INT5298

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 70
Total Number 70
Disease Relevance 27.07
Pain Relevance 28.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTHFS) Golgi apparatus (MTHFS) plasma membrane (MTHFS)
ligase activity (MTHFS) cytoplasm (MTHFS)
Anatomy Link Frequency
platelet 8
leukocytes 2
PMNs 2
outflow 1
saphenous vein 1
MTHFS (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 436 99.98 Very High Very High Very High
aspirin 158 99.92 Very High Very High Very High
Potency 9 99.92 Very High Very High Very High
Inflammation 192 99.86 Very High Very High Very High
tramadol 8 99.76 Very High Very High Very High
analgesia 6 99.72 Very High Very High Very High
Analgesic 46 99.68 Very High Very High Very High
rheumatoid arthritis 35 99.60 Very High Very High Very High
Paracetamol 35 99.60 Very High Very High Very High
Central nervous system 4 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 299 99.86 Very High Very High Very High
Rheumatoid Arthritis 35 99.60 Very High Very High Very High
Pseudotumor Cerebri 1 98.92 Very High Very High Very High
Renal Failure 3 98.80 Very High Very High Very High
Disease 51 98.74 Very High Very High Very High
Osteoarthritis 77 98.72 Very High Very High Very High
Colon Cancer 15 98.68 Very High Very High Very High
Diabetes Mellitus 14 98.52 Very High Very High Very High
Renal Disease 2 98.28 Very High Very High Very High
Adhesions 4 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present investigation we have evaluated the effect of salicylate and acetaminophen on aspirin induced inhibition of cyclo-oxygenase and platelet function.
Negative_regulation (inhibition) of cyclo-oxygenase in platelet associated with aspirin and paracetamol
1) Confidence 0.57 Published 1982 Journal Prostaglandins Leukot Med Section Abstract Doc Link 6813873 Disease Relevance 0 Pain Relevance 0.47
Salicylate at concentrations above 5 mM effectively blocked the inhibition of cyclo-oxygenase activity and platelet aggregation in response to arachidonate.
Negative_regulation (inhibition) of cyclo-oxygenase in platelet
2) Confidence 0.57 Published 1982 Journal Prostaglandins Leukot Med Section Abstract Doc Link 6813873 Disease Relevance 0 Pain Relevance 0.46
The increased intestinal permeability was proportional to drug potency to inhibit cyclo-oxygenase.
Negative_regulation (inhibit) of cyclo-oxygenase associated with potency
3) Confidence 0.57 Published 1986 Journal Drugs Section Abstract Doc Link 3780475 Disease Relevance 0.47 Pain Relevance 0.87
The urinary concentrations of 6-MNA are very low and its urinary metabolites are weak inhibitors of cyclo-oxygenase.
Negative_regulation (inhibitors) of cyclo-oxygenase
4) Confidence 0.57 Published 1993 Journal Pharmacol. Res. Section Abstract Doc Link 8108313 Disease Relevance 0.44 Pain Relevance 0.26
The primary mode of action of these drugs as antipyretics appears at present to be the inhibition of cyclo-oxygenase and a consequent reduction of prostanoid material in pyrogen-sensitive areas of the brain.
Negative_regulation (inhibition) of cyclo-oxygenase in brain
5) Confidence 0.57 Published 1985 Journal Prog. Neurobiol. Section Abstract Doc Link 3911273 Disease Relevance 0.94 Pain Relevance 0.37
As leukotriene C4 is a potent gastric vasoconstrictor, increased metabolism of arachidonic acid via the 5-lipoxygenase pathway in the presence of inhibition of cyclo-oxygenase could possibly contribute to drug-induced gastrointestinal damage.
Negative_regulation (inhibition) of cyclo-oxygenase
6) Confidence 0.57 Published 1986 Journal Med Toxicol Section Abstract Doc Link 3547000 Disease Relevance 0.32 Pain Relevance 0.48
We suggest that, as soon as the disease has been diagnosed, patients should be treated with a disease-modifying drug and, if necessary, an analgesic which does not inhibit cyclo-oxygenase.
Negative_regulation (inhibit) of cyclo-oxygenase associated with analgesic and disease
7) Confidence 0.57 Published 1986 Journal Agents Actions Section Abstract Doc Link 3099559 Disease Relevance 0.76 Pain Relevance 0.46
All of these show more or less marked antiinflammatory activities, which for some of them are the result of an inhibition of cyclo-oxygenase and of prostaglandin biosynthesis, in which case they should be more properly classified as mild NSAIDs.
Negative_regulation (inhibition) of cyclo-oxygenase associated with inflammation and cinod
8) Confidence 0.57 Published 1992 Journal Int J Tissue React Section Abstract Doc Link 1300311 Disease Relevance 0.59 Pain Relevance 0.48
It is suggested that the phenylacetic acid derivative non-steroidal anti-inflammatory drugs may have a composite action in vivo: by inhibition of cyclo-oxygenase they reduce prostaglandin production (and so produce some symptomatic relief in the same manner as the drugs in the other chemical groups of non-steroidal anti-inflammatory agents) and by suppression of lymphocyte replication they may interfere with the pathogenesis of certain chronic rheumatic diseases.
