INT52952

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Context Info
Confidence 0.13
First Reported 1994
Last Reported 1999
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 3.57
Pain Relevance 4.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Pdpn) embryo development (Pdpn) cell proliferation (Pdpn)
signal transduction (Pdpn) cell adhesion (Pdpn) plasma membrane (Pdpn)
Anatomy Link Frequency
dorsal 2
Pdpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 13 99.52 Very High Very High Very High
Raphe 12 99.08 Very High Very High Very High
Opioid 6 98.84 Very High Very High Very High
Ventral tegmentum 8 98.56 Very High Very High Very High
imagery 4 97.76 Very High Very High Very High
Thalamus 12 97.72 Very High Very High Very High
agonist 6 97.68 Very High Very High Very High
Nucleus accumbens 8 97.52 Very High Very High Very High
opioid receptor 6 96.96 Very High Very High Very High
Substantia nigra 8 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Respiratory Tract Infection 59 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that [125I]RTI-55 binds to 5HTT in the former areas and to DAT in the latter areas.
RTI-55 Binding (binds) of associated with respiratory tract infection
1) Confidence 0.13 Published 1994 Journal J. Chem. Neuroanat. Section Abstract Doc Link 7802967 Disease Relevance 0.69 Pain Relevance 0.78
Further, in the presence of clomipramine, a selective ligand for 5HTT, [125I]RTI-55 binding was remarkably inhibited in the midline and lateral geniculate nuclei of the thalamus, the hypothalamic nuclei, the superior colliculus, the dorsal raphe nucleus, and the facial nucleus, while [125I]RTI-55 binding remained in the olfactory tubercle, the caudate putamen, the accumbens nucleus, the substantia nigra compact part, the subthalamic nucleus, and the ventral tegmental area.
RTI-55 Binding (binding) of in dorsal associated with ventral tegmentum, nucleus accumbens, respiratory tract infection, substantia nigra, thalamus and raphe
2) Confidence 0.13 Published 1994 Journal J. Chem. Neuroanat. Section Abstract Doc Link 7802967 Disease Relevance 0.62 Pain Relevance 0.63
Therefore, radiolabelled RTI-55, combined with unlabelled clomipramine, which displaces its binding to 5HTT, also appears to be suitable for the selective imaging of DAT in vivo.
RTI-55 Binding (binding) of associated with respiratory tract infection and imagery
3) Confidence 0.13 Published 1994 Journal J. Chem. Neuroanat. Section Abstract Doc Link 7802967 Disease Relevance 0.57 Pain Relevance 0.64
Further, in the presence of clomipramine, a selective ligand for 5HTT, [125I]RTI-55 binding was remarkably inhibited in the midline and lateral geniculate nuclei of the thalamus, the hypothalamic nuclei, the superior colliculus, the dorsal raphe nucleus, and the facial nucleus, while [125I]RTI-55 binding remained in the olfactory tubercle, the caudate putamen, the accumbens nucleus, the substantia nigra compact part, the subthalamic nucleus, and the ventral tegmental area.
RTI-55 Binding (binding) of in dorsal associated with ventral tegmentum, nucleus accumbens, respiratory tract infection, substantia nigra, thalamus and raphe
4) Confidence 0.13 Published 1994 Journal J. Chem. Neuroanat. Section Abstract Doc Link 7802967 Disease Relevance 0.63 Pain Relevance 0.77
In this study, the role of weak electrostatic and hydrogen-bonding "pi-pi" interactions of the O atom of the carbonyl group and the phenyl ring structures of RTI-4614-4 and its four enantiomers with residues Tyr148, Trp318, and His319 were explored via site-directed mutagenesis.
RTI-4614-4 Binding (interactions) of associated with respiratory tract infection
5) Confidence 0.11 Published 1999 Journal Synapse Section Abstract Doc Link 10188634 Disease Relevance 0.18 Pain Relevance 0.61
These data also show that the stereoisomers of RTI-4614-4 probably bind to different domains of the mu receptor and suggest that manipulation of stereochemistry may be a useful tool for designing domain-specific ligands.
RTI-4614-4 Binding (bind) of associated with respiratory tract infection
6) Confidence 0.06 Published 1998 Journal Synapse Section Abstract Doc Link 9450512 Disease Relevance 0.27 Pain Relevance 0.37
Viewed collectively, these data suggest that the region from the N terminal to the start of the TMH3 of the mu opioid receptor determines the binding affinity of RTI-4614-4 and its isomers and that the e3 loop also plays a major role in determining the binding affinity of mu agonist peptides.
RTI-4614-4 Binding (affinity) of associated with respiratory tract infection, agonist and mu opioid receptor
7) Confidence 0.06 Published 1998 Journal Synapse Section Abstract Doc Link 9450512 Disease Relevance 0.26 Pain Relevance 0.39
The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
RTI-4614-4 Binding (bind) of associated with respiratory tract infection and mu opioid receptor
8) Confidence 0.06 Published 1998 Journal Synapse Section Title Doc Link 9450512 Disease Relevance 0.18 Pain Relevance 0.30
To determine whether enantiomeric ligands can serve to distinguish between different binding pockets (which focuses the analysis on asymmetric structural factors while avoiding confounding changes in physiochemical characteristics), we analyzed the binding of the 3-methylfentanyl congeners RTI-4614-4 [(+/-)-cis-N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N- phenylpropanamide HCl)], its four stereoisomers [(2S,3R,4S)-1a, (2R,3R,4S)-1b, (2R,3S,4R)-1c, and (2S,3S,4R)-1d], and other mu agonists with cloned rat mu opioid receptors stably expressed in HEK-293 cells and mu/kappa receptor chimeras.
RTI-4614-4 Spec (analyzed) Binding (binding) of associated with respiratory tract infection, mu agonist and mu opioid receptor
9) Confidence 0.06 Published 1998 Journal Synapse Section Abstract Doc Link 9450512 Disease Relevance 0.17 Pain Relevance 0.29

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