INT52924

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 49
Total Number 49
Disease Relevance 28.08
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
Anatomy Link Frequency
erythrocyte 2
plasma 1
chondrocytes 1
facets 1
nucleus 1
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 11 100.00 Very High Very High Very High
Paracetamol 196 99.98 Very High Very High Very High
cytokine 172 99.82 Very High Very High Very High
rheumatoid arthritis 170 99.44 Very High Very High Very High
Inflammation 328 99.28 Very High Very High Very High
Hippocampus 44 99.20 Very High Very High Very High
aspirin 179 98.84 Very High Very High Very High
ischemia 56 98.68 Very High Very High Very High
antidepressant 32 98.64 Very High Very High Very High
dexamethasone 42 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 253 100.00 Very High Very High Very High
Sepsis 266 99.84 Very High Very High Very High
Manic Depressive Disorder 34 99.74 Very High Very High Very High
Myoma 21 99.72 Very High Very High Very High
Diabetes Mellitus 318 99.60 Very High Very High Very High
Cataract 357 99.58 Very High Very High Very High
Polyps 24 99.52 Very High Very High Very High
Nephrotoxicity 45 99.50 Very High Very High Very High
Rheumatoid Arthritis 170 99.44 Very High Very High Very High
Prostate Cancer 3 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Our findings bring insight into the differential effects of NSAID on the GR system and may provide an explanation for the reduced level of GR found in OA chondrocytes.
Negative_regulation (reduced) of GR in chondrocytes
1) Confidence 0.58 Published 1994 Journal J. Rheumatol. Section Body Doc Link 7799361 Disease Relevance 0 Pain Relevance 0
RESULTS: Naproxen and indomethacin but not tiaprofenic acid, at therapeutic concentrations, significantly reduced the level of GR in synovial cells.
Negative_regulation (reduced) of GR in synovial cells
2) Confidence 0.58 Published 1994 Journal J. Rheumatol. Section Body Doc Link 7799361 Disease Relevance 0 Pain Relevance 0
Such tests are more sensitive as they assess facets of the HPA axis which are considered to be primary causal factors, namely dysregulation of hypothalamic drive (Holsboer 2002) and reduced glucocorticoid receptor (GR) feedback (McQuade and Young 2000; Pariante and Miller 2001).
Negative_regulation (reduced) of GR in facets
3) Confidence 0.56 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.53 Pain Relevance 0.13
Interestingly, first-degree relatives of patients with bipolar disorder also showed GR-alpha mRNA reduction (Matsubara et al 2006).
Negative_regulation (reduction) of GR associated with manic depressive disorder
4) Confidence 0.41 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 1.12 Pain Relevance 0
The greater cortisol response and by implication the reduced GR mediated feedback inhibition in patients with a positive family history (in both the high and low emotional neglect groups) suggests that genetic factors may underlie this neuroendocrine finding.
Negative_regulation (inhibition) of GR
5) Confidence 0.41 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.30 Pain Relevance 0
-estradiol in the blood is measured in minutes, the comparatively small decrease in hormone levels in Gr.E/P was unexpected.
Negative_regulation (decrease) of Gr in blood
6) Confidence 0.39 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2848231 Disease Relevance 0.20 Pain Relevance 0.03
When insulin concentrations were matched during a second hyperglycemic pancreatic clamp protocol, fructose administration was associated with an 11.1 micromol. kg(-1). min(-1) increase in TGO, a 7.8 micromol. kg(-1). min(-1) increase in NEGP, a 2.2 micromol. kg(-1). min(-1) increase in GC, and a 7.2 micromol. kg(-1). min(-1) decrease in GR(d) (P < 0. 05).
Negative_regulation (decrease) of GR
7) Confidence 0.39 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11001775 Disease Relevance 0.08 Pain Relevance 0.08
Compared to patients with polyps and myoma, significant elevation of GR activity was recorded in all examined groups, hyperplasia simplex (108%, p < 0.05), hyperplasia complex (94%, p < 0.05) and adenocarcinoma (120%, p < 0.05).
