INT5297

Context Info Confidence 0.56 First Reported 1984 Last Reported 2010 Negated 2 Speculated 1 Reported most in Abstract Documents 20 Total Number 21 Disease Relevance 10.81 Pain Relevance 5.13

extracellular space (IFNA2) extracellular region (IFNA2) cell-cell signaling (IFNA2)

Anatomy Link Frequency neurons 2 lung 1 optic nerves 1 oocytes 1 CNS 1 IFNA2 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 11 100.00 Paracetamol 8 100.00 Analgesic 6 100.00 Central nervous system 12 99.84 opioid receptor 7 99.56 opiate 7 99.28 Pain 6 98.94 cytokine 4 98.64 Inflammation 2 96.96 Opioid 4 96.08

Disease Link Frequency Relevance Heat Diabetic Nephropathy 4 100.00 Chronic Hepatitis 21 99.86 Cardiovascular Disorder Under Development 2 99.48 Metastasis 9 99.28 Myeloid Leukemia 2 99.12 Mental Disorders 2 98.76 Hypercalcemia 3 98.68 Toxicity 12 98.44 Fever 12 98.44 Schizophrenia 15 97.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Defective alpha-interferon (aIFN) regulation resulting in excessive effect is postulated to cause schizophrenia.

Regulation (regulation) of alpha-interferon associated with schizophrenia

1) Confidence 0.56 Published 1990 Journal J. Nerv. Ment. Dis. Section Abstract Doc Link 2246646 Disease Relevance 0.58 Pain Relevance 0.18

Defective alpha-interferon (aIFN) regulation resulting in excessive effect is postulated to cause schizophrenia.

Regulation (regulation) of aIFN associated with schizophrenia

2) Confidence 0.56 Published 1990 Journal J. Nerv. Ment. Dis. Section Abstract Doc Link 2246646 Disease Relevance 0.58 Pain Relevance 0.18

The effects of indomethacin, aspirin, and acetaminophen on the antiviral and antiproliferative activities of recombinant human interferon-alpha 2a (rIFN-alpha 2a) were studied in vitro.

Regulation (effects) of rIFN-alpha 2a associated with aspirin and paracetamol

3) Confidence 0.45 Published 1988 Journal J. Interferon Res. Section Abstract Doc Link 3230331 Disease Relevance 0.25 Pain Relevance 0.39

[Distinct structural bases of the immunoregulatory and central analgesic effects of IFNalpha].

Regulation (immunoregulatory) of IFNalpha associated with analgesic

4) Confidence 0.45 Published 2000 Journal Sheng Li Xue Bao Section Title Doc Link 11956564 Disease Relevance 0 Pain Relevance 0.76

In addition, there are many reports indicating that interferon-alpha (IFN-alpha) participates in the regulation of various cellular and humoral processes such as the endocrine system modulates behavior, brain activity, temperature, glucose sensitive neurons, feeding pattern and opiate activity.

Regulation (regulation) of interferon-alpha in neurons associated with opiate

5) Confidence 0.45 Published 1998 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 9600621 Disease Relevance 0.19 Pain Relevance 0.19

The present observations using the guinea-pig ileum preparation and cortical neurons recording failed to support the hypothesis that alpha-IFN effects are mediated via opiate receptors.

Neg (failed) Regulation (effects) of alpha-IFN in neurons associated with opiate

6) Confidence 0.44 Published 1984 Journal Life Sci. Section Abstract Doc Link 6088931 Disease Relevance 0.07 Pain Relevance 0.68

[Effect of pamidronate and interferon-alpha on bone and lung metastases and hypercalcemia in a patient with renal cell carcinoma].

Regulation ([Effect) of interferon-alpha in lung associated with renal cancer, hypercalcemia and metastasis

7) Confidence 0.42 Published 1996 Journal Hinyokika Kiyo Section Title Doc Link 8973939 Disease Relevance 0.99 Pain Relevance 0.08

[Multiple mononeuropathy during recombinant interferon-alpha 2a therapy for chronic hepatitis C].

Regulation (mononeuropathy) of interferon-alpha associated with chronic hepatitis and diabetic nephropathy

8) Confidence 0.39 Published 1992 Journal Rinsho Shinkeigaku Section Title Doc Link 1300264 Disease Relevance 0.81 Pain Relevance 0.29

The IFN-alpha-2b treatment significantly affected patients' physical condition, mental health, and social life.

