INT52980

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Context Info
Confidence 0.37
First Reported 1993
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 5.14
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dlat) transferase activity, transferring acyl groups (Dlat)
Anatomy Link Frequency
plasma 2
hippocampus 2
neuron 1
Uterine 1
Dlat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 296 100.00 Very High Very High Very High
Dopamine 39 99.64 Very High Very High Very High
Somatostatin 314 99.58 Very High Very High Very High
agonist 60 99.50 Very High Very High Very High
Osteoarthritis 4 98.72 Very High Very High Very High
Acupuncture 47 98.62 Very High Very High Very High
rheumatoid arthritis 2 97.96 Very High Very High Very High
Acute pain 1 97.64 Very High Very High Very High
Pyramidal cell 68 97.24 Very High Very High Very High
Hippocampus 55 95.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 121 100.00 Very High Very High Very High
Endometriosis (extended) 24 99.12 Very High Very High Very High
Osteoarthritis 5 98.72 Very High Very High Very High
Hot Flashes 1 98.68 Very High Very High Very High
Rheumatoid Arthritis 3 97.96 Very High Very High Very High
Pain 20 97.64 Very High Very High Very High
Benign Prostatic Hypertrophy 25 96.68 Very High Very High Very High
Cv Unclassified Under Development 168 95.40 Very High Very High Very High
Low Back Pain 21 94.60 High High
Endometrial Cancer 32 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The clinical relevance of piroxicam-beta-cyclodextrin (PBC) in the long-term treatment of osteoarthritis and rheumatoid arthritis is reviewed.
Positive_regulation (relevance) of PBC associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.37 Published 1993 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 7805704 Disease Relevance 0.58 Pain Relevance 0.38
When TP was 0.74 mg/kg, with the increase of the dosage of E2, the volume and quotient of prostate were increasing.
Positive_regulation (increase) of E2
2) Confidence 0.29 Published 2010 Journal Indian Journal of Pharmacology Section Abstract Doc Link PMC2959216 Disease Relevance 0.29 Pain Relevance 0.09
BACKGROUND: The clinical effects of piroxicam-beta-cyclodextrin (PBC) in sachet form have been surveyed in patients with osteoarthritic or acute pain in western countries, but scarcely studied in those with chronic low back pain (LBP), and never investigated in the field of postural sway.
Spec (investigated) Positive_regulation (effects) of PBC associated with low back pain, chronic low back pain, acute pain and osteoarthritis
3) Confidence 0.28 Published 2008 Journal J Clin Pharm Ther Section Abstract Doc Link 18834364 Disease Relevance 0.37 Pain Relevance 0.34
Presently, we found that G1 also mimics E2-dependent increases in fEPSPs, which corroborates the hypothesis that GPR30 is present and functional in pyramidal neurons of the rat hippocampus and that this receptor may mediate some of the short latency actions of E2 on neuronal excitability.
Positive_regulation (increases) of E2 in hippocampus associated with neuronal excitability, pyramidal cell and hippocampus
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.13 Pain Relevance 0.35
Therefore, we evaluated the potential neuroprotective action of the natural estrogen E2 and two synthetic estrogenic compounds that do not bind ER-?
Positive_regulation (evaluated) of E2
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.60 Pain Relevance 0.32
The GPR30 agonist G1 mimics short latency E2 potentiation of hippocampal CA1 neuron excitability
Positive_regulation (potentiation) of E2 in neuron associated with agonist
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.14 Pain Relevance 0.29
In addition, it is reported that in the cycling female rat hypothalamic SOM content and SOM release from the ME fluctuate concurrently with plasma E2 levels during the estrous cycle (Estupina et al. 1996; Freeman 1994; Knuth et al. 1983; Zorilla et al. 1991).
Positive_regulation (fluctuate) of E2 in plasma associated with somatostatin
7) Confidence 0.18 Published 2008 Journal Exp Brain Res Section Body Doc Link PMC2441535 Disease Relevance 0 Pain Relevance 0.47
RESULTS: After modeling, the writhing latency shortened considerably and the writhing times, serum FSH, LH and E2 levels increased apparently, and serum P content decreased markedly (P<0.05).