Negative_regulation (inhibition) of cyclo-oxygenase in lymphocyte associated with inflammation, cinod and rheumatic diseases
9) Confidence 0.57 Published 1988 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2460411 Disease Relevance 0.41 Pain Relevance 0.44
Doses of sulindac that spare basal renal cyclo-oxygenase do inhibit extrarenal cyclo-oxygenase.
Negative_regulation (inhibit) of cyclo-oxygenase
10) Confidence 0.53 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3092666 Disease Relevance 0.36 Pain Relevance 0.36
However, the functional consequences of renal cyclo-oxygenase inhibition are partially attenuated in patients with lupus nephritis vis-à-vis other forms of chronic glomerular disease because of concomitant suppression of enhanced glomerular thromboxane A2 production.
Negative_regulation (inhibition) of cyclo-oxygenase associated with renal disease and disease
11) Confidence 0.53 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3092667 Disease Relevance 0.76 Pain Relevance 0.30
Nonsteroidal anti-inflammatory drugs inhibit cyclo-oxygenase activity and thereby reduce prostaglandin synthesis.
Negative_regulation (inhibit) of cyclo-oxygenase associated with inflammation and cinod
12) Confidence 0.53 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3092666 Disease Relevance 0.24 Pain Relevance 0.24
When aspirin is administered in doses as low as 40-160 mg per day, it inhibits platelet cyclo-oxygenase activity by more than 80%.
Negative_regulation (inhibits) of cyclo-oxygenase in platelet associated with aspirin
13) Confidence 0.53 Published 1986 Journal N Engl Reg Allergy Proc Section Abstract Doc Link 3302653 Disease Relevance 0.07 Pain Relevance 0.35
The potential pharmacokinetic and pharmacodynamic interactions between zileuton, a 5-lipoxygenase inhibitor, and naproxen, a nonsteroidal anti-inflammatory drug that acts as a cyclo-oxygenase inhibitor, have been investigated in 24 healthy volunteers.
Negative_regulation (inhibitor) of cyclo-oxygenase associated with inflammation and cinod
14) Confidence 0.45 Published 1995 Journal Clin Pharmacokinet Section Abstract Doc Link 8620667 Disease Relevance 0.10 Pain Relevance 0.10
Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to induce analgesia mainly via the inhibition of cyclo-oxygenase.
Negative_regulation (inhibition) of cyclo-oxygenase associated with inflammation, cinod and analgesia
15) Confidence 0.44 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12208318 Disease Relevance 0.34 Pain Relevance 0.52
All NSAIDs are known inhibitors of cyclo-oxygenase, the enzyme responsible for converting arachidonic acid to prostaglandins.
Negative_regulation (inhibitors) of cyclo-oxygenase associated with cinod
16) Confidence 0.43 Published 1997 Journal Ann. Med. Section Abstract Doc Link 9240630 Disease Relevance 0.36 Pain Relevance 0.47
Prostaglandins have been implicated in the pathogenesis of colon cancer and it has been suggested that the preventive effect of NSAIDs is due to inhibition of cyclo-oxygenase activity.
Negative_regulation (inhibition) of cyclo-oxygenase in colon associated with colon cancer and cinod
17) Confidence 0.43 Published 1997 Journal Ann. Med. Section Abstract Doc Link 9240630 Disease Relevance 0.35 Pain Relevance 0.45
The assay sensitivity to detect renal cyclo-oxygenase inhibition was independently verified by measuring urinary 6-keto-PGF1 alpha in normal subjects before and after aspirin and ibuprofen, known inhibitors of renal prostaglandins.
Negative_regulation (inhibition) of cyclo-oxygenase associated with aspirin
18) Confidence 0.42 Published 1993 Journal Pharmacol. Res. Section Abstract Doc Link 8108313 Disease Relevance 0.51 Pain Relevance 0.26
Immunosuppressive actions of prostaglandins and the possible increase in chronic inflammation after cyclo-oxygenase inhibitors.
Negative_regulation (inhibitors) of cyclo-oxygenase associated with inflammation
19) Confidence 0.42 Published 1986 Journal Agents Actions Section Title Doc Link 3099559 Disease Relevance 0.63 Pain Relevance 0.47
At low concentrations they enhanced replicative growth, due to cyclo-oxygenase inhibition of cells from some subjects, but at higher concentration they suppressed replicative growth of cells from all subjects, with only a minor effect on activation at very high concentration.
Negative_regulation (inhibition) of cyclo-oxygenase
20) Confidence 0.42 Published 1988 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2460411 Disease Relevance 0.21 Pain Relevance 0.37

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