INT52937

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 7
Speculated 0
Reported most in Abstract
Documents 37
Total Number 37
Disease Relevance 31.33
Pain Relevance 7.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 5
T cells 2
smooth muscle 1
stellate cells 1
bone marrow 1
Cd68 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 243 99.66 Very High Very High Very High
Spinal cord 19 99.36 Very High Very High Very High
Inflammatory response 21 99.34 Very High Very High Very High
Eae 14 98.12 Very High Very High Very High
Sciatic nerve 39 98.10 Very High Very High Very High
allodynia 7 97.48 Very High Very High Very High
tolerance 16 97.26 Very High Very High Very High
Neuritis 10 96.64 Very High Very High Very High
Pain 47 96.40 Very High Very High Very High
Thermal hyperalgesia 3 93.76 High High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 9 100.00 Very High Very High Very High
Urological Neuroanatomy 2 100.00 Very High Very High Very High
Cancer 65 99.76 Very High Very High Very High
INFLAMMATION 262 99.66 Very High Very High Very High
Rhinitis 10 99.40 Very High Very High Very High
Disease 130 98.72 Very High Very High Very High
Uveitis 42 98.48 Very High Very High Very High
Injury 40 98.12 Very High Very High Very High
Pulmonary Disease 219 98.10 Very High Very High Very High
Syndrome 14 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The infiltrating cells were predominantly CD68 positive monocyte/macrophages, which is different from what is found in Sjögren's syndrome.
Gene_expression (monocyte/macrophages) of CD68 in macrophages associated with syndrome
1) Confidence 0.67 Published 1994 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 7801139 Disease Relevance 0.97 Pain Relevance 0.08
Double staining revealed that almost all P2X(4)R(+) cells co-expressed CD68, a marker for reactive microglia, but not the astrocyte marker, glial fibrillary acidic protein (GFAP).
Gene_expression (expressed) of CD68 in astrocyte
2) Confidence 0.63 Published 2008 Journal Neuroscience Section Abstract Doc Link 18276080 Disease Relevance 1.23 Pain Relevance 1.51
These cells expressed the CD68 histiocytic marker.
Gene_expression (expressed) of CD68
3) Confidence 0.60 Published 2007 Journal Ann Pathol Section Abstract Doc Link 17568357 Disease Relevance 0.58 Pain Relevance 0.09
Autopsy revealed the proliferation of tumor cells within the splenic sinus and the liver sinusoids, which displayed extreme hemophagocytosis and strong expression of the histiocytic markers CD68 (KP1 and PG-M1) and CD163.
Gene_expression (expression) of CD68 in liver sinusoids associated with cancer
4) Confidence 0.60 Published 2008 Journal Int. J. Hematol. Section Abstract Doc Link 18224419 Disease Relevance 0.90 Pain Relevance 0.21
There were more invading MHC II+ macrophages lacking OX-42(CD11b)/CD4/ED1(CD68) after transection.
Neg (lacking) Gene_expression (lacking) of CD68 in macrophages
5) Confidence 0.58 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17187959 Disease Relevance 0.87 Pain Relevance 0.79
Immunohistochemically stained sections were counter-stained using either hematoxylin (CD68) or DAPI (Ki-67 and DCX), as appropriate.
Gene_expression (using) of CD68
6) Confidence 0.55 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2825515 Disease Relevance 0.09 Pain Relevance 0.10
The foam cells were positive for CD68 and negative for AE1/AE3.
Neg (negative) Gene_expression (positive) of CD68 in foam cells
7) Confidence 0.52 Published 2003 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14567739 Disease Relevance 0.44 Pain Relevance 0.17
The histiocytic cells were positive with S-100 protein and CD68.
Gene_expression (positive) of CD68
8) Confidence 0.50 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10370692 Disease Relevance 0.83 Pain Relevance 0.08
The induction of central tolerance with intrathymic HUVEC-injection and the immunomodulatory strategy using pristane attenuated the expression of caspase-3 as well as the expression of CD68 and CD19.