Positive_regulation (increased) of E2
8) Confidence 0.18 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0.05 Pain Relevance 0
Yet, SOM release from the ME was found to be maximal on the day of proestrus (Estupina et al. 1996), concurrent with cyclic elevations of plasma E2 and P levels (Freeman 1994).
Positive_regulation (elevations) of E2 in plasma associated with somatostatin
9) Confidence 0.15 Published 2008 Journal Exp Brain Res Section Body Doc Link PMC2441535 Disease Relevance 0 Pain Relevance 0.52
In addition, the total flavonoid fraction of HEP can improve bone mineral density, enhance the E2 level and decrease the circulating IL-6 level in OVX rats (13).
Positive_regulation (enhance) of E2
10) Confidence 0.13 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.24 Pain Relevance 0
positive cells in the No E2/saline group trended (showed a trend to be) higher than in the No E2/CFA group, suggesting the CFA induced a decrease in ER?
Positive_regulation (trended) of E2
11) Confidence 0.10 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2811708 Disease Relevance 0.59 Pain Relevance 0.41
Furthermore, E2-induces ERK activation in the CA1 region after GCI, which is critical for its neuroprotective effects as treatment with a MEK inhibitor blocked E2-induced ERK activation and E2 neuroprotection in the hippocampus [27] Likewise, a role for the prosurvival serine kinase Akt in E2 neuroprotection has been implicated, as E2 rapidly up-regulates Akt activation in cortical neurons in vitro [28], and in the hippocampus CA1 in vivo following GCI [29], while treatment with a PI3K inhibitor attenuates the neuroprotective effects of E2 both in vitro and in vivo [28], [29].
Positive_regulation (activation) of E2 in hippocampus associated with ischemia and hippocampus
12) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.53 Pain Relevance 0.38
It is possible that the E2 induced increase in GH receptor mRNA is transient, or E2 has different effects in mice and rats.
Positive_regulation (induced) of E2
13) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
Recently, in a randomized controlled trial, AC and auricular treatment significantly decreased the FSH level while increased the E2 level to relieve the menopausal hot flashes of the bilaterally ovariectomized women [37].
Positive_regulation (increased) of E2 associated with hot flashes, endometriosis (extended) and acupuncture
14) Confidence 0.07 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2957198 Disease Relevance 0.28 Pain Relevance 0.19
Uterine ER mRNA and IGF-I mRNA levels were not affected by short time (24 hrs) GH treatment in ovariectomized rats, while E2 in the same regimen caused increased mRNA levels in both cases [11].
Positive_regulation (increased) of E2 in Uterine
15) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.14 Pain Relevance 0
mRNA level was increased in the E2 treated rats compared with OVX controls (Fig. 2).
Positive_regulation (increased) of E2
16) Confidence 0.06 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
In contrast, the intensity of PRL staining and the PRL-positive area was increased in the E2+G6-31 group compared to the E2 group (Fig. 5C).
Positive_regulation (increased) of E2
17) Confidence 0.06 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.21 Pain Relevance 0
The IGF-I mRNA level was highest in the TAM treated rats, but the levels in both E2 and TAM treated groups were increased as compared to OVX controls.
Positive_regulation (increased) of E2
18) Confidence 0.06 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.17 Pain Relevance 0
Our data suggest that one mechanism that may mediate E2-induced DA uptake inhibition is trafficking of DAT to an Ab-inaccessible site inside the cell.
Positive_regulation (mediate) of E2 associated with dopamine
19) Confidence 0.05 Published 2006 Journal J Mol Signal Section Body Doc Link PMC1769494 Disease Relevance 0.30 Pain Relevance 0.05
EDC and E2-BSA neuroprotective effects against GCI are mediated by ERK and Akt signaling pathways
Positive_regulation (mediated) of E2 associated with ischemia
20) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.38 Pain Relevance 0.15

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