Negative_regulation (elevation) of GR associated with adenocarcinoma, polyps, hyperplasia and myoma
8) Confidence 0.35 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 2.20 Pain Relevance 0
Most of the studies showing GR downregulation also found decreased cytosolic GR binding, which may result from compartmentalization of the GR during the acute response to cytokines.
Negative_regulation (downregulation) of GR associated with cytokine
9) Confidence 0.33 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.83 Pain Relevance 0.25
Some studies found downregulation of GR [53,65-67] and others found upregulation [68-70].
Negative_regulation (downregulation) of GR
10) Confidence 0.33 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 1.09 Pain Relevance 0.21
Potential mechanisms for cytokine-induced reduction in GR function and affinity may include inhibition of GR translocation from cytoplasm to nucleus and reduction in GR-mediated gene transcription [68].
Negative_regulation (reduction) of GR in nucleus associated with cytokine
11) Confidence 0.33 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.68 Pain Relevance 0.19
In addition, studies conducted in cells treated with IL-1 for 24–48 hours or in tissues from animals with chronic sepsis or patients with chronic inflammation consistently showed GR upregulation [61,70,71], whereas experiments with shorter treatments with IL-1 inducers or conducted in the early phase of human sepsis showed GR downregulation [53,66,67].
Negative_regulation (downregulation) of GR associated with inflammation and sepsis
12) Confidence 0.33 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.86 Pain Relevance 0.25
A similar reduction in GR function and affinity for ligand can be demonstrated on peripheral cells and tissues from patients with inflammatory diseases such as asthma, ulcerative colitis, AIDS, rheumatoid arthritis, acute respiratory distress syndrome and sepsis [56-64].
Negative_regulation (reduction) of GR in respiratory associated with asthma, inflammatory bowel disease, inflammation, acquired immune deficiency syndrome or hiv infection, rheumatoid arthritis, adult respiratory distress syndrome, disease and sepsis
13) Confidence 0.33 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.92 Pain Relevance 0.21
Inhibitory effects of some analgesic and anaesthetic drugs on human erythrocyte glutathione reductase were investigated.
Negative_regulation (effects) of erythrocyte glutathione reductase in erythrocyte associated with analgesic
14) Confidence 0.31 Published 2009 Journal J Enzyme Inhib Med Chem Section Abstract Doc Link 18608753 Disease Relevance 0 Pain Relevance 0.27
NIM and NAP did not influence cellular GR protein levels or nucleocytoplasmic shuttling, although DEX lowered GR messenger RNA and protein levels after 48 hours.
Negative_regulation (lowered) of GR
15) Confidence 0.30 Published 1999 Journal Arthritis Rheum. Section Body Doc Link 9920026 Disease Relevance 0 Pain Relevance 0
Both endotoxin and lipopolysaccaride (LPS) have been shown to decrease GR affinity for ligand, mainly by inducing cytokine expression [53].
Negative_regulation (decrease) of GR associated with cytokine
16) Confidence 0.24 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.82 Pain Relevance 0.25
-induced blockade of GR transactivation by binding to nuclear receptor binding domain of GR-interacting protein 1.
Negative_regulation (blockade) of GR
17) Confidence 0.24 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.20 Pain Relevance 0.12
functions as a dominant negative inhibitor of GR?
Negative_regulation (inhibitor) of GR
18) Confidence 0.22 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.51 Pain Relevance 0.12
Most of the studies showing GR downregulation also found decreased cytosolic GR binding, which may result from compartmentalization of the GR during the acute response to cytokines.
Negative_regulation (decreased) of GR associated with cytokine
19) Confidence 0.21 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.81 Pain Relevance 0.25
Specifically, the reduced UA/Gr ratio was nearly normalized after 4 weeks of antipsychotic treatment.
Negative_regulation (reduced) of Gr
20) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2831068 Disease Relevance 0.13 Pain Relevance 0

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