Gene_expression (expression) of CD68 associated with tolerance
9) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.14 Pain Relevance 0.08
Compared to controls, CD68, MCA967, and TCR alpha/beta expression was observed in corneas in rats with EIU.
Gene_expression (expression) of CD68 in corneas associated with uveitis
10) Confidence 0.43 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2435159 Disease Relevance 0.80 Pain Relevance 0.08
The tumor cells were immunoreactive for CD68, CD31, and CD4.
Gene_expression (immunoreactive) of CD68 associated with cancer
11) Confidence 0.34 Published 2005 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 16086090 Disease Relevance 1.32 Pain Relevance 0.08
Immunohistochemical studies, performed in 7 cases showed a mixture of CD68+ histiocytes and CD3+ T cells, with few B cells (CD20+) and few granulocytes.
Gene_expression (histiocytes) of CD68 in T cells
12) Confidence 0.33 Published 2009 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 19623033 Disease Relevance 1.27 Pain Relevance 0.21
Although pointing to a down-regulation of inflammation is the enhanced expression of CD68 a member of the family of neuroimmune regulatory proteins (NIRegs).
Gene_expression (expression) of CD68 associated with inflammation
13) Confidence 0.33 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.94 Pain Relevance 0.18
However, the expression of galanin, NPY; the satellite cell marker, GFAP and the macrophage marker, CD68, did increase in the DRG, all of which are features of models of nerve-lesion associated pain (Ma and Bisby, 1998; Wynick et al., 2001).
Gene_expression (expression) of CD68 in satellite cell associated with pain
14) Confidence 0.32 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.31 Pain Relevance 0.40
These giant cells expressed histiocytic markers CD68 and alpha(1)-antitrypsin but not c-Kit, a marker for GISTs.
Gene_expression (expressed) of CD68
15) Confidence 0.28 Published 2002 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 12171499 Disease Relevance 0.85 Pain Relevance 0.09
At days 3, 7 and 14 post application, we assessed the presence of macrophages in the HIV-1 gp120 treated sciatic nerve at the site of application as well as 1 cm proximally and 1 cm distally, using an antibody to CD68 (ED-1), a lysosomal protein expressed by activated tissue macrophages.
Gene_expression (expressed) of CD68 in sciatic nerve associated with acquired immune deficiency syndrome or hiv infection and sciatic nerve
16) Confidence 0.25 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.76 Pain Relevance 0.12
Immunohistochemically, the tumor cells were positive for vimentin, CD68, alpha-1-antichymotrypsin and alpha-1-antitrypsin.
Gene_expression (positive) of CD68 associated with cancer
17) Confidence 0.24 Published 2005 Journal J. Oral Pathol. Med. Section Abstract Doc Link 15689235 Disease Relevance 0.78 Pain Relevance 0.08
The infiltrating cells were predominantly CD68 positive monocyte/macrophages, which is different from what is found in Sjögren's syndrome.
Gene_expression (monocyte/macrophages) of CD68 in monocyte associated with syndrome
18) Confidence 0.23 Published 1994 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 7801139 Disease Relevance 0.97 Pain Relevance 0.08
In COPD, there is an abnormal inflammatory response, characterized by a predominance of CD8+ T-cells, CD68+ macrophages, and neutrophils in the conducting airways, lung parenchyma, and pulmonary vasculature (Soto and Hanania 2005; O’Donnell et al 2006; Wright and Churg 2006).
Gene_expression (macrophages) of CD68 in T-cells associated with inflammatory response and pulmonary disease
19) Confidence 0.23 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.40 Pain Relevance 0.48
In fact, the inflammatory response is abnormal, with CD8+ T-cells, CD68+ macrophages, and neutrophils predominating in the conducting airways, lung parenchyma, and pulmonary vasculature.
Gene_expression (macrophages) of CD68 in lung associated with inflammatory response
20) Confidence 0.23 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Abstract Doc Link PMC2699952 Disease Relevance 0.70 Pain Relevance 0.18

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