Regulation (affected) of IFN-alpha-2b associated with mental disorders

9) Confidence 0.37 Published 2005 Journal Cancer Nurs Section Abstract Doc Link 15915059 Disease Relevance 0.89 Pain Relevance 0

The emotional state of the patients was more affected during IFN-alpha-2b treatment.

Regulation (affected) of IFN-alpha-2b

10) Confidence 0.37 Published 2005 Journal Cancer Nurs Section Abstract Doc Link 15915059 Disease Relevance 0.86 Pain Relevance 0

Effects of recombinant human alpha-interferon in a rodent cardiotoxicity model.

Regulation (Effects) of alpha-interferon associated with cardiovascular disorder under development

11) Confidence 0.36 Published 1990 Journal Toxicol. Lett. Section Title Doc Link 2296775 Disease Relevance 0.37 Pain Relevance 0.12

Effects of recombinant human alpha-interferon in a rodent cardiotoxicity model.

Regulation (Effects) of alpha-interferon associated with cardiovascular disorder under development

12) Confidence 0.36 Published 1990 Journal Toxicol. Lett. Section Title Doc Link 2296775 Disease Relevance 0.37 Pain Relevance 0.12

[Rheumatic manifestations of chronic hepatitis C and response to the treatment with interferon alpha-2b].

Regulation (response) of interferon alpha associated with pain and chronic hepatitis

13) Confidence 0.34 Published 1994 Journal Rev Rhum Ed Fr Section Title Doc Link 7833885 Disease Relevance 1.07 Pain Relevance 0.13

Interferon alpha therapy was effective against not only the CML but also the FMF.

Regulation (effective) of Interferon alpha associated with myeloid leukemia and fever

14) Confidence 0.29 Published 2004 Journal Int. J. Hematol. Section Abstract Doc Link 15168590 Disease Relevance 1.14 Pain Relevance 0.16

Meclomen at the same concentration range had no effect on the antiviral activity of human IFN alpha.

Neg (no) Regulation (effect) of IFN alpha

15) Confidence 0.26 Published 1990 Journal Acta Virol. Section Abstract Doc Link 1975722 Disease Relevance 0.18 Pain Relevance 0.17

Negative symptoms result from aIFN effects on CNS development and the behavioral toxicity of aIFN.

Regulation (effects) of aIFN in CNS associated with toxicity and central nervous system

16) Confidence 0.25 Published 1990 Journal J. Nerv. Ment. Dis. Section Abstract Doc Link 2246646 Disease Relevance 0.81 Pain Relevance 0.27

This story investigated the effects of interferon-alpha-2b (IFN-alpha2b) on the optic nerves of 17 adult male Wistar albino rats.

Spec (investigated) Regulation (effects) of IFN-alpha2b in optic nerves

17) Confidence 0.16 Published 2006 Journal Adv Ther Section Abstract Doc Link 16644604 Disease Relevance 0 Pain Relevance 0.07

The study of viral kinetics in patients with chronic hepatitis C who show sustained virologic response to interferon-alpha treatment has shown that the decline in viral RNA follows at least two phases, where an initial steep decline in HCV RNA during the first weeks of treatment (immediate virologic response), is followed by a phase of less steep decline.

Regulation (response) of interferon-alpha associated with chronic hepatitis and hepatitis c virus infection

18) Confidence 0.12 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676642 Disease Relevance 0.82 Pain Relevance 0.04

Grade 3 and 4 myalgias affected 5% of patients on pegIFNa-2b, compared with 17% of patients on HDI.

Regulation (affected) of pegIFNa-2b

19) Confidence 0.11 Published 2010 Journal Core Evidence Section Body Doc Link PMC2963921 Disease Relevance 0.69 Pain Relevance 0.11

Modulation of alpha-interferon's antiviral and clinical effects by aspirin, acetaminophen, and prednisone in healthy volunteers.

Regulation (Modulation) of alpha-interferon associated with aspirin and paracetamol

20) Confidence 0.10 Published 1995 Journal Antiviral Res. Section Title Doc Link 8585766 Disease Relevance 0.16 Pain Relevance 0.52

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