muscle pain conditions, such as temporomandibular disorders.
Negative_regulation (targeting) of PKCalpha in muscle associated with pain, myofascial pain syndrome and myalgia
9) Confidence 0.03 Published 2007 Journal Neuroscience Section Abstract Doc Link 17306466 Disease Relevance 0.52 Pain Relevance 0.